Abstract
Circling behaviour applied to the study of dopaminergic mechanisms in the brain has been up to now a most fruitful pharmacological procedure and all its possibilities have certainly not been explored. It is however more and more evident that other neurotransmitters can also contribute to the expression of this behaviour. The recent demonstrations of the important role of GABA in the substantia nigra is one example (Scheel-Krüger et al. 1977; Waddington 1977; Oberlander et al. 1977) and the results obtained with novel series of piperidinyl indoles and tetrahydropyridinyl indoles (∆ 3,4) (Dumont et al. 1976; Nédelec et al. 1978), the general structure of which is shown in figure 1, is another. These compounds can be considered as semi-rigid serotonin analogues in which the side chain N atom is further away from the indole nucleus than it would be in the most stable conformations of serotonin itself (P. Hunt, L. Nédelec in preparation).
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References
Arnt, J., and Scheel-Kruger, J., 1979, GABAergic and glycinergic mechanisms within the substantia nigra pharmacological specificity of dopamine-independent contralateral turning behaviour and interactions with other neurotransmitters, Psychopharmacology, 62: 267.
Beck, D., and Shenker, K., 1968, Synthese von 2- und 3-(1,2,3, 6-Tetrahydropyridyl)-indolen, Heiv. Chim. Acta, 51: 260.
Boissier, J.R., Dumont, C., Oberlander, C., and Peterfalvi, M., 1976, A comparison of circling behaviour induced in nigrostriatal lesioned rats after peripheral administration of indole derivatives, Brit. J. Pharmacol. 58: 452 P.
Boissier, J.R., Oberlander, C., Dumont, C., and Peterfalvi, M., 1977, Pharmacological interactions with circling behaviour induced by the piperidinyl indole derivative RU 23686. Psychopharmacology, 55: 53.
Carter, C.J., and Pycock, C.J., 1977, Possible importance of 5hydroxytryptamine in neuroleptic-induced catalepsy in rats, Brit. J. Pharmacol, 60: 267 P.
Di Chiara, G., Morelli, M., Porceddu, M.L., and Gessa, G.L., 1978, Evidence that nigral gaba mediates behavioural responses elicited by striatal dopamine receptor stimulation, Life Sciences, 23: 2045.
Dray, A., Davies, J. Oakley, N.R., Tongroach, P., 1978, The Velucci, dorsal and medial raphe projection to the substantia nigra in the rat: electrophysiological, biochemical and behavioural observations, Brain Res., 151: 431.
Dumont, C., Guillaume, J. and Nédelec, L., 1976, Roussel-Uclaf Patent FR 2.362.628, (Chem. Abs., 89: 6229r, 1978 ).
Freter, K., 1975, Cycloalkenylindoles, J. Org. Chem., 40: 2525.
Friderichs, E., Bach, W. and Mutschler, E., 1975, Uber Serotonin derivate mit cyclisierter Seitenkette, 2 Mitt. Darstellung der isomeren 3-(Pyridyl) und 3-(Piperidyl)-5-Hydroxyindole, Archiv. der Pharmazie, 108: 663.
Grabowska, M., Antkiewicz, L., and Michaluk, J., 1974, A possible interaction of quipazine with central dopamine structures, J. Pharm. Pharmac., 26: 74.
Haigler, H.J., and Aghajanian, G.K., 1974, Peripheral serotonin antagonists: failure to antagonise serotonin in brain areas receiving a prominent serotoninergic input, J. neural transm., 35: 257.
Jacobs, B.L., and Klemfuss, H., 1975, Brain stem and spinal cord mediation of a serotoninergic behavioral syndrome, Brain Res., 100: 450.
Kannengiesser, M.H., Hunt, P., and Raynaud, J.P., 1973, An “in vitro” model for the study of psychotropic drugs and as a criterion of antidepressant activity, Biochem. Pharmacol., 22: 73.
Nédelec, L., Guillaume, J. and Dumont, C., 1978, Roussel-Uclaf Patents EP 3–199, 3–200.
Nelson, D.L., Herbet, A., Bourgoin, S., Glowinski, J. and Hauron, M., 1978, Characteristics of central 5-HT receptors and their adaptative changes following intracerebral 5,7 dihydroxytryptamine administration in the rat, Mol. Pharmacol., 14; 983.
Oberlander, C., Dumont, C., and Boissier, J.R., 1977, Rotational behaviour after unilateral intranigral injection of muscimol in rats, Eur. J. Pharmacol., 43: 389.
Pieri, L., Pieri, M., and Haefely, W., 1974, LSD as an agonist of dopamine receptors in the striatum, Nature, 252: 586.
Scheel-Kruger, J., Arnt, J., and Magelund, G., 1977, Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra, Neurosci. lett. 4: 351.
Trulson, M.E., Eubanks, E.E., and Jacobs, B.L., 1976, Behavioral evidence for supersensitivity following destruction of central serotoninergic nerve terminals by 5,7-dihydroxytryptamine, J. Pharmacol. Exptl. Therap., 198: 23.
Ungerstedt, U., 1971a, Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour, Acta Physiol. Scand. suppl. 367: 49.
Ungerstedt, U., 1971b, Postsynaptic supersensitivity after 6hydroxydopamine induced degeneration of the nigrostriatal dopamine system, Acta Physiol. Scand. suppl. 367: 69.
Waddington, J.L., 1977, GABA-like properties of flurazepam and baclofen suggested by rotational behaviour following unilateral intranigral injection: a comparison with the GABA-agonist muscimol, Brit. J. Pharmacol., 60: 263P.
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© 1981 Plenum Press, New York
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Hunt, P., Oberlander, C. (1981). The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Circling Behaviour. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_31
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DOI: https://doi.org/10.1007/978-1-4684-3860-4_31
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