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Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the Ways in Which Some of these Affect the Longitudinal Muscle

  • Chapter
The Prostaglandin System

Part of the book series: NATO Advanced Study Institutes Series ((ASIAS))

Abstract

Prostaglandins (PGs) may have various roles in gastrointestinal function. They have also been implicated as contributors to various gastrointestinal diseases, including gastritis, gastric ulcer formation, ulcerative colitis, irritable bowel syndrome, idiopathic intestinal pseudo-obstruction, food intolerance, and radiation-induced and other forms of diarrhoea (1–8). In contrast, PGs administered as drugs may be useful in the treatment of peptic ulceration, prevention of aspirin- or indomethacin-induced gastric mucosal damage (9) and reversal of post-operative ileus (10). Knowledge of the types of compounds formed from the C20-unsaturated fatty acids eicosatrienoic, eicosatetraenoic (arachidonic) and eicosapentaenoic acids, and their actions on the human gut, is therefore important. Most studies to date have concerned PGE and PGFα compounds, but we have now extended this to include other metabolites of arachidonic acid.

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Author information

Authors and Affiliations

  1. Department of Surgery, King’s College Hospital Medical School, London, England

    Alan Bennet, Christopher N. Hensby, Gareth J. Sanger & Ian F. Stamford

  2. Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, England

    Alan Bennet, Christopher N. Hensby, Gareth J. Sanger & Ian F. Stamford

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  1. Alan Bennet
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  2. Christopher N. Hensby
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  3. Gareth J. Sanger
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  4. Ian F. Stamford
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti

  2. University of Padua, Verona, Italy

    G. P. Velo

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© 1981 Plenum Press, New York

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Bennet, A., Hensby, C.N., Sanger, G.J., Stamford, I.F. (1981). Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the Ways in Which Some of these Affect the Longitudinal Muscle. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_27

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  • DOI: https://doi.org/10.1007/978-1-4684-3896-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3898-7

  • Online ISBN: 978-1-4684-3896-3

  • eBook Packages: Springer Book Archive

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