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Vitamin Disorders

  • Chapter
Neuropsychiatric Features of Medical Disorders

Part of the book series: Critical Issues in Psychiatry ((CIPS))

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Abstract

Vitamin A (retinol) is a fat-soluble vitamin necessary in the body for epithelial integrity, formation of photoreceptor pigments in the retina, and stability of lysosomes. Foods plentiful in vitamin A include fish liver oil, eggs, butter, and green leafy and yellow vegetables. The minimum daily adult requirement for vitamin A is 5000 IU, while the usual therapeutic dose is 25,000–50,000 IU/day. Toxicity from ingestion of excessive amounts of vitamin A can be either acute or chronic.

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References

  • Adams PW, Wynn V, Seed M et al: Vitamin B6, depression, and oral contraception. Lancet 2: 516–517, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Anonymous: Folic acid and the nervous system. Lancet 2: 836, 1976.

    Google Scholar 

  • Anonymous: Wernicke’s preventable encephalopathy. Lancet 1: 1122–1123, 1979.

    Google Scholar 

  • Baumblatt MJ, Winston F: Pyridoxine and the pill. Lancet 1: 832–833, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Botez MI: Folate deficiency and neurological disorders in adults. Med Hypotheses 2: 135–140, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Botez MI, Cadotte M, Beaulieu R, et al: Neurologic disorders responsive to folic acid therapy. Can Med Assoc J 115: 217–222, 1976.

    PubMed  CAS  Google Scholar 

  • Brown RR, Rose DP, Leklem JE, et al: Effects of oral contraceptives on tryptophan metabolism and vitamin B6 requirements in women. Acta Vitaminol Enzymol 29: 151–157, 1975.

    PubMed  CAS  Google Scholar 

  • Brozek J: Psychological effects of thiamine restriction and deprivation in normal young men. Am J Clin Nutr 5: 109–120, 1957.

    PubMed  CAS  Google Scholar 

  • Bunn HF, Lee GR, Wintrobe MM: Pernicious anemia and other megaloblastic anemias, in Thorn GW, Adams RD, Braunwalde, et al (eds): Harrison’s Principles of Internal Medicine, ed 8. New York, McGraw—Hill, 1977, pp 1656–1664.

    Google Scholar 

  • Carney MWP, Sheffield BF: Associations of subnormal serum folate and vitamin B12 values and effects of replacement therapy. J Nery Ment Dis 150: 404–412, 1970.

    Article  CAS  Google Scholar 

  • Cooper BA, Whitehead VM: Evidence that some patients with pernicious anemia are not recognized by radiodilution assay for cobalamin. N Eng J Med 299: 816–818, 1978.

    Article  CAS  Google Scholar 

  • Cutforth RH: Adult scurvy. Lancet 1: 454–456, 1958.

    Article  PubMed  CAS  Google Scholar 

  • DiBenedetto RJ: Chronic hypervitaminosis A in an adult. JAMA 201: 700–702, 1967.

    Article  CAS  Google Scholar 

  • Driskell JA, Geders JM, Urban MC: Vitamin B6 status of young men, women, and women using oral contraceptives J Lab Clin Med 87: 813–821, 1976.

    PubMed  CAS  Google Scholar 

  • Donaldson RM: “Serum B12” and the diagnosis of cobalamin deficiency. N Engl J Med 299:827–828, 1978.

    Google Scholar 

  • Farmer CJ: Some aspects of vitamin C metabolism. Fed Proc 3: 179–188, 1944.

    CAS  Google Scholar 

  • Feldman MH, Schlezinger NS: Benign intracranial hypertension associated with hypervitaminosis A. Arch Neurol 22: 1–7, 1970.

    Article  CAS  Google Scholar 

  • Follis RH, Van Itallie TB: Pellagra, in Wintrobe MM, Thorn GW, Adams RD, et al (eds): Harrison’s Principles of Internal Medicine,ed 7. New York, McGraw—Hill, 1974a, pp 427–430.

    Google Scholar 

  • Follis RH, Van Itallie TB: Scurvy, in Wintrobe MM, Thorn GW, Adams RD, et al (eds): Harrison’s Principles of Internal Medicine, ed 7. New York, McGraw—Hill, 1974b, pp 434–436.

    Google Scholar 

  • Freeman JM, Finkelstein JD, Mudd SH: Folate-responsive homocystinuria and “schizophrenia.” N Eng J Med 292: 491–496, 1975.

    Article  CAS  Google Scholar 

  • Frostig JP, Spies TD: The initial nervous syndrome of pellagra and associated deficiency diseases. Am J Med Sci 199: 268–274, 1940.

    Article  Google Scholar 

  • Geagea K, Ananth J: Response of a psychiatric patient to vitamin B12 therapy. Dis Nerv Syst 36: 343–344, 1975.

    PubMed  CAS  Google Scholar 

  • Hällström T: Serum B12 and folate concentrations in mental patients. Acta Psychiatr Scand 45: 19–35, 1969.

    Article  PubMed  Google Scholar 

  • Hart RJ, McCurdy PR: Psychosis in vitamin B12 deficiency. Arch Intern Med 128: 596–597, 1971.

    Article  PubMed  Google Scholar 

  • Herbert V: Experimental nutritional folate deficiency in man. Trans Assoc Physicians 75: 307–320, 1962.

    CAS  Google Scholar 

  • Hodges RE, Hood J, Canham JE: Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr 24: 432–443, 1971.

    PubMed  CAS  Google Scholar 

  • Holmes JM: Cerebral manifestations of vitamin-B12 deficiency. Br Med J 4: 1394–1398, 1956.

    Article  Google Scholar 

  • Hunter R, Barnes J, Oakeley HF, et al: Toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet 1: 61–63, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Jefferson JW: The case of the numb testicles. Dis New Syst 38: 749–751, 1977.

    CAS  Google Scholar 

  • Kinsman RA, Hood J: Some behavioral effects of ascorbic acid deficiency. Am J Clin Nutr 24: 455–464, 1971.

    PubMed  CAS  Google Scholar 

  • Kolhouse JF, Kondo H, Allen NC, et al: Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin. N Eng J Med 299: 785–792, 1978.

    Article  CAS  Google Scholar 

  • Le Boeuf A, Lodge J, Eames PG: Vasopressin and memory in Korsakoff syndrome. Lancet 2: 1370, 1978.

    Google Scholar 

  • Lipton MA, Kane FJ: The use of vitamins as therapeutic agents in psychiatry, in Shader RI (ed): Psychiatric Complications of Medical Drugs. New York, Raven Press, 1972, pp 333–368.

    Google Scholar 

  • Malek-Ahmadi P, Behrmann PJ: Depressive syndrome induced by oral contraceptives. Dis New Syst 37: 406–408, 1976.

    CAS  Google Scholar 

  • Mesulam M-M, Van Hoesen GW, Butters N: Clinical manifestations of chronic thiamine deficiency in the rhesus monkey. Neurology 27: 239–245, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Mikkelsen B, Ehlers N, Thomsen HG: Vitamin A intoxication causing papilledema and simulating acute encephalitis. Acta Neurol Scand 50: 642–650, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Muenter MD, Perry HO, Ludwig J: Chronic vitamin A intoxication in adults. Am J Med 50: 129–136, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Nobbs BT: Pyridoxal phosphate status in clinical depression. Lancet 1: 405–406, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds EH: The neurology of vitamin B12 deficiency. Lancet 2: 832–833, 1976a.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds EH: Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 5: 661–696, 1976b.

    PubMed  CAS  Google Scholar 

  • Roos D: Neurological complications in patients with impaired vitamin B12 absorption following partial gastrectomy. Acta Neurol Scand 59 (suppl 69): 1–7, 1978.

    Google Scholar 

  • Roos D, Willanger R: Various degrees of dementia in a selected group of gastrectomized patients with low serum B12. Acta Neurol Scand 55: 363–376, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Rose DP, Strong R, Adams PW, et al: Experimental vitamin B6 deficiency and the effect of oestrogen-containing oral contraceptives on tryptophan metabolism and vitamin B6 requirements. Clin Sci 42: 465–477, 1972.

    PubMed  CAS  Google Scholar 

  • Rose M: Why assess vitamin-B12 status in patients with known neuropsychiatric disorder? Lancet 2: 1191, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Shafar J: Iatrogenic scurvy. Practitioner 194: 374–377, 1965.

    PubMed  CAS  Google Scholar 

  • Sheehan DV, Sheehan KH: Psychiatric aspects of oral contraceptive use. Psychiatr Ann 6: 501–509, 1976.

    Google Scholar 

  • Shulman R: Psychiatric aspects of pernicious anemia: A prospective controlled investigation. Br Med J 3: 266–270, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Shulman R: The present status of vitamin B12 and folic acid deficiency in psychiatric illness. Can Psychiatr J 17: 205–216, 1972.

    CAS  Google Scholar 

  • Spies TD, Aring CD, Gelperin J, et al:The mental symptoms of pellagra. Their relief with nicotinic acid. Am J Med Sci 196: 461–475, 1938.

    Article  Google Scholar 

  • Spillane JD: Nutritional Disorders of the Nervous System. Baltimore, Williams & Wilkins, 1947a, pp 12–15.

    Google Scholar 

  • Spillane JD: Nutritional Disorders of the Nervous System. Baltimore, Williams & Wilkins, 1947b, pp 29–47.

    Google Scholar 

  • Spivak JL, Jackson DL: Pellagra: An analysis of 18 patients and a review of the literature. Johns Hopkins Med J 140: 295–309, 1977.

    PubMed  CAS  Google Scholar 

  • Stokes J, Mendels J: Pyridoxine and premenstrual tension. Lancet 1: 1117–1178, 1972.

    Google Scholar 

  • Strachan RW, Henderson JG: Psychiatric syndromes due to a vitaminosis B12 with normal blood and marrow. Quart J Med 34: 303–317, 1965.

    PubMed  CAS  Google Scholar 

  • Sydenstricker VP: The history of pellagra, its recognition as a disorder of nutrition and its conquest. Am J Clin Nutr 6: 409–414, 1958.

    PubMed  CAS  Google Scholar 

  • Thornton WE, Thornton BP: Folic acid, mental function, and dietary habits. J Clin Psychiatry 39: 315–322, 1978.

    PubMed  CAS  Google Scholar 

  • Van Itallie TB: Thiamine deficiency, ariboflavinosis, and vitamin B6 deficiency, in Thorn GW, Adams RD, Braunwald E, et al(eds): Harrison’s Principles of Internal Medicine, ed 8. New York, McGraw—Hill, 1977, pp 455–459.

    Google Scholar 

  • Van Itallie TB, Follis RH: Thiamine deficiency, ariboflavinosis, and vitamin B6 deficiency, in Wintrobe MM, Thorn GW, Adams RD et al (eds): Harrison’s Principles of Internal Medicine, ed 7. New York, McGraw—Hill, 1974a, pp 430–432.

    Google Scholar 

  • Van Itallie TB, Follis RH: Defciencies of vitamins A, E, and K. Hypervitaminosis A, in Wintrobe MM, Thorn GW, Adams RD, et al (eds): Harrison’s Principles of Internal Medicine, ed 7. New York, McGraw—Hill, 1974b, pp 436–441.

    Google Scholar 

  • Victor M, Adams RD, Collins GH: The Wernicke—Korsakoff Syndrome. Philadelphia, FA Davis, 1971.

    Google Scholar 

  • Vollbracht R, Gilroy J: Vitamin A induced benign intracranial hypertension. Can J Neurol Sci 3: 59–61, 1976.

    PubMed  CAS  Google Scholar 

  • Walker A: Chronic scurvy. Br J Dermatol 80: 625–630, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Waxman S, Corcing JJ, Herbert V: Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization. Am J Med 48: 599–608, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Whitehead VM, Cooper BA: Failure of radiodilution assay for vitamin B12 to detect deficiency in some patients. Blood 50 (suppl 1): 99, 1977.

    Google Scholar 

  • Winston F: Oral contraceptives, pyridoxine, and depression. Am J Psychiatry 130: 1217–1221, 1973.

    PubMed  CAS  Google Scholar 

  • Wynn V: Vitamins and oral contraceptive use. Lancet 1: 561–564, 1975.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Wisconsin Medical School, Madison, Wisconsin, USA

    James W. Jefferson M.D. & John R. Marshall M.D.

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  1. James W. Jefferson M.D.
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  2. John R. Marshall M.D.
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© 1981 Plenum Publishing Corporation

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Jefferson, J.W., Marshall, J.R. (1981). Vitamin Disorders. In: Neuropsychiatric Features of Medical Disorders. Critical Issues in Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3920-5_11

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  • DOI: https://doi.org/10.1007/978-1-4684-3920-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3922-9

  • Online ISBN: 978-1-4684-3920-5

  • eBook Packages: Springer Book Archive

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