Abstract
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS). What impresses this reviewer much more, however, beyond the direct role MBP plays in the induction of an autoimmune experimental disease in certain strains of laboratory animals, is the fact that the major portion of the total MBP autoimmunology uncovered in recent years is clearly not involved in the induction of the autoimmune disease. To some the message given by this nonencephalitogenic portion possesses no greater meaning than didactic teachings from the realm of bovine serum albumin immunology; to others, this seemingly irrelevant “other” MBP immunology—an immunology against “self” that is not self-destructive—may be extremely vital. As an autoimmune process it may play a major role in the normal maintenance of protection against encephalomyelitis in most vertebrates either through direct participation or by indirect regulation. From this point of view the occasional emergence of EAE is seen as a defect in an otherwise protective immunology, a case in which horror autotoxicus is an exception to the rule.
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Day, E.D. (1981). Myelin Basic Protein. In: Inman, F.P., Mandy, W.J. (eds) Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3917-5_1
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