Abstract
The isolated brain microvessels have been described as the morphological and functional correlate of the blood-brain barrier (9) and represent a separate and comparatively unique metabolic compartment (3, 5, 6). Previous investigations on the metabolism of brain capillaries have indicated that the brain microvasculature is more resistant to ischemia than the brain parenchyma (18). However, the metabolism of the microvessels does change during recirculation regardless of the intensity of the ischemic insult (5). Just as in the brain parenchyma, the pathophysiological events related to ischemia are evident in brain microvessels even after the blood circulation has been re-established (12). The severity of an ischemic insult is manifested primarily in the postischemic period (15). Recirculation appears to trigger its own set of events, including alterations in metabolite levels as well as in enzyme activities (5, 7, 19, 24). For example, some derangements in the levels of certain neurotransmitters of the brain were exhibited even after 7 days of recirculation following 15 minutes of bilateral ischemia in gerbils (2). In contrast, the enzymatic changes seem to be more pronounced in earlier stages of postischemia.
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References
Appel, S.H. and Parrot, B.L. (1970): Hexose monophosphate pathway in synapses. J. Neurochem. 17: 1619–1626.
Cvejid, V., Djuricid, B.M. and Mrsulja, B.B. (1980): Oscillatory pattern of catecholamine metabolism following transient cerebral ischemia in gerbils. This volume.
Djuricid, B.M. and Mrulja, B.B. (1977): Enzymic activity of the brain: Microvessels vs. total forebrain homogenate. Brain Res. 138: 561–564.
Djuricid, B.M. and Mrulja, B.B. (1979): Brain micro-vessel hexokinase: Kinetic properties. Experientia 35: 169–171.
DjuriciE, B.M. and Mrulja, B.B. (1979): Brain micro-vessels: Glucose metabolizing enzymes in ischemia and subsequent recovery. In: Pathophysiology of Cerebral Energy Metabolism, B.B. Mrsulja, Lj.M. Rakié, I. Klatzo and M. Spatz (eds.), pp. 239–252, Plenum Press, New York.
Djuricid, B.M., Rogac, Lj., Spatz, M., Raki, Lj, M. and Mrulja, B.B. (1978): Brain microvessels. I. Enzymic activities. Adv. neurol. Vol. 20, pp. 197–206, Raven Press, New York.
Djuricid, B.M., Simie, M. and Mrulja, B.B. (1979): Experimental brain ischemia and postischemia: Lactate dehydrogenase isoenzymes. Expt. neurol. (Submitted for publication).
Gaudet, R.J. and Levine, L. (1979): Transient cerebral ischemia and brain prostaglandins. Biochem. Biophys. Res. Comm. 86: 893–901.
Katzman, R. (1976): Workshop summary. In: Dynamics of Brain Edema, H.M. Pappius and W. Feindel (eds.), pp. 373–377, Springer, Berlin.
Kauffman, F.C. (1972): The quantitative histochemistry of the pentose phosphate pathway in the central nervous system of the rat. J. Neurochem. 19: 1–9.
Kauffman, F.C., Brown, J.G., Passonneau, J.V. and Lowry, O.H. (1969): Effects of changes in brain metabolism on levels of pentose phosphate pathway intermediates. J. biol. Chem. 244: 3647–3653.
Klatzo, I. (1979): Cerebral oedema and ischaemia. In: Recent Advances in Neuropathology, Vol. 1, W.T. Smith and J.B. Cavanagh (eds.), pp. 27–39, ChurchillLivingstone, Edinburgh, London and New York.
Lowry, O.H. and Passonneau, J.V. (1972): A flexible system 6f enzymatic analysis. Academic Press, New York.
Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randal, J.R. (1951): Protein measurement with the Folin phenol reagent. J. biol. Chem. 193: 265–275.
Mrsulja, B.B. (1979): Some new aspects of the pathochemistry of the postischemic period. In: Pathophysiology of Cerebral Energy Metabolism, B.B. Mrsulja, Lj. M. Rakib, I. Klatzo and M. Spatz (eds.), Plenum Press, New York.
Mrsulja, B.B. and Djuri6ió, B.M. (1979): Biochemical characteristics of cerebral capillaries. Symposium on the Cerebral Microvasculature, Galveston (In press).
Mrsulja, B.B., Djuricié, B.M., Cvejié, V., Mrsulja, B.J., Abe, K., Spatz, M. and Klatzo, I. (1980): Biochemistry of experimental ischemic brain edema. Proceedings of First International. Ernst Reuter Symposion on Brain Edema, Raven Press, New York (In press).
Mrsulja, B.B., Djuricié, B.M., Mrsulja, B.J., Rogac, Lj., Spatz, M. and Klatzo, I. (1978): Brain micro-vessels. II. Effects of ischemia and dihydroergotoxine in enzymic activities. Adv. neurol. Vol. 20, pp. 207–213, Raven Press, New York.
Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passonneau, J.V. and Klatzo, I. (1976): Postischemic changes in certain metabolites following prolonged ischemia in the gerbil cerebral cortex. J. Neurochem. 26: 1099–1103.
Mrsulja, B.B., Mrsulja, B.J., Cvejié, V., Djuricié, B.M. and Rogac, Lj. (1978): Alterations of putative neurotransmitters and enzymes during ischemia in gerbil cerebral cortex. J. Neural. Transm., Suppl. 14: 23–30.
Novello, F. and McLean, P. (1968): The pentose phosphate pathway of glucose metaboliim. Biochem. J. 107: 775–791.
Orlowski, M. (1976): Possible role of glutathione in transport processes. In: Adv. Expt. Med. Bioll., Vol. 69, pp. 13–28, Plenum Press, New York.
Razzel, W.E. and Kherana, H.G. (1959): Studies on polynucleotides. I. J. biol. Chem. 234: 2105–2113.
Schwartz, J.P., Mrulja, B.B., Mrsulja, B.J., Passonneau, J.V. and Klatzo, I. (1976): Alterations of cyclic nucleotide-related enzymes and of ATPase during unilateral ischemia and recirculation in gerbil cortex. J. Neurochem. 27: 101–107.
Sessa, G., Orlowski, M. and Green, J.P. (1976): Isolation from bovine brain of a fraction containing capillaries and a fraction containing membrane fragments of the choroid plexus. J. Neurobiol. 7: 51–61.
Spatz, M., MiEic, D., Fujimoto, T., Mrsulja, B.B. and Klatzo, I. (1979): Transport phenomena in cerebral ischemia. In: Pathophysiology of Cerebral Energy Metabolism, B.B. Mrsulja, Lj M., Raki E, I. Klatzo and M. Spatz (eds.), pp. 143–153, Plenum Press, New York.
Srivastava, L.M. and Hübscher, G. (1966): Glucose metabolism in the mucosa of small intestine. Enzymes of the pentose phosphate pathway. Biochem. J. 101: 48–55.
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Djuričić, B.M., Mršulja, B.B. (1980). Dynamics of Postischemia: Enzymes in Brain Capillaries. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_18
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DOI: https://doi.org/10.1007/978-1-4684-3836-9_18
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