Abstract
In 1970, three studies were published which provided the basis for the proposal that prostaglandins are modulators of pressor hormones and adrenergic nervous activity (1,2,3). In the first two studies, infusion of either angiotensin II or norepinephrine was shown to cause release of PGE-like material into renal venous blood; the latter was associated with attenuation of the vasoconstrictor and anti-diuretic actions of these pressor hormones (1,2). In the third study, it was demonstrated that within minutes after induction of unilateral renal ischemia, prostaglandins were released into the venous blood of both kidneys. Release from the contralateral kidney was mediated by angiotensin II, which, presumably, also contributed to the release from the ischemic kidney (3). This study offered an explanation for the antihypertensive function of the contralateral kidney in terms of a possible prostaglandin mechanism. Thus, activation of the reninangiotensin system by renal ischemia can effect enhanced prostaglandin production in the ischemic and contralateral kidneys. A related study on the effects of norepinephrine infusion and renal nerve stimulation on renal function (4) strongly supported the proposal that renal prostaglandins act as a component of an intrarenal negative feedback control system which moderates anti-diuretic and vasoconstrictor systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Reference
J. C. McGiff, K. Crowshaw, N. A. Terragno and A. J. Lonigro: . Nature, 227:1255–1257 (1970).
J. C. McGiff, K. Crowshaw, N. A. Terragno and A. J. Lonigro: Release of a Prostaglandin-Like Substance into Renal Venous Blood in Response to Angiotensin II. Circ. Res., 26 and 27 supp1. 1: 121–130 (1970).
J. C. McGiff, K. Crowshaw, N. A. Terragno, A. J. Lonigro, J. C. Strand, M. A. Williamson, J. B. Lee and K. K. F. Ng.: Prostaglandin-like Substances Appearing in Canine Renal Venous Blood During Renal Ischemia: Their Partial Characterization by Pharmacologic and Chromatographic Procedures. Circ. Res., 27: 765–782 (1970).
J. C. McGiff, K. Crowshaw, N. A. Terragno, K. U. Malik and A. J. Lonigro: Differential Effect of Noradrenaline and Renal Nerve Stimulation on Vascular Resistance in the Dog Kidney and the Release of a Prostaglandin E-like Substance. Clin. Sci., 42: 223–233 (1972).
E. W. Dunham and B. G. Zimmerman: Release of Prostaglandin-like Material from Dog Kidney during Renal Nerve Stimulation. Am. J. Physiol., 219: 1279–1299 (1970).
S. Moncada, R. J. Gryglewski, S. Bunting an J. R. Vane: An Enzyme Isolated from Arteries Transforms Prostaglandin Endoperoxides to an Unstable Substance that Inhibits Platelet Aggregation. Nature, 263: 663–666 (1976).
S. Moncada, R. Korbut, S. Bunting and J. R. Vane.: Prostacyclin is a Circulating Hormone. Nature, 273: 767–768 (1978).
J. C. McGiff, N. A. Terragno, J. C. Strand, J. B. Lee, A. J. Lonigro and K. K. F. Ng.: Selective Passage of Prostaglandin Across the Lung. Nature, 223: 742–745 (1969).
J. C. Frölich, B. J. Sweetman, K. Carr and J. A. Oates: Prostaglandin Synthesis in Rabbit Renal Medulla. Life Sci., 17: 1105–1112 (1975).
N. A. Terragno, D. A. Terragno: Prostaglandin Metabolism in the Fetal and Maternal Vasculature, Fed. Proc., 38: 75–77 (1979).
A. G. Herman, T. J. Verbeuren, S. Moncada, J. R. Vane and P. M. Vanhoutte: Effect of Prostacyclin on Myogenic Activity and Adrenergic Neuroeffector Interaction in Isolated Canine Veins. Arch. Int. Pharmacodyn. Ther., 232: 340–341 (1978).
A. E. Doyle and J. R. E. Fraser: Vascular Reactivity in Hypertension. Circ. Res., 9: 755–761 (1961).
N. A. Terragno, D. A. Terragno and J. C. McGiff: Contribution of Prostaglandins to the Renal Circulation in Conscious, Anesthetized and Laparotomized Dogs. Circ. Res., 40, 6: 590–595 (1977).
A. J. Lonigro, H. D. Itskovitz, K. Crowshaw, and J. C. McGiff: Dependency of Renal Blood Flow on Prostaglandin Synthesis in the Dog. Circ. Res., 32: 712–717 (1973).
J. Colina-Chourio, J. C. McGiff and A. Nasjletti: Effect of Indomethacin on Blood Pressure in the Normotensive Unanesthetized Rabbit: Possible Relation to Prostaglandin Synthesis Inhibition. Clin. Sci., 57: 359–365 (1979).
D. A. Terragno, K. Crowshaw, N. A. Terragno and J. C. McGiff: Prostaglandin Synthesis by Bovine Mesenteric Arteries and Veins. Circ. Res., 36 and 37, suppl. 1: 76–80 (1975).
S. Moncada, E. A. Higgs and J. R. Vane: Human Arterial and Venous Tissue Generate Prostacyclin (prostaglandin X), a Potent Inhibitor of Platelet aggregation. Lancet I: 18–20 (1977).
N. A. Terragno, J. C. McGiff and D. A. Terragno: Synthesis of Prostaglandins by Vascular and Nonvascular Renal Tissues and the Presence of an Endogenous Prostaglandin Synthesis Inhibitor in the Cortex. In: Advances in Pharmacology and Therapeutics, Vol. 4. Prostaglandins - Immunopharmacology, B. B. Vargaftig, ed., Pergamon Press, Oxford and New York (1979).
P. Y-K. Wong and J. C. McGiff: Detection of 15-hydroxyprostaglandin dehydrogenase in Bovine Mesenteric Blood Vessels. Biochim. Biophys. Acta., 500: 436–439 (1977).
P. Y-K. Wong, F. F. Sun and J. C. McGiff: Metabolism of Prostacyclin in Blood Vessels. J. Biol. Chem., 253, 16: 55–57 (1978).
C. P. Quilley, J. C. McGiff, W. H. Lee, F.F. Sun and P. Y-K. Wong: 6-keto PGE1, a Possible Metabolite of Prostacyclin: Cardiovascular and Platelet Anti-aggregatory Effects. Hypertension (In Press).
P. Y-K. Wong, J. C. McGiff, F. F. Sun and W. H. Lee: 6-keto Prostaglandin El Inhibits the Aggregation of Human Platelets. Eur. J. Pharmacol. (In Press).
C. P. Quilley, P. Y-K. Wong and J. C. McGiff: Hypotensive and Renovascular Actions of 6-keto Prostaglandin El, a Metabolite of Prostacyclin. Eur. J. Pharmacol., 57: 273–276 (1979).
K. U. Malik and J. C. McGiff: Modulation by Prostaglandin of Adrenergic Transmission in the Isolated Perfused Rabbit and Rat Kidney. Circ. Res., 36: 599–609 (1975).
P. G. Baer and J. C. McGiff: Comparison of Effects of Prostaglandins E2 and I2 on Rat Renal Vascular Resistance. Eur. J. Pharmacol., 54: 359–363 (1979).
P. B. Baer. M. L. Kauker and J. C. McGiff: Prostacyclin Effects on renal Hemodynamics and Excretory Functions in the Rat. J. Pharmacol. Exp. Therap., 208, 2: 294–297 (1979).
J. M. Armstrong, G.J. Blackwell, R. J. Flower, J.C. McGiff, K. M. Mullane and J. R. Vane: Genetic Hypertension in Rats is Accompanied by a Defect in Renal Prostaglandin Catabolism. Nature, 260, 552: 582–586 (1976).
P. Y-K. Wong, P. G. Baer and J. C. McGiff: Evidence for an Endogenous Inhibitor of 15-Hydroxyprostaglandin Dehydrogenase in New Zealand Genetically Hypertensive Rat Kidneys. Japanese Heart J., 20, suppl. 1: 186–188 (1979).
J. C. McGiff, N. A. Terragno, K. U. Malik and A. J. Lonigro: Release of a Prostaglandin E-like Substance from Canine Kidney by Bradykinin. Circ. Res., 31: 36–43 (1972).
J. C. McGiff and A. Nasjletti: Renal Prostaglandins and the Regulation of Blood Pressure. In: Prostaglandins and Cyclic AMP, Biologic Actions and Clinical Application, R. H. Kahn and W. E. M. Lands, eds., Academic Press Inc., New York and London (1973).
H. S. Margolius, R. Geller, W. de Jong, J. J. Pisano and A. Sjoerdsma: Urinary Kallikrein Excretion in Hypertension. Circ. Res., 31. suppl. 11: 125–131 (1972).
A.Nasjletti,J. C. McGiff and J. Colina-Chourio: Interrelations of the Renal Kallikrein-Kinin System and Renal Prostaglandins in the Conscious Rat. Circ. Res., 43, 5: 799–807 (1978).
J. C. McGiff and A. Nasjletti: Kinins, Renal Function and Blood Pressure Regulation. Fed. Proc., 35: 172–174 (1976).
A. Nasjletti, J. Colina-Chourio and J. C. McGiff: Disappearance of Bradykinin in the Renal Circulation of Dogs. Effects of Kininase Inhibition. Circ. Res., 37: 59–65 (1975).
J. C. McGiff, H. D. Itskovitz and N. A. Terragno: The Actions of Bradykinin and Eledoisin in the Canine Isolated Kidney; Relationship to Prostaglandins. Clin. Sci. Mol. Med., 49: 125–131 (1975).
M. A. Ondetti, B. Rubin and D. W. Cushman: Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents. Science, 196: 441–444 (1977).
J. M. Vinci, D. Horwitz, R. M. Zusman, J. J. Pisano, K. J. Catt and H. R. Keiser: The Effect of Converting Enzyme Inhibition with SQ 20, 881 on Plasma and Urinary Kinins, Prostaglandin E, and Angiotensin II in Hypertensive Man. Hypertension, 1: 416–426 (1979).
E. G. Erdös: The Kinins - A Status Report. Biochem. Pharmacol., 25: 1563–1569 (1976).
E. G. Spokas and H. H. Wang: Regional Blood Flow and Cardiac Responses to Hydralazine. J. Pharmacol. Exp. Therap. (In Press)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
McGiff, J.C., Spokas, E.G., Wong, P.YK. (1981). Prostaglandin Mechanisms in Blood Pressure Regulation and Hypertension. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3896-3_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3898-7
Online ISBN: 978-1-4684-3896-3
eBook Packages: Springer Book Archive