Abstract
Brain capillaries and parenchyma are morphologically and metabolically separate and distinct compartments; the function of endothelial cells in transporting substances from blood to brain requires some specialized properties. The simplicity in isolating cerebral capillaries permits the investigation on their biochemical properties. Such an approach has revealed that the enzymatic organization of brain capillaries differs from that of the parenchyma (4–7, 11, 15). The brain capillaries which we have been studying are most probably a part of the blood-brain barrier (BBB); hence it is tentatively proposed that the specific biochemical organization of the brain microvasculature regulates the transport of substrates across the blood to the brain.
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Abe, T., Abe, K3, Swink, M.E., Klatzo, I. and Spatz, M. (1978): The H-norepinephrine uptake and fate in the isolated cerebral capillaries. Soc. Neuroscience, 8th Ann. Meet. (Abstracts), Vol. 4, p. 441.
Bertler, A., Falck, B., Owman, Ch. and Rosengren, E. (1966): The localization of monoaminergic blood-brain barrier mechanism. Pharmacol. Rev. 18: 369–385.
Christensen, H.N., Aspen, A.J. and Rice, E.G. (1956): Metabolism in the rat of three amino acids lacking alpha-hydrogen. J. Biol. Chem. 220: 287–294.
Djuricié, B.M. and Mrsulja, B.B. (1977): Enzymatic activity of the brain: microvessels vs. total brain homogenate. Brain Res. 138: 561–564.
Diuricié, B.M. and Mrsulja, B.B. (1979): Brain micro-vessel hexokinase: kinetic properties. Experientia 35: 169–171.
Diuricié, B.M., Rogac, Lj., Spatz, M., Rakié, Lj.M. and Mrsulja, B.B. (1978): Brain microvessels. I. Enzymic activities. In: Adv. Neurology, Vol. 20, J. Cervos-Navarro, et al. (eds.), pp. 197–205, Raven Press, New York.
Goldstein, G.W., Wolinsky, J.S., Csejtey, J. and Diamond, I. (1975): Isolation of metabolically active capillaries from rat brain. J. Neurochem. 25: 715–717.
Hardebo, J.E., Edvinson, L., Falck, B., Lindvall, M., Owmen, Ch., Rosengren, E. and Svengaard, N.A. (1976): Experimental models for histochemical and chemical studies of the enzymatic blood-brain harrier for amine precursors. In: The Cerebral Vessel Wall, J. Cervos-Navarro et al., (eds.), pp. 233–244, Raven Press, New York.
Kaplan, G.P., Hartman, B.K. and Creveling, C.R. (1979): Immunohistochemical demonstration of catechol-O-methyl transferase in mammalian brain. Brain Res. 167: 241–250.
Miéic, D.V., Swink, M., Midid, J., Klatzo, I. and Spatz, M. (1979): The ischemic and postischemic effects on the uptake of neutral amino acids in isolated cerebral capillaries. Experientia 35: 625–626.
Mrsulja, B.B. and Djuricie, B.M. (1979): Biochemical characteristics of cerebral capillaries. Symposium: The Cerebral Microvasculature, Galveston (in press).
Mrsulja, B.B., Mrsulja, B.J., Fujimoto, T., Klatzo, I. and Spatz, M. (1976): Isolation of brain capillaries: a simplified technique. Brain Res. 110: 361–365.
Orlowski, M. (1976): Possible role of glutathione in transport processes. In: Transport Phenomena in the Nervous System, G. Levy et al., (eds.) pp. 13–28, Plenum Press, New York.
Rapoport, S.I. (1976): Blood-Brain Barrier in Physiology and Medicine, Raven Press, New York.
Sessa, G., Orlowski, M. and Green, J.P. (1976): Isolation from bovine brain of a fraction containing capillaries and fraction containing membrane fragments of the choroid plexus. J. Neurobiol. 7: 51–61.
Spatz, M., Midid, D.V., Fujimoto, T., Mrsulja, B.B. and Klatzo, I. (1979): Transport phenomena in cerebral ischemia. In: Pathophysiology of Cerebral Energy Metabolism. B.B. Mrsulja, et al., (eds.) pp. 143–153, Plenum Press, New York.
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Mršulja, B.B., Djuričić, B.M., Micic, D.V. (1980). Metabolic Patterns in Cerebral Capillaries. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_16
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DOI: https://doi.org/10.1007/978-1-4684-3836-9_16
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