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Basic Biochemistry of Prostaglandin Metabolism with Especial Reference to PGDH

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The Prostaglandin System

Part of the book series: NATO Advanced Study Institutes Series ((ASIAS))

Abstract

The mammalian organism possesses extremely efficient mechamisms for the catabolism of PGs and hence their biological inactivation. The effeciency of certain vascular beds — for example, the lung — in inactivating PGs is well illustrated by the observations of Ferreira and Vane (18), who found that more than 95% of infused PGE2 was inactivated during one circulation through the lungs and by those of Hamberg and Samuelsson (26), who showed that only 3% of an intravenous bolus injection of tritiated PGE2 remained in the plasma after 90 s. After 4.5 min there was no detectable PGE2 at all.

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Authors and Affiliations

  1. Department of Prostaglandin Research, Wellcome Research Laboratories Langley Court, Beckenham, Kent, UK

    Roderick J. Flower

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  1. Roderick J. Flower
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Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti

  2. University of Padua, Verona, Italy

    G. P. Velo

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© 1981 Plenum Press, New York

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Flower, R.J. (1981). Basic Biochemistry of Prostaglandin Metabolism with Especial Reference to PGDH. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-3896-3_5

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