Abstract
In this chapter I will discuss the effect of the anti-inflammatory steroids on the generation of prostaglandins and other arachidonate oxidation products.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. D. Baxter and G. M. Tomkins, Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells. Proc. Nat. Acad. Sci., USA, 68: 932–937 (1971).
G. J. Blackwell, W. G. Duncombe, R. J. Flower, M. F. Parsons and J. R. Vane, The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. Br. J. Pharmac., 59: 353–366 (1977).
G. J. Blackwell, R. J. Flower, F. P. Nijkamp and J. R. Vane, Phospholipase A2 activity of guinea pig isolated perfused lungs: stimulation and inhibition by anti-inflammatory steroids. Br. J. Pharmacol., 62: 79–89 (1978).
R. E. Butler and B. W. O’Malley, he biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus. Biochem. Pharmac., 25: 1–12 (1976).
L. Chan and B. W. O’Malley, Mechanism of action of the sex steroid hormones. New. Engl. J. Med., 294: 1372–1379 (1976).
S. H. Ferreira, S. Moncada and J. R. Vane, Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biol., 231: 237–239 (1971).
N. Floman and U. Zor, Mechanism of steroid action in ocular inflammation: Inhibition of prostaglandin production. Invest. Ophthalmol. Visual Sci., 16: 69–73 (1977).
R. J. Flower and G. J. Blackwell, The importance of phospholipase A2 in prostaglandin biosynthesis. Biochem. Pharmac., 25: 285–291 (1976).
R. J. Flower and G. J. Blackwell, Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature, 278: 456–459 (1979).
R. J. Flower, R. Gryglewski, K. Herbaczynska-Cedro and J. R. Vane, The effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature New Biol., 238: 104–106 (1972).
R. J. Gryglewski, B. Panczenko, R. Korbut, L. Grodzinska and A. Ocetkiewicz, Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea-pigs. Prostaglandins, 10: 343–355 (1975).
M. Ramberg and B. Samuelsson, Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea-pig lung. Biochem. biophys. Res. Commun., 16: 942–949 (1974).
B. Haye, S. Champion and C. Jacquemin, Control by TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid. FEBS Letters, 30: 253–260 (1973).
K. Herbaczynska-Cedro and J. Staszewska-Barczak, Adrenocortical hormones and the release of prostaglandin-like substances (PLS). Abstract of II Congress of Hungarian Pharmacological Society, p.19, Budapest (1974).
S-C.L. Hong and L. Levine, Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory steroids. Proc. Natn. Acad. Sci., USA., 73: 1730–1734 (1976).
F. Kantrowitz, D. C. Robinson, M. B. McGuire and L. Levine, Corticosteroids inhibit prostaglandin production by rheumatoid synovia. Nature, Lond., 258: 737–739 (1975).
H. Kunze and W. Vogt., Significance of phospholipase A for prostaglandins formation. Ann. N.Y. Acad. Sci., 180: 123–125 (1971).
G. P. Lewis and P. J. Piper, Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory steroids. Nature, Lond., 254: 308–311 (1975).
F. P. Nijkamp, R. J. Flower, S. Moncada and J. R. Vane, Partial purification of rabbit aorta contracting substance - releasing factor and inhibition of its activity by anti-inflammatory steroids. Nature, Lond., 263: 479–482 (1976).
L. Parente, G. Ammendola, P. Persico and M. Di Rosa, Glucocorticosteroids, prostaglandins and the inflammatory process. Pol. J. Pharmacol. Pharm., 30: 141–155 (1978).
B. Samuelsson, Biosynthesis of prostaglandins Fed. Proc., 31: 1442–1450 (1972).
J. B. Smith and A. L. Willis, Aspirin selectively inhibits prostaglandin production in human platelets. Nature, New Biol., 231: 235–237 (1971).
S. Tam,S-C. L. Hong and L. Levine, Relationships among the steroids of anti-inflammatory properties and inhibition of prostaglandin production and arachidonic acid release by transformed mouse fibroblasts. J. Pharmacol. Exp. Therap., 203: 162–168 (1977).
A. H. Tashjian, E. F. Voelkel, J. McDonough and L. Levine, Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature, Lond., 258: 739–741 (1975).
J. R. Vane, Inhibition of prostaglandin synthesis as mechanism of action for aspirin-like drugs. Nature, New Biol., 231: 232–235 (1971).
J. R. Vane and P. J. Piper, Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature (London), 233: 29–35 (1969).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Flower, R.J. (1981). Steroidal Anti-Inflammatory Drugs. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_13
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3896-3_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3898-7
Online ISBN: 978-1-4684-3896-3
eBook Packages: Springer Book Archive