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Serotonin Metabolism of Animal Model of Depression

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Book cover Serotonin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 133))

Abstract

Undoubtedly psychopathological research of mental patients is one indispensable, important method for clarifying the etiology of mental disorders, depression for example. However the fact that the object is a living person causes apparently methodological demerits or limitations. For example, a strictly controlled study which requires normal human controls or a study using various chemicals in the patients is extremely difficult. Direct analysis of pathological process in the brain of human patients is almost impossible. Even the observation and analysis of symptomatology can hardly obtain universally valid components because of the complex background factors involved. In this connection an animal model is strongly required in the etiological research of depression because it is expected that the problems mentioned above in the methodology could be avoided in an animal model study. By employing an animal model both a simplication of various factors like premorbid personality, social environments and interpersonal relationship and experiments requiring a number of controls and many kinds of operation become possible. Therefore several kinds of animal model of depression have been reported and used for research of depression. The Table 1 shows a series of animal models of depression published so far over the world.1–11 These are self-explanatory.

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Author information

Authors and Affiliations

  1. Department of Neuropsychiatry, Nagasaki University School of Medicine, Nagasaki 852, Japan

    R. Takahashi, T. Tateishi, H. Yoshida & H. Nagayama

  2. Neurochemistry Laboratories, Veterans Administration Hospital, Sepulveda, California, USA

    K. H. Tachiki

Authors
  1. R. Takahashi
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  2. T. Tateishi
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  3. H. Yoshida
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  4. H. Nagayama
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  5. K. H. Tachiki
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Editor information

Editors and Affiliations

  1. The University of Texas Medical Branch, Galveston, Texas, USA

    Bernard Haber

  2. Veterans Administration Medical Center, Brockton, Massachusetts, USA

    Sabit Gabay

  3. Brown University Division of Psychiatry and Human Behavior, Providence, Rhode Island, USA

    Sabit Gabay

  4. University of Athens School of Medicine, Athens, Greece

    M. R. Issidorides  & S. G. A. Alivisatos  & 

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© 1981 Plenum Press, New York

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Takahashi, R., Tateishi, T., Yoshida, H., Nagayama, H., Tachiki, K.H. (1981). Serotonin Metabolism of Animal Model of Depression. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_34

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  • DOI: https://doi.org/10.1007/978-1-4684-3860-4_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3862-8

  • Online ISBN: 978-1-4684-3860-4

  • eBook Packages: Springer Book Archive

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