Abstract
Platelet aggregation undoubtedly plays a major role in the pathogenesis of many types of ischemic cerebrovascular disease. When platelet aggregates occlude a vessel’s lumen, the vasoactive substances released from platelets, such as 5-hydroxytryptamine (serotonin), histamine and prostaglandin endoperoxide, may play a role in the genesis of the ischemic disease. Among these substances, prostaglandin endoperoxide and thromboxane A2 have recently drawn attention, because of their ability to contract the vessels and aggregate platelets. These prostaglandins (PGs) are produced from the arachidonic acid that probably originates from phospholipids in the platelet’s membrane.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Caen, J.P., Cronberg, S. and Kubisz, P. (1977): Physiology and Pathology, Stratton, p. 16, Intercontinental Medical Book Corp., New York.
Ellis, E.F., Nies, A.S. and Oates, J.A. (1977): Cerebral arterial smooth muscle contraction by thromboxane A2. Stroke 8: 480–483.
Ellis, E.F., Oels, O., Roberts, L.J., Payne, N.A., Sweetman, B.J., Nies, A.S. and Oates, J.A. (1976): Coronary arterial smooth muscle contraction by a substance released from platelets, evidence that it is thromboxane A2. Science 193: 1135–1137.
Furlow, T.W. and Bass, N.H. (1975): Fatty acids, platelets, and microcirculatory obstruction. Science 190: 491.
Furlow, T.W. and Bass, N.H. (1975): Stroke in rats produced by carotid injection of sodium arachidonate. Science 187: 658–660.
Furlow, T.W. and Bass, N.H. (1976): Arachidonateinduced cerebrovascular occlusion in the rat. Neurology 26: 297–304.
Hamberg, M., Svensson, J. and Samuelsson, B. (1975): Thromboxanes, a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA 72: 2994–2998.
Ramberg, M., Svensson, J., Wakabayashi, T. and Samuelsson, B. (1974): Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. Natl. Acad. Sci. USA 71: 345–349.
Haslam, R.J. (1964): Role of adenosine diphosphate in the aggregation of human blood platelets by thrombin and by fatty acids. Nature 202: 765–768.
Hovig, T. (1963): Release of a platelet aggregation substance (adenosine diphosphate) from rabbit blood induced by saline “extract” of tendon. Thrombi. Diath. Haemorrh. 9: 264–278.
Majno, G., Shea, S.M. and Leventhal, M. (1969): Endothelial constriction induced by histamine-type mediators. An electronmicroscopic study. J. Cell. Biol. 42: 647.
Motomiya, T., Matsubara, O. and Yamazaki, H. (in press): Constriction and damage of the pulmonary artery by suddenly induced intravascular aggregation of platelets. Cardiovascul. Surgery.
Mustard, J.F. and Packham, M.A. (1975): The role of blood and platelets in atherosclerosis and the complication of atherosclerosis. Thromb. Diath. Haemorrh. 33: 444–456.
Silver, M.J., Hoch, W. and Kocsis, J.J. (1974): Arachidonic acid causes sudden death in rabbits. Science 183: 1085–1087.
Smith, J.B. and Willis, A.L. (1970): Formation and release of prostaglandins by platelets in response to thrombin. Br. J. Pharmacol. 40: 545.
Spector, A.A. and Hoak, J.C. (1975): Fatty acids, platelets and microcircirculatory obstruction. Science 190: 490–491.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Fujimoto, T., Inaba, Y., Motomiya, T., Yamazaki, H. (1980). Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency. In: Spatz, M., Mršulja, B.B., Rakić, L.M., Lust, W.D. (eds) Circulatory and Developmental Aspects of Brain Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3836-9_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3836-9_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3838-3
Online ISBN: 978-1-4684-3836-9
eBook Packages: Springer Book Archive