Skip to main content

Abstract

Brain capillaries and parenchyma are morphologically and metabolically separate and distinct compartments; the function of endothelial cells in transporting substances from blood to brain requires some specialized properties. The simplicity in isolating cerebral capillaries permits the investigation on their biochemical properties. Such an approach has revealed that the enzymatic organization of brain capillaries differs from that of the parenchyma (4–7, 11, 15). The brain capillaries which we have been studying are most probably a part of the blood-brain barrier (BBB); hence it is tentatively proposed that the specific biochemical organization of the brain microvasculature regulates the transport of substrates across the blood to the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abe, T., Abe, K3, Swink, M.E., Klatzo, I. and Spatz, M. (1978): The H-norepinephrine uptake and fate in the isolated cerebral capillaries. Soc. Neuroscience, 8th Ann. Meet. (Abstracts), Vol. 4, p. 441.

    Google Scholar 

  2. Bertler, A., Falck, B., Owman, Ch. and Rosengren, E. (1966): The localization of monoaminergic blood-brain barrier mechanism. Pharmacol. Rev. 18: 369–385.

    PubMed  CAS  Google Scholar 

  3. Christensen, H.N., Aspen, A.J. and Rice, E.G. (1956): Metabolism in the rat of three amino acids lacking alpha-hydrogen. J. Biol. Chem. 220: 287–294.

    PubMed  CAS  Google Scholar 

  4. Djuricié, B.M. and Mrsulja, B.B. (1977): Enzymatic activity of the brain: microvessels vs. total brain homogenate. Brain Res. 138: 561–564.

    Article  Google Scholar 

  5. Diuricié, B.M. and Mrsulja, B.B. (1979): Brain micro-vessel hexokinase: kinetic properties. Experientia 35: 169–171.

    Article  Google Scholar 

  6. Diuricié, B.M., Rogac, Lj., Spatz, M., Rakié, Lj.M. and Mrsulja, B.B. (1978): Brain microvessels. I. Enzymic activities. In: Adv. Neurology, Vol. 20, J. Cervos-Navarro, et al. (eds.), pp. 197–205, Raven Press, New York.

    Google Scholar 

  7. Goldstein, G.W., Wolinsky, J.S., Csejtey, J. and Diamond, I. (1975): Isolation of metabolically active capillaries from rat brain. J. Neurochem. 25: 715–717.

    Article  PubMed  CAS  Google Scholar 

  8. Hardebo, J.E., Edvinson, L., Falck, B., Lindvall, M., Owmen, Ch., Rosengren, E. and Svengaard, N.A. (1976): Experimental models for histochemical and chemical studies of the enzymatic blood-brain harrier for amine precursors. In: The Cerebral Vessel Wall, J. Cervos-Navarro et al., (eds.), pp. 233–244, Raven Press, New York.

    Google Scholar 

  9. Kaplan, G.P., Hartman, B.K. and Creveling, C.R. (1979): Immunohistochemical demonstration of catechol-O-methyl transferase in mammalian brain. Brain Res. 167: 241–250.

    Article  PubMed  CAS  Google Scholar 

  10. Miéic, D.V., Swink, M., Midid, J., Klatzo, I. and Spatz, M. (1979): The ischemic and postischemic effects on the uptake of neutral amino acids in isolated cerebral capillaries. Experientia 35: 625–626.

    Article  Google Scholar 

  11. Mrsulja, B.B. and Djuricie, B.M. (1979): Biochemical characteristics of cerebral capillaries. Symposium: The Cerebral Microvasculature, Galveston (in press).

    Google Scholar 

  12. Mrsulja, B.B., Mrsulja, B.J., Fujimoto, T., Klatzo, I. and Spatz, M. (1976): Isolation of brain capillaries: a simplified technique. Brain Res. 110: 361–365.

    Article  PubMed  CAS  Google Scholar 

  13. Orlowski, M. (1976): Possible role of glutathione in transport processes. In: Transport Phenomena in the Nervous System, G. Levy et al., (eds.) pp. 13–28, Plenum Press, New York.

    Google Scholar 

  14. Rapoport, S.I. (1976): Blood-Brain Barrier in Physiology and Medicine, Raven Press, New York.

    Google Scholar 

  15. Sessa, G., Orlowski, M. and Green, J.P. (1976): Isolation from bovine brain of a fraction containing capillaries and fraction containing membrane fragments of the choroid plexus. J. Neurobiol. 7: 51–61.

    Article  PubMed  CAS  Google Scholar 

  16. Spatz, M., Midid, D.V., Fujimoto, T., Mrsulja, B.B. and Klatzo, I. (1979): Transport phenomena in cerebral ischemia. In: Pathophysiology of Cerebral Energy Metabolism. B.B. Mrsulja, et al., (eds.) pp. 143–153, Plenum Press, New York.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Mršulja, B.B., Djuričić, B.M., Micic, D.V. (1980). Metabolic Patterns in Cerebral Capillaries. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3836-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3838-3

  • Online ISBN: 978-1-4684-3836-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics