Abstract
Extensive studies for the past 10 years on the control of serotonin (5-HT) synthesis in central serotoninergic neurons have led to the conclusion that most regulatory mechanisms involve the first step of the biosynthetic pathway, i.e. tryptophan hydroxylation. This reaction is catalyzed by a highly specific enzyme, tryptophan hydroxylase (L-tryptophan-5-monooxygenase, EC 1.14.16.4), which is not saturated by tryptophan under physiological conditions. Thence, fluctuations in the concentration of this precursor amino-acid in the vicinity of the enzyme as well as changes in the intrinsic activity of tryptophan hydroxylase can both produce significant alterations in the rate of 5-HT synthesis in the central nervous system (CNS) (see Hamon and Glowinski, 1974 for review).
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Hamon, M., Bourgoin, S., Artaud, F., Nelson, D. (1981). Regulatory Properties of Neuronal Tryptophan Hydroxylase. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_13
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DOI: https://doi.org/10.1007/978-1-4684-3860-4_13
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