Abstract
Immune mechanisms fall into two major classes: firstly, reactions of humoral immunity involving the generation of antibodies by bone marrow derived thymus independent lymphocytes (B-lymphocytes); secondly, reactions of cellular immunity involving the generation of lymphokines, by thymus dependent lymphocytes (T-lymphocytes). Lymphokines are macromolecular agents, probably glycoprotein, which affect a range of cell types, including macrophages, neutrophils, lymphocytes, osteoclasts and vascular endothelium. Within this general framework there exists a range of cell/cell interactions to both specific antigens and nonspecific stimuli of lymphocyte function leading to the generation of antibodies or lymphokines. As well as mediator release in response to antigen stimulus T-lymphocytes are involved in the control of antibody secretion. Macrophages also play a role in the allergic response serving to regulate the secretion of lymphokines or antibodies. Neutrophils, eosinophils and basophils are more usually considered to be involved in immediate hypersensitivity anaphylactic type reactions though involvement in other responses may be more than incidental (e.g. basophils in Jones-Mote responses).
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References
C. B. Anderson, W. T. Newton and B. M. Jaffe. Transplantation, 19: 527 (1975).
M. A. Bray, D. Gordon and J. Morley. Agents and Actions, 6: 171 (1976).
M. A. Bray, D. Gordon and J. Morley. Prostaglandins and Med., 1: 183 (1978).
M. A. Bray and J. Morley. In: “Immunology in Medicine” E. Holborow and W. G. Reeves, eds., Academic Press, London, 265 (1977).
K. Brune, M. Glatt, H. Kalin and B. A. Peskar. Nature, 274: 261 (1978).
J. Calderon and E. R. Unanue. Nature, 253: 359 (1975).
J. F. Dayer, S. R. Goldring and S. M. Krane. In: “Proc. Mech. Localised Bone Loss”, J. E. Horton, T. M. Tarpley and W. F. Davis, eds., Inf. Res. Inc. U.S.A., 181 (1978).
M. DuComb, P. Polgar and C. Franzblau. Prostaglandins, 15: 708 (1978).
A. Farzad, A. S. Penneys, A. Ghaffar, V. A. Ziboh and J. Schlossberg. Prostaglandins, 14: 829 (1979).
E. J. Goetzl, J. A. Wood and R. R. Gorman. J. Clin.Invest., 59: 179 (1977).
J. S. Goodwin, A. D. Bankhurst, S. A. Murphy, D. S. Selinger, R. P. Messner and R. C. Williams. J. Clin. Lab. Immunol., 1: 197 (1978).
J. S. Goodwin, R. P. Messner, A. D. Bankhurst, G. T. Peake, J. H. Saiki and R. C. Williams. New Eng. J. Med., 297: 963 (1977).
T. J. Hubscher. J. Immunol., 114: 1389 (1975).
J. L. Humes, R. J. Bonney, L. Pelus, M. E. Dahlgren,S.J. Vsadowski, F. A. Keuhl and P. Davies. Nature, 269: 149 (1977).
J. L. Humes and H. R. Strausser. Prostaglandins, 5: 183 (1974).
J. P. Kelly, M. C. Johnson and C. W. Parker. J. Immunol., 122: 1563 (1979).
P. J. Kirby, J. Morley, J. R. Ponsford and W. I. McDonald. Prostaglandins, 11: 621 (1976).
T. Kishimoto and K. Ishizaka. J. Immunol., 116: 534 (1976).
E. A. Kitchen, J. R. Boot and W. Dawson. Prostaglandins, 16: 239 (1978).
F. A. Kuehl. Comprehensive Immunology, 3: 145 (1977).
J. I. Kurland, R. S. Bockman, H. E. Broxmeyer and M. A. Moore. Science, 199: 552 (1978).
L. M. Lichtenstein, E. Gillespie, H. R. Bourne and C. S. Henney. Prostaglandins, 2: 519 (1972).
L. M. Lichtenstein and S.Margolis. Science, 161: 902 (1968).
L. D. Loose and N. R. Di Luzio. J. Retic. Soc., 13: 70 (1973).
J. Mendelsohn, M. M. Multer and R. F. Boone. J. Clin. Invest., 52: 2129 (1973).
J. Mertin and D. Hughes. Int. Arch. Allergy Appl. Immunol., 48: 203 (1975).
J. Morley. Prostaglandins, 8: 315 (1974).
J. Morley. In: “Inflammation” (eds. J. R. Vane and S. H. Ferreira, Handbook of Exp. Pharm., 50/1. 314 (178).
J. Morley, M. A. Bray, R. W. Jones, D. H. Nugteren and D. A. Van Dorp. Prostaglandins, 17: 730 (1979).
L. Myatt, M. A. Bray, D. Gordon and J. Morley. Nature, 257: 227 (1975).
C. W. Parker, J. P. Kelly, S. F. Falkenheim and M. G. Huber. J. Exp. Med., 149: 1487 (1979).
C. W. Parker, W. F. Stenson, M. G. Huber and J. P. Kelly. J. Immunol., 122: 1572 (1979).
L. M. Pelus, H. E. Broxmeyer, J. I. Kurland and M. A. Moore. J. Exp. Med., 150: 277 (1979).
L. M. Pelus and H. R. Strausser. Life Sciences, 20: 903 (1977).
L. M. Pelus and H. R. Strausser. Int. J. Cancer, 18: in press.
J. Plescia, A. Smith and K. Grinwich. Proc. Nat. Acad. Sci. U.S.A., 72: 1848 (1975).
F. Quagliata, V. S. W. Lawrence and J. M. PhilipsQuagliata. Cell. Immunol., 6: 457 (1973).
I. Rivkin and E. L. Becker. Fed. Proc., 31: 657 (1972).
I. Rivkin, J. Rosenblatt and E. L. Becker. J. Immunol., 115: 1126 (1975).
J. W. Smith, A. L. Steiner and C. W. Parker. J. Clin. Invest., 50: 442 (1971).
G. D. Stockman and D. M. Mumford. Exp. Haematol., 2: 65 (1974).
K. F. Trofatter and C. A. Daniels. J. Immunol., 122: 1363 (1979).
F. H. Valone, M. Franklin and E. J. Goetzl. Clin. Res., 27: 476A (1979).
D. R. Webb and P. L. Osheroff. Proc. Nat. Acad. Sci. U.S.A., 73: 1300 (1976).
G. Weissmann,P. Dukor and R. B. Zurier. Nature (New Biol.), 231: 131 (1971).
G. Weissmann,R. B. Zurier and S. Hoffstein. Am. J. Pathol., 68: 539 (1972).
T. Yoneda and G. R. Mundy. J. Exp. Med., 150: 338 (1979).
M. Zimecki and D. R. Webb. J. Immunol., 117: 2158 (1976).
R. B. Zurier and F. Quagliata. Nature, 234: 304 (1971).
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© 1981 Plenum Press, New York
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Bray, M.A., Morley, J. (1981). Prostaglandins and Immunity. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_15
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DOI: https://doi.org/10.1007/978-1-4684-3896-3_15
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