Abstract
In the current literature, there are numerous reports of the biological activity of exogenously administered prostaglandins and variations in the endogenous production of prostaglandins under varie physiologic conditions. However, no method has been developed that clearly differentiates the in vivo actions of each biologically active product of arachidonic acid metabolism. Thus, the true physiologic and pathophysiologic significance of these compounds remains somewhat theoretical.
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References
A. Bennett, Prostaglandin antagonists, p.83, in: “Advances in Drug Research”, N. J. Harper and A. B. Simonds, eds., Academic Press, New York (1974).
A. Bennett and J. Posner, Studies on prostaglandin antagonists, Br. J. Pharmacol., 42: 584 (1971).
B. R. Beitch and K. E. Eakins, The effects of prostaglandins on the intraocular pressure of the rabbit, Br. J. Pharmacol., 37: 158 (1969).
J. F. Burka and P. Eyre, Studies of prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro, Prostaglandins, 6: 333 (1974).
N. Chand and P. Eyre, Effects of prostaglandin E1, E2 and F2a and polyphloretin phosphate on carotid blood pressure of domestic fowl, Arch. Int. Pharm. Ther., 221: 261 (1976).
W. E. Coyne and J. W. Cusic, Anticonvulsant semicarbazides, J. Med. Chem., 11: 1158 (1968).
W. W. Douglas, Histamine and antihistamines; 5-hydroxytryptamine and antagonists, p.621, in: “The Pharmacological Basis of Therapeutics”, L. S. Goodman and A. Gilman, eds., The Macmillan Company, New York (1970).
K. E. Eakins and J. H. Sanner, Prostaglandin antagonists, p.261„ in: “The Prostaglandins, Progress in Research”, S. M. M. Karim, ed., Medical and Technical Pub. Co. Ltd., London (1972).
J. D. Flack, Biological significance of the prostaglandins, p.174, in: “Recent Progress in Hormone Research”, P. W. Ramwell and J. E. Shaw, eds., Academic Press, New York (1970).
J. Fried, S. Heim, S. J. Etheredge, P. Sunder-Plassman, T. S. Santhanakrishan and J. Himizu, Synthesis of 15desoxy-7-oxaprostaglandin Fla and related substances, in: “Prostaglandin Symposium of the Worcester Foundation for Experimental Biology”, P. W. Ramwell and J. E. Shaw, eds., John Wiley and Sons, New York (1968).
J. Fried, T. S. Santhanakrishnan, J. Himizu, C. H. Lin, S. H. Ford, B. Rubin and E. 0. Grigas, Prostaglandin antagonists: synthesis and smooth muscle activity, Nature, 223: 208 (1969).
S. Hynie, J. Cepelik, M. Cernohorsky, V. Klenerova, J. Skrivanova and M. Wenke, 7-oxa-13 prostanoic acid and polyphloretin phosphate as non-specific antagonist of the stimulatory effects of different agents on adenylate cyclase from various tissues, Prostaglandins, 10: 971 (1975).
F. A. Keuhl and J. L. Humes, Direct evidence for a prostaglandin receptor and its application to prostaglandin measurement, Proc. Nat. Acad. Sci. U.S.A., 69: 480 (1972).
Y. T. Maddox, P. W. Ramwell, C. S. Shiner and E. J. Corey, Amide and 1-amino derivatives of F prostaglandins as prostaglandin antagonists, Nature, 273: 549 (1978).
A. A. Mathe, K. Strandberg and B. Fredholm, Antagonism of prostaglandin F2a induced bronchoconstriction and blood pressure changes by polyphloretin phosphate in the guinea pig and cat, J. Pharm. Pharmac., 24: 378 (1972).
J. Nakano, Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs, Br. J. Pharmacol., 44: 63 (1972).
J. Nakano,-A. V. Prancan and S. Moore, Effect of the prostaglandin antagonists in the vasoactivities of prostaglandin El (PGE1), E2 (PGE2), Al (PGA]) and F2a (PGF2a), Clin. Res., 19: 712 (1971).
M. Nickerson, Drugs inhibiting adrenergic nerves and structures innervated by them, p.549, in: “The Pharmacological Basis of Therapeutics”, L. S. Goodman and A. Gilman, eds., The Macmillan Company, New York (1970).
N. Ozaki, J. D. Kohli, L. I. Goldberg and J. Fried, Vascular smooth vuscle activity of 7-oxa-13-prostanoic acid, Blood Vessels, 16: 52 (1979).
M. K. Park and D. C. Dyer, Effect of polyphloretin phosphate and 7-oxa-13-prostanoic acid on vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries and 7-oxa-13-prostanoic acid on vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries, Prostaglandins, 3: 913 (1973).
J. H. Sanner, Antagonism of prostaglandin E2 by 1-acetyl-2(8-chloro-10,11-dihydrodibenz b,f 1,4 oxazepine-l0-carbonyl) hydrazine (SC-19220), Arch. Int. Pharmacodyn, Ther., 180:46(1969).
J. Sauner, Prostaglandin inhibition with a dibenzoxazepine hydrazide derivative and morphine, Ann. N.Y. Acad. Sci., 180: 396 (1971).
J. Sauner and K. E. Eakins, Prostaglandin antagonists, p.139, in: “Prostaglandins: Chemical and Biological Abnts S. M. M. Karim, ed., University Park Press, Baltimore (1976).
E. L. Tolman, R. Partridge and E. T. Barris, Prostaglandin E antagonists activity of 11,15-bisdeoxy prostaglandin El and congeners, Prostaglandins, 14: 11 (1977).
R. Villanueva, L. Hinds, R. L. Katz and K. E. Eakins, The effect of polyphloretin phosphate on some smooth muscle actions of prostaglandins in the cat, J. Pharm. and Exp. Ther., 180: 78 (1972).
T. C. Wicks, J. C. Rose, M. Johnson, P. W.Ramwell and P. A. Kot, Vascular responses to arachidonic acid in the perfused canine lung, Cir. Res., 38:167 (1976).
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© 1981 Plenum Press, New York
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Fitzpatrick, T.M., Stinger, R.B., Ramwell, P.W., Kot, P.A. (1981). Prostaglandin Analogs that Antagonize the Vascular Responses to Particular Prostaglandins. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_21
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DOI: https://doi.org/10.1007/978-1-4684-3896-3_21
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