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Comparative Approach to Mechanisms in the Maintenance of Early Pregnancy

  • Chapter
Reproductive Processes and Contraception

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

The sexually mature female pig (Sus scrofa, domestica) has recurring estrous cycles of 18–21 days that are not affected by season. The onset of behavioral estrus is characterized by elevated plasma levels of luteinizing hormone (LH surge) and elevated plasma estrogen (estradiol and estrone) concentrations that precede onset of estrus by 24–48 hr. Ovulation occurs 38–42 hr after onset of estrus, with gilts (virgin females) releasing 10–16 ova. Corpora lutea (CL) are well formed by day 4 or 5 of the estrous cycle, and plasma progesterone concentrations increase from about 5 ng/ml on day 4 to 30–40 ng/ml between days 12 and 14. Luteal regression begins on about day 15 in nonpregnant females, and plasma progesterone concentrations decline to basal levels (1 ng/ml or less) by day 17–18. This cycle repeats itself unless interrupted by pregnancy or events leading to endocrine dysfunction. These general comments concerning the porcine estrous cycle are based on data presented by Guthrie et al. (1972) and Anderson (1974).

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References

  • Allen, W.R., 1975, The influence of fetal genotype upon endometrial cup development and PMSG and progestagen production in equids, J. Reprod. Fertil. Suppl. 23:405.

    Google Scholar 

  • Allen, W.R., and Rowson, L.E., 1973, Control of the mare’s estrous cycle by prostaglandins, J. Reprod. Fertil. 33:359.

    Google Scholar 

  • Amoroso, E.C., 1952, Placentation, in: Marshall’s Physiology of Reproduction ( A.S. Parkes, ed.), pp. 127–311, Little, Brown, Boston.

    Google Scholar 

  • Anderson, L.L., 1974, Reproduction cycle in pigs, in: Reproduction in Farm Animals ( E.S.E. Hafez, ed.), pp. 275–287, Lea and Febiger, Philadelphia.

    Google Scholar 

  • Anderson, L.L., 1978, Growth, protein content and distribution of early pig embryos, Anat. Rec. 190: 143.

    Article  CAS  Google Scholar 

  • Anderson, L.L., and Bowerman, A.M., 1963, Utero-ovarian function of oxytocin-treated heifers, J. Anim. Sci. 22: 1136(abstract).

    Google Scholar 

  • Anderson, L.L., and Melampy, R.M. 1967, Hypophysial and uterine influences on pig luteal function, in: Reproduction in the Female Mammal (G.E. Lamming and E.C. Amoroso, eds.), pp. 285–316, Plenum Press, New York.

    Google Scholar 

  • Anderson, L.L., Butcher, R.L., and Melampy, R.M., 1961, Subtotal hysterectomy and ovarian function in gilts, Endocrinology 69: 571.

    Article  CAS  Google Scholar 

  • Anderson, L.L., Leglise, P.C., du Mesnil du Buisson, F., and Rombauts, P., 1965, Interaction des hormones gonadotropes et l’uterus dans le maintien du tissu luteal ovarien de la Truie, C. R . Acad. Sci. 261: 3675.

    CAS  Google Scholar 

  • Anderson, L.L., Bland, K.P., and Melampy, R.M., 1969, Comparative aspects of uterine—luteal relationships, Recent Prog. Horm. Res. 25: 27.

    Google Scholar 

  • Atkins, D.T., Sorenson, A.M., and Fleeger, J.L., 1974, 5a-Dihydroprogesterone in the pregnant mare, J. Anim. Sci. 39:196 (abstract).

    Google Scholar 

  • Barcikowski, B., Carlson, J.C., Wilson, L., and McCracken, J.M., 1974, The effect of endogenous and exogenous estradiol-l7ß on the release of prostaglandin F2 from the ovine uterus, Endocrinology 95: 1340.

    Article  CAS  Google Scholar 

  • Bartol, F.F., Kimball, F.A., Thatcher, W.W., Bazer, F.W., Chenault, J.R., Wilcox, C.J., and Kittok, R.J., 1977, Follicle, luteal and uterine parameters during the bovine estrous cycle, Proc. Am. Soc. Anim. Sci., p. 134, Madison, Wisconsin.

    Google Scholar 

  • Bazer, F.W., and Thatcher, W.W., 1977, Theory of maternal recognition of pregnancy in swine based on estrogen controlled endocrine versus exocrine secretion of prostaglandin F2« by the uterine endometrium, Prostaglandins 14: 397.

    CAS  Google Scholar 

  • Bazer, F.W., Roberts, R.M., and Sharp, D.C., 1978, Collection and analysis of female genital tract secretions, in: Methods in Mammalian Reproduction ( J.C. Daniels, Jr., ed.), pp. 503–528, Academic Press, New York.

    Google Scholar 

  • Bazer, F.W., Roberts, R.M., Basha, S.M.M., Zavy, M.T., Caton, D., and Barron, D.H., 1979, Method for obtaining ovine uterine secretions from unilaterally pregnant ewes, J. Anim. Sci. 49: 1522.

    CAS  Google Scholar 

  • Belt, W.D., Anderson, L.L., Cavazos, L.F., and Melampy, R.M., 1971, Cytoplasmic

    Google Scholar 

  • granules and relaxin levels in porcine corpora lutea, Endocrinology 89:10.

    Google Scholar 

  • Berg, S.L., and Ginther, O.J., 1978, Effect of estrogens on uterine tone and life span of the corpus luteum in mares, J. Anim . Sci. 47: 203.

    CAS  Google Scholar 

  • Bito, L.Z., 1972, Comparative study of concentrative prostaglandin accumulation by various tissues of mammals and marine vertebrates and invertebrates, Comp. Biochem. Physiol. 43A: 65.

    Article  CAS  Google Scholar 

  • Bito, L.Z., and Spellane, P.J., 1974, Saturable, “carrier-mediated,” absorption of prostaglandin Flo, from the in vivo rabbit vagina and its inhibition by prostaglandin F2B, Prostaglandins 8: 345.

    CAS  Google Scholar 

  • Bito, L.Z., Wallenstein, M., and Baroody, R., 1976, The role of transport processes in the distribution and disposition of prostaglandine, Adv. Prostaglandin Thromboxane Res. 1:297.

    Google Scholar 

  • Bolander, F.F., and Fellows, R.E., 1976, Purification and characterization of bovine placental lactogen, J. Biol. Chem. 251: 2703.

    CAS  Google Scholar 

  • Bolander, F.F., Ulberg, L.C., and Fellows, R.E., 1976, Circulating placental lactogen levels in dairy and beef cattle, Endocrinology 99: 1273.

    Article  CAS  Google Scholar 

  • Bowerman, A.M., Anderson, L.L., and Melampy, R.M., 1964, Urinary estrogens in cycling, pregnant, ovariectomized and hysterectomized gilts, Iowa State J. Sci. 38:437. Brunner, M.A., Donaldson, L.E., and Hansel, W., 1969, Exogenous hormones and luteal function in hysterectomized and intact heifers, J. Dairy Sci. 52: 1849.

    Google Scholar 

  • Burns, S.J., and Fleeger, J.L., 1975, Plasma progestogens in the pregnant mare in the first and last 90 days of gestation, J. Reprod. Fertil. Suppl. 23: 435.

    CAS  Google Scholar 

  • Buttle, H.L., and Forsyth, LA., 1976, Placental lactogen in the cow, J. Endocrinol. 68: 141.

    Article  CAS  Google Scholar 

  • Caldwell, B.V., Moor, R.M., Wilmut, 1., Polge, C., and Rowson, L.E.A., 1969, The relationship between day of formation and functional lifespan of induced corpora lutea in the pig, J. Reprod. Fertil. 18: 107.

    CAS  Google Scholar 

  • Carnegie, J.A., and Robertson, H.A., 1978, Conjugated and unconjugated estrogens in fetal and maternal fluids of the pregnant ewe: A possible role for estrone sulfate during early pregnancy, Biol. Reprod. 19: 202.

    Article  CAS  Google Scholar 

  • Carnegie, J.A., Chan, J.S.D., Robertson, H.A., Friesen, H.G., and McCully, M.E., 1977, Placental lactogen in the preattachment sheep embryo, Proc. Am. Soc. Anim. Sci., p. 142, Madison, Wisconsin.

    Google Scholar 

  • Casida, L.E., and Warwick, E.J., 1945, The necessity of the corpus luteum for maintenance of pregnancy in the ewe, J. Anim. Sci. 4: 34.

    Google Scholar 

  • Challis, J.R.G., 1971, A sharp increase in free circulating estrogens immediately before parturition in sheep, Nature (London) 229: 208.

    Article  CAS  Google Scholar 

  • Chen, T.T., Bazer, F.W., Gebhardt, B.M., and Roberts, R.M., 1975, Uterine secretion in mammals: Synthesis and placental transport of a purple acid phosphatase in pigs, Biol. Reprod. 13: 304.

    Article  CAS  Google Scholar 

  • Chenault, J.R., Thatcher, W.W., Kalra, Y.S., Abrams, R.M., and Wilcox, C.J., 1976, Plasma progestins, estradiol and luteinizing hormone following prostaglandin Fla injection, J. Dairy Sci. 59: 1342.

    Article  CAS  Google Scholar 

  • Choong, C.H., and Raeside, J.I., 1974, Chemical determination of estrogen distribution in the fetus and placenta of the domestic pig, Acta Endocrinol. 77; 171.

    CAS  Google Scholar 

  • Colcord, M.L., Hayer, G.L., and Weems, C.W., 1978, Effect of prostaglandin E2 (PGE2) as an antiluteolysin on estrogen-induced luteolysis in ewes, Proc. Am. Soc. Anim. Sci., p. 352, East Lansing, Michigan.

    Google Scholar 

  • Denamur, R., Martinet, J., and Short, R.V., 1970, Mode of action of estrogen in maintaining the functional life of the corpora lutea in the sheep, J. Reprod. Fenil. 23: 109.

    Article  CAS  Google Scholar 

  • Diehl, J.R., and Day, B.N., 1973, Effect of prostaglandin Fza on luteal function in swine, J. Anim. Sci. 37: 307.

    Google Scholar 

  • Douglas, R.H., and Ginther, O.J., 1972, Effect of prostaglandin Fza on length of diestrous in mares, Prostaglandins 2: 265.

    CAS  Google Scholar 

  • Douglas, R.H., and Ginther, O.J., 1975a, Effect of prostaglandin F.,a on estrous cycles or corpus luteum in mares and gilts, J. Anim. Sci. 40: 518.

    CAS  Google Scholar 

  • Douglas, R.H., and Ginther, O.J., 19756, Route of prostaglandin F2„ injection and luteolysis in mares, Proc. Soc. Exp. Biol. Med. 145: 263.

    Google Scholar 

  • Douglas, R.H., and Ginther, O.J., 1976, Concentration of prostaglandin F in uterine vein plasma of anesthetized mares during the estrous cycle and early pregnancy, Prostaglandins 11: 251.

    CAS  Google Scholar 

  • Dueben, B.D., Wise, T.H., Bazer, F.W., and Fields, M.J., 1977, Metabolism of H3-progesterone to androgens by pregnant gilt endometrium, Proc. Am. Soc. Anim. Sci., p. 153, Madison, Wisconsin.

    Google Scholar 

  • Dueben, B.D., Wise, T.H., Bazer, F.W., Fields, M.J., and Kalra, P.S. 1979, Metabolism of H3-progesterone to estrogens by pregnant gilt endometrium and conceptus, Proc. Am. Soc. Anim. Sci., p. 293

    Google Scholar 

  • Tuscon, Arizona.du Mesnil du Buisson, F., 1966

    Google Scholar 

  • Contribution a l’étude du maintien du corps jaune de la Truie, Ph.D. dissertation, Institut National de la Recherche Agronomique, Nouzilly, France.du Mesnil du Buisson, F., and Dauzier, L., 1957

    Google Scholar 

  • Controle mutuel de l’uterus et de l’ovaire chez la Truie, Ann. Zootechn. Serie Suppl. D: 147.du Mesnil du Buisson, F., and Leglise, P.C., 1963, Effect de l’hypophysectomie sur les corps jaunes de Truie: Resultats preliminaires, C. R. Acad. Sci. 257:261.

    Google Scholar 

  • Eley, R.M. Thatcher, W.W., and Bazer, F.W., 1979a, Hormonal and physical changes associated with bovine conceptus development, J. Reprod. Fertil. 55:181.

    Google Scholar 

  • Eley, R.M., Thatcher, W.W., and Bazer, F.W., 1979b, Luteolytic effect of estrone sulphate on cyclic beef heifers, J. Reprod. Fertil. 55: 191.

    Article  CAS  Google Scholar 

  • Eley, R.M., Thatcher, W.W., Bazer, F.W., and Fields, M.J., 1979c, Metabolism of progesterone and andresteneditme in vitro by bovine endometrium and conceptus, Proc. Am. Soc. Anim. Sci., p. 294, Tùscon, Arizona.

    Google Scholar 

  • Ellinwood, W.E., 1978, Maternal recognition of pregnancy in the ewe and the rabbit, Ph.D. dissertation, Colorado State University, Fort Collins.

    Google Scholar 

  • Evans, M.J., and Irvine, C.H.G., 1975, Serum concentrations of FSH, LH and progesterone during the estrous cycle and early pregnancy in the mare, J . Reprod. Fertil. Suppl. 23: 193.

    CAS  Google Scholar 

  • Flint, A.P.F., Henville, A., and Christie, W.B., 1979, Presence of placental lactogen in bovine conceptuses before attachment, J . Reprod. Fertil. 56: 305.

    Article  CAS  Google Scholar 

  • Foote, W.D., 1974, Reproductive cycles in cattle, in: Reproduction in Farm Animals ( E.S.E. Hafez, ed.), pp. 257–264, Lea and Febiger, Philadelphia.

    Google Scholar 

  • Frank, M., Bazer, F.W., Thatcher, W.W., and Wilcox, C.J., 1977, A study of prostaglandin F2, as the luteolysin in swine. III. Effects of estradiol valerate on prostaglandin F, progestins, estrone and estradiol concentrations in the utero-ovarian vein of nonpregnant gilts, Prostaglandins 14:1183.

    Google Scholar 

  • Frank, M., Bazer, F.W., Thatcher, W.W., and Wilcox, C.J., 1978, A study of prostaglandin F2, as the luteolysin in swine. IV. An explanation for the luteotrophic effect of estradiol, Prostaglandins 15:151.

    Google Scholar 

  • Ganjam, V.K., Kenney, R.M., and Flickinger, G., 1975, Plasma progestogens in cyclic, pregnant and post-partum mares, J . Reprod. Fertil. Suppl. 23: 441.

    CAS  Google Scholar 

  • Gardener, M.L., First, N.L., and Casida, L.E., 1963, Effect of exogenous estrogens on corpus luteum maintenance in gilts. J . Anim. Sci. 22: 132.

    Google Scholar 

  • Ginther, O.J., and First, N.L., 1971, Maintenance of the corpus luteum in hysterectomized mares, Am. J . Vet. Res. 32: 1687.

    CAS  Google Scholar 

  • Ginther, O.J., Woody, C.O., Janakiraman, K., and Casida, L.E., 1960, Effect of an intrauterine plastic coil on the estrous cycle of the heifers, J . Reprod. Fertil. 12: 193.

    Google Scholar 

  • Gleeson, A.R., Thorburn, G.D., and Cow, R.I., 1974, Prostaglandin F concentrations in the utero-ovarian vein plasma of the sow during the late luteal phase of the estrous cycle, Prostaglandins 5: 521.

    CAS  Google Scholar 

  • Goding, J.R., 1974, The demonstration that PGF,ü is the uterine luteolysin in the ewe, J . Reprod. Fertil. 38: 261.

    Article  CAS  Google Scholar 

  • Godkin, J.D., Cote, C., and Duby, R.T., 1978, Embryonic stimulation of ovine and bovine corpora lutea, J . Reprod. Fertil. 54: 375.

    Article  CAS  Google Scholar 

  • Greenstein, J.S., Murray, R.W., and Foley, R.C., 1958, Effect of exogenous hormones on the reproductive processes of the cycling dairy heifer, J . Dairy Sci. 41:1834 (abstract).

    Google Scholar 

  • Guthrie, H.D., Henricks, D.M., and Handlin, D.L., 1972, Plasma estrogen, progesterone and luteinizing hormone prior to estrus and during early pregnancy in pigs, Endocrinology 91: 675.

    Article  CAS  Google Scholar 

  • Guthrie, H.D., Henricks, D.M., and Handling, D.L., 1974, Plasma hormone levels and fertility in pigs induced to superovulate with PMSG, J . Reprod. Fertil. 41: 361.

    Article  CAS  Google Scholar 

  • Hafs, H.D., Louis, T.M., Noden, P.A., and Oxender, W.D., 1974, Control of the estrous cycle with prostaglandin Fz„ in cattle and horses, J . Anim. Sci. Suppl. 1 38:10. Hallford, D.M., Wettemann, R.P., Turman, E.J., and Omtvedt, I.T., 1974, Luteal function in gilts after prostaglandin Fra, J . Anim. Sci. 38: 213 (abstract).

    Google Scholar 

  • Hansel, W., and Wagner, W.C., 1960, Luteal inhibition in the bovine as a result of oxytocin injections, uterine dilation, and intrauterine infusions of seminal and preputial fluids, J. Dairy Sci. 43: 796.

    Article  Google Scholar 

  • Hansel, W., Concannon, P.W., and Lukaszewska, J.H., 1973, Corpora lutea of large domestic animals, Biol. Reprod. 8: 222.

    CAS  Google Scholar 

  • Hansel, W., Shemesh, M., Hixon, J., and Lukaszewska, J., 1975, Extraction, isolation and identification of a luteolytic substance from bovine endometrium, Biol. Reprod. 13: 30.

    Google Scholar 

  • Harrison, F.A., Heap, R.B., Horton, E.W., and Poyser, N.L., 1972, Identification of prostaglandin F.,„ in uterine fluid from the nonpregnant sheep with an autotransplanted ovary, J. Endocrinol. 53: 215.

    Article  CAS  Google Scholar 

  • Harrison, F.A., Heap, R.B., and Poyser, N.L., 1976, Production, chemical composition and prostaglandin F2, content of uterine fluid in pregnant sheep, J. Reprod. Fertil. 48: 61.

    Article  CAS  Google Scholar 

  • Heap, R.B., and Perry, J.S., 1974, The maternal recognition of pregnancy, Br. J. Hosp. Med. 12:8.

    Google Scholar 

  • Heap, R.B., Flint, A.P.F., Gadsby, J.E., and Rice, C., 1979, Hormones, the early embryo and the uterine environment, J. Reprod. Fertil. 55: 267.

    Article  CAS  Google Scholar 

  • Henderson, K.M., and McNatty, K.P., 1975, A biochemical hypothesis to explain the mechanism of luteal regression, Prostaglandins 9: 779.

    CAS  Google Scholar 

  • Henderson, K.M., Scaramuzzi, R.J., and Baird, D.T., 1977, Simultaneous infusion of prostaglandin Ez antagonizes the luteolytic effect of prostaglandin Fz„ in vivo, J.Endocrinol. 73:379.

    Google Scholar 

  • Henricks, D.M., and Tindall, D.J., 1971, Metabolism of progesterone-4-C“ in porcine uterine endometrium. Endocrinology 89: 920.

    Article  CAS  Google Scholar 

  • Hillman, R.B., and Loy, R.G., 1975, Estrogen excretion in mares in relation to various reproductive states, J. Reprod. Fertil. Suppl. 23: 223.

    CAS  Google Scholar 

  • Hixon, J., and Hansel, W., 1974, Evidence for preferential transfer of prostaglandin Fz„ to the ovarian artery following intrauterine administration in cattle, Biol. Reprod. 11:543. Horton, E.W., and Poyser, N.L., 1976, Uterine luteolytic hormone: A physiological role for prostaglandin F2,,, Physiol. Rev. 56:595.

    Google Scholar 

  • Hoyer, G.L., Colcord, M.L., and Weems, C.W., 1978, Effect of prostaglandin E, (PGE,) on estrogen-induced luteolysis in ewes, Proc. Am. Soc. Anim. Sci., p. 367, East Lansing, Michigan.

    Google Scholar 

  • Inskeep, E.K., Smutny, W.J., Butcher, R.L., and Pexton, J.E., 1975, Effects of intrafollicular injections of prostaglandins in nonpregnant and pregnant ewes, J. Anim. Sci. 41:1098.

    Google Scholar 

  • Kelly, P.A., Robertson, H.A., and Friesen, H.G., 1974, Temporal pattern of placental lactogen and progesterone secretion in sheep, Nature (London) 248: 435.

    Article  CAS  Google Scholar 

  • Kidder, H.E., Casida, L.E., and Grummer, R.H., 1955, Some effects of estrogen injections on the estrual cycle of gilts, J. Anim. Sci. 14: 470.

    CAS  Google Scholar 

  • Kimball, F.A., and Lauderdale, J.W., 1975, Prostaglandin E, and F,(, specific binding in bovine corpora lutea: Comparison with luteolytic effects, Prostaglandins 10:313.

    Google Scholar 

  • Kindahl, H., Edquist, L.E., Bane, A., and Granström, E., 1976, Blood levels of progesterone and 15-keto-13,14-dihydro-prostaglandin F2 during the normal estrous cycle and early pregnancy in heifers, Acta Endocrinol. 82: 134.

    CAS  Google Scholar 

  • Knight, J.W., Bazer, F.W., Thatcher, W.W., Franke, D.E., and Wallace, H.D., 1977, Conceptus development in intact and unilaterally hysterectomized—ovariectomized gilts: Interrelations between hormonal status, placental development, fetal fluids and fetal growth, J. Anim. Sci 44: 620.

    CAS  Google Scholar 

  • Kooistra, L.H., and Ginther, O.J., 1976, Termination of pseudopregnancy by administration of prostaglandin F2 and termination of early pregnancy by administration of prostaglandin Fz„, colchicine or by removal of embryo in mares, Am. J. Vet. Res. 37: 35.

    CAS  Google Scholar 

  • Kraeling, R.R., Barb, C.R., and Davis, B.J., 1975, Prostaglandin induced regression of porcine corpora lutea maintained by estrogen, Prostaglandins 9: 459.

    CAS  Google Scholar 

  • Krzymowski, T., Kotwica, J., Okrasa, S., and Doboszynska, T., 1976, The function and regression of corpora lutea during the sow’s estrous cycle after 10 hrs of prostaglandin Fa, infusion into the anterior uterine vein, Proceedings of the VllIth International Congress on Animal Reproduction and Artificial Insemination, p. 143, Krakow.

    Google Scholar 

  • Kunze, H., and Vogt, W., 1971, Significance of phospholipase A from prostaglandin formation, Ann. N. Y. Acad. Sci. 180: 123.

    Article  CAS  Google Scholar 

  • LaMotte, J.O., 1977, Prostaglandins. I. Presence of a prostaglandin like substance in porcine uterine flushings; 11. A new chemical assay for PGF2 alpha, Diss. Abstr. Mt. B 37: 3798.

    Google Scholar 

  • Lauderdale, J.W., 1974, Distribution and biological effects of prostaglandin, J. Anim . Sci. Suppl. 1 38: 22.

    Google Scholar 

  • Lewis, G.S., Wilson, L., Wilks, J.W., Pexton, J.E., Fogwell, R.L., Ford, S.P., Butcher, R.L., Thayne, W.V., and Inskeep, E.K., 1977, PGF2,„ and its metabolites in uterine and jugular venous plasma and endometrium of ewes during early pregnancy, J. Anim. Sci. 45: 320.

    CAS  Google Scholar 

  • Lewis, G.S., Thatcher, W.W., Bazer, F.W., Roberts, R.M., and Williams, W.F., 1979, Metabolism of arachidonic acid by bovine blastocysts and endometrium, Proc. Am. Soc. Anim. Sci., pp. 313–314, Tucson, Arizona.

    Google Scholar 

  • Loeb, L., 1923, The effect of extirpation of the uterus on the life and function of the corpus luteum in the guinea pig, Proc. Soc. Exp. Bio!. Med. 20: 441.

    Google Scholar 

  • Lovell, J.D., Stabenfeldt, G.H., Hughes, J.P., and Evans, J.W., 1975, Endocrine patterns of the mare at term, J. Reprod. Fertil. Suppl. 23: 449.

    CAS  Google Scholar 

  • Lunaas, T., 1962, Urinary estrogen levels in the sow during estrous cycle and early pregnancy, J. Reprod. Fertil. 4: 13.

    Article  CAS  Google Scholar 

  • Magness, R.R., Huie, J.M., and Weems, C.W., 1978, Effect of contralateral and ipsilateral infusion of prostaglandin E2 (PGE2) on luteal function in the nonpregnant ewe, Proc. Am. Soc. Anim. Sci., p. 376, East Lansing, Michigan.

    Google Scholar 

  • Malven, P.V., and Hansel, W., 1964, Ovarian function in dairy heifers following hysterectomy, J. Dairy Sci. 47: 1388.

    Article  Google Scholar 

  • Mapletoft, R.J., Del Campo, M.R., and Ginther, O.J., 1975, Unilateral luteotropic effect of uterine venous effluent of a gravid uterine horn in sheep, Proc. Soc. Exp. Biol. Med. 150: 129.

    CAS  Google Scholar 

  • Mapletoft, R.J., Del Campo, M.R., and Ginther, O.J., 1976, Local venoarterial pathway

    Google Scholar 

  • for uterine-induced luteolysis in cows, Proc. Soc. Exp. Bio!. Med. 153:289. Mapletoft, R.J., Miller, K.F., and Ginther, O.J., 1977, Effects of PGF2 and PGE2 on

    Google Scholar 

  • corpora lutea in ewes, Proc. Am. Soc. Anim. Sci., p. 185, Madison, Wisconsin. Martal, J., 1978, Placental growth hormone in sheep: Purification, properties and variations

    Google Scholar 

  • Ann. Bio!. Anim. Biochem. Biophys. 18:45.

    Google Scholar 

  • Martal, J., and Djiane, J., 1977, The production of chorionic somatomammotropin in sheep, J. Reprod. Fertil. 49: 285.

    Article  CAS  Google Scholar 

  • Martal, J., and Lacroix, M.C., 1978, Production of chorionic somatomammotropin (oCS), fetal growth and growth of the placenta and corpus luteum in ewes treated with 2bromo-a-ergocryptin, Endocrinology 103: 193.

    Article  CAS  Google Scholar 

  • Martal, J., Lacroix, C., Loudes, C., Saunier, M., and Wintenberger-Torres, S., 1979, Trophoblastin, an antiluteolytic protein present in early pregnancy in sheep, J. Reprod. Fertil. 56: 63.

    Article  CAS  Google Scholar 

  • McCracken, J.A., 1971, Prostaglandin Fla and corpora luteal regression, Ann. N. Y. Acad. Sci. 180: 456.

    Article  CAS  Google Scholar 

  • McCracken, J.A., Carlson, J.C., Glew, M.E., Goding, J.R., Baird, D.T., Green, K., and

    Google Scholar 

  • Samuelsson, B., 1972, Prostaglandin Fz„ identified as a luteolytic hormone in sheep, Nature (London) Ne, v Biol. 238: 129.

    Google Scholar 

  • Melton, A.A., Berry, R.O., and Butter, O.D., 1951, The interval between time of ovulation and attachment of the bovine embryo, J. Anim. Sci. 10: 993.

    Google Scholar 

  • Moeljono, M.P.E., Bazer, F.W., and Thatcher, W.W., 1976, A study of prostaglandin F2„ as the luteolysin in swine. I. Effect of prostaglandin Fz„ in hysterectomized gilts, Prostaglandins 11: 737.

    CAS  Google Scholar 

  • Moeljono, M.P.E., Thatcher, W.W., Bazer, F.W., Frank, M., Owens, L.J., and Wilcox, C.J., 1977, A study of prostaglandin F2„ as the luteolysin in swine. IL Characterization and comparison of prostaglandin F, estrogens and progestin concentrations in utero-ovarian vein plasma of nonpregnant and pregnant gilts, Prostaglandins 14: 543.

    CAS  Google Scholar 

  • Molokwu, E.C., and Wagner, W.C., 1973, Endocrine physiology of the puerperal sow, J. Anim. Sci. 36: 1158.

    CAS  Google Scholar 

  • Moor, R.M., and Rowson, L.E.A., 1966a, The corpus luteum of the sheep: Effect of removal of embryos on luteal function, J. Endocrinol. 34: 497.

    Article  CAS  Google Scholar 

  • Moor, R.M., and Rowson, L.E.A., 1966b, Local maintenance of the corpus luteum in sheep with embryos transferred to various isolated protions of the uterus, J. Reprod. Fertil. 12: 539.

    Article  CAS  Google Scholar 

  • Moor, R.M., and Rowson, L.E.A., 1967, The influence of embryonic tissue homogenate infused into the uterus on the lifespan of the corpus luteum in sheep, J. Reprod. Fertil. 13: 511.

    Article  Google Scholar 

  • Nancarrow, C.D., 1972, Hormonal changes around estrous in the cow, Proc. Airs’’’. Soc. Reprod. Biol. 4: 21.

    Google Scholar 

  • Nett, T.M., Holtan, D.W., and Estergreen, L., 1975, Oestrogens, LH, PMSG and prolactin in serum of pregnant mares, J. Reprod. Fertil. Sapp!. 23: 457.

    CAS  Google Scholar 

  • Nett, T.M., Staigmiller, R.B., Akbar, A.M., Diekman, M.A., Ellinwood, W.E., and Niswender, G.D., 1976, Secretion of prostaglandin F2„ in cycling and pregnant ewes, J. Anim. Sci. 42: 876.

    CAS  Google Scholar 

  • Nishikawa, Y., 1959, Studies in Reproduction in Horses, Shiba Tumuracho Minatoku, Tokyo.

    Google Scholar 

  • Noden, P.A., Hafs, H.D., and Oxender, W.W., 1973, Progesterone, estrus and ovulation

    Google Scholar 

  • after prostaglandin F_„ in horses, Fed Proc. Fed. Am. Soc. Exp. Biol. 32:299. Northey, D.L., and French, L.R., 1978, Effect of embryo removal on bovine interestrus

    Google Scholar 

  • interval, Proc. Am. Soc. Anim. Sci.,p. 380, East Lansing, Michigan.

    Google Scholar 

  • Ogra, S.S., Kirton, K.T., Tomasi, T.B., and Lippes, J., 1974, Prostaglandins in the human fallopian tube, Fertil. Steril. 25: 250.

    CAS  Google Scholar 

  • Palmer, E., and Terqui, M., 1977, The measurement of total plasma estrogens during the follicular phase of the mare’s estrous cycle, Theriogenology 7: 331.

    Article  CAS  Google Scholar 

  • Patek, C.E., and Watson, J., 1976, Prostaglandin F and progesterone secretion by porcine endometrium and corpus luteum in vitro, Prostaglandins 12: 97.

    CAS  Google Scholar 

  • Perry, J.S., Heap, R.B., and Amoroso, E.C., 1973, Steroid hormone production by pig blastocysts, Nature (London) 245: 45.

    Article  CAS  Google Scholar 

  • Perry, J.S., Heap, R.B., Burton, R.D., and Gadsby, J.E., 1976, Endocrinology of the blastocyst and its role in the establishment of pregnancy, J. Reprod. Fertil. Suppl. 25: 85.

    CAS  Google Scholar 

  • Peterson, A.J., Tervit, H.R., Fairclough, R.J., Havik, Y.G., and Smith, J.F., 1976, Jugular levels of 13,14-dihydro-15-keto-prostaglandin F and progesterone around luteolysis and early pregnancy in the ewe, Prostaglandins 12: 551.

    CAS  Google Scholar 

  • Pexton, J.E., Weems, C.W., and Inskeep, E.K., 1975, Prostaglandins F in uterine and

    Google Scholar 

  • ovarian venous plasma from nonpregnant and pregnant ewes collected by cannulation, Prostaglandins 9:501.

    Google Scholar 

  • Pharriss, B.B., and Wyngarden, I.J., 1969, The effect of prostaglandin F2. on the progesterone content of ovaries from pseudopregnant rats, Proc. Soc. Exp. Biol. Med. 130: 92.

    CAS  Google Scholar 

  • Piper, E.L., and Foote, W.C., 1965, A luteotrophic effect of estradiol in the ewe, J. Anim. Sci. 24: 927 (abstract).

    Google Scholar 

  • Raeside, J.I., 1963, Urinary estrogen excretion in the pig during pregnancy and parturition, J. Reprod. Fertil. 6: 427.

    Article  CAS  Google Scholar 

  • Rao, C.V., 1974, Characterization of prostaglandin receptors in the bovine corpus luteum cell membranes, J. Biol. Chem. 249: 7203.

    CAS  Google Scholar 

  • Reddy, S., and Watkins, W.B., 1978, Purification and properties of ovine placental lactogen, J. Endocrinol. 78: 59.

    Article  CAS  Google Scholar 

  • Renfree, M., and Heap, R.B., 1977, Steroid metabolism by the placenta, corpus luteum and endometrium during pregnancy in the marsupial, Macropus eugenii, Theriogenology 8: 164.

    Article  CAS  Google Scholar 

  • Robertson, H.A., and King, G.J., 1974, Plasma concentrations of progesterone, estrone, estradiol-17/3 and of estrone sulphate in the pig at implantation during pregnancy and at parturition, J. Reprod. Fertil. 40: 133.

    Article  CAS  Google Scholar 

  • Robertson, H.A., and King, G.J., 1979, Conjugated and unconjugated estrogens in fetal and maternal fluids of the cow throughout pregnancy, J. Reprod. Fertil. 55: 453.

    Google Scholar 

  • Robertson, H.A., and Smeaton, T., 1973, The concentration of unconjugated estrone, estradiol-17a and estradiol-17/3 in the maternal plasma of the pregnant ewe in relation to the initiation of parturition and lactation, J. Reprod. Fertil. 35: 461.

    Article  CAS  Google Scholar 

  • Saksena, S.K., Lau, I.F., and Chang, M.C., 1976, Relationship between estrogen, prostaglandin Fla and histamine in delayed implantation in the mouse, Acta Endocrinol. 81: 801.

    CAS  Google Scholar 

  • Schomberg, D.W., 1967, A demonstration in vitro of luteolytic activity in pig uterine flushings, J. Endocrinol. 38: 359.

    Article  CAS  Google Scholar 

  • Schomberg, D.W., 1969, The concept of a uterine luteolytic hormone, in: The Gonads ( K.W. McKerns, ed.), pp. 383–397, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Seamans, K.W., Fields, M.J., Bazer, F.W., Vernon, M.W., and Sharp, D.C., 1979, In vitro aromatase activity of pregnant and nonpregnant equine endometrium and conceptus membranes, Proc. Am. Soc. Anim. Sci., p. 335, Tuscon, Arizona.

    Google Scholar 

  • Sharp, D.C., and Black, D.L., 1973, Changes in peripheral plasma progesterone throughout the estrous cycle of the pony mare, J. Reprod. Fertil. 33: 535.

    Article  CAS  Google Scholar 

  • Shemesh, M., and Hansel, W., 1975, Levels of prostaglandin F (PGF) in the bovine endometrium, uterine venous, ovarian artery and jugular plasma during the estrous

    Google Scholar 

  • cycle, Proc. Soc. Exp. Biol. Med. 148:123.

    Google Scholar 

  • Spies, H.G., Zimmerman, D.R., Self, H.L., and Casida, L.E., 1958, Influence of hysterectomy and exogenous progesterone and size and progesterone contact of the corpora lutea in gilts, J. Anim. Sci. 17: 1234 (abstract).

    Google Scholar 

  • Squires, E.L., Wentworth, B.L., and Ginther, O.J., 1974, Progesterone concentration in the blood of mares during the estrous cycle, pregnancy and after hysterectomy, J. Anim. Sci. 39: 759.

    CAS  Google Scholar 

  • Stabenfeldt, G.H., Hughes, J.P., and Evans, J.W., 1972, Ovarian activity during the estrous cycle of the mare, Endocrinology 90:1379.

    Google Scholar 

  • Stormshak, F., Kelley, H.E., and Hawk, H.W., 1969, Suppression of ovine luteal frunction by 17–13 estradiol, J. Anim. Sci. 29: 476.

    CAS  Google Scholar 

  • Terrill, C.E., 1974, Reproductive cycle in sheep, in: Reproduction in Farm Animals ( E.S.E. Hafez, ed.), pp. 265–274, Lea and Febiger, Philadelphia.

    Google Scholar 

  • Thatcher, W.W., and Chenault, J.R., 1976, Reproductive physiological responses of cattle to exogenous prostaglandin Fz„, J. Dairy Sci. 59: 1366.

    Article  CAS  Google Scholar 

  • Thatcher, W.W., Wilcox, C.J., Bazer, F.W., Collier, R.J., Eley, R.M., Stover, D.G., and Bartol, F.F., 1979, Bovine conceptus effects prepartum and potential carryover effects postpartum, Proceedings of the Beltsville Symposium on Animal Reproduction, May 14–17, 1978, Beltsville, Maryland.

    Google Scholar 

  • Thornburn, G.D., Cox, R.I., Currie, W.B., Restall, B.J., and Schnieder, W., 1973, Prostaglandin F and progesterone concentrations in the utero-ovarian venous plasma of the ewe during the estrous cycle and early pregnancy, J. Reprod. Fertil. Suppl. 18: 151.

    Google Scholar 

  • Valdivia, E.O., 1977, Estrogen secretion by the procine conceptus, M.S. thesis, University of Florida, Gainesville.

    Google Scholar 

  • Van Niekerk, C.H., Morgenthal, J.C., and Gerneke, W.H., 1975, Relationship between the morphology of and progesterone production by the corpus luteum of the mare, J. Reprod. Fertil. Suppl. 23: 171.

    Google Scholar 

  • Velle, W., 1960, Early pregnancy diagnosis in the sow, Vet. Rec. 72: 116.

    Google Scholar 

  • Vernon, M.W., 1979, The role of prostaglandins in the utero-ovarian axis of the cycling and early pregnant mare, Ph.D. dissertation, University of Florida, Gainesville.

    Google Scholar 

  • Walker, F.M.M., Patek, C.E., Leaf, C.F., and Watson, J., 1977, The metabolism of prostaglandins Fz„ and Et by nonpregnant porcine endometrial and luteal tissue and early pregnant porcine endometrial tissue, luteal tissue and conceptuses in vitro, Prostaglandins 14: 557.

    CAS  Google Scholar 

  • Warren, J.E., Hawk, H.W., and Bolt, D.J., 1973, Evidence for progestational priming of estradiol induced luteal regression in the ewe, Biol. Reprod. 8: 435.

    CAS  Google Scholar 

  • Wettemann, R.P., Hallford, D.M., Kreider, D.L., and Turman, E.J., 1974, Parturition in swine after prostaglandin F2, J. Anim. Sci. 39: 228 (abstract).

    Google Scholar 

  • Willis, M.C., Fields, M.J., Wise, T.H., Dueben, B.D., and Bazer, F.W., 1979a, ln vitro metabolism of H3-progesterone to androgens and estrogens by pregnant sheep endometrium, Proc. Am. Soc. Anim. Sci., p. 350, Tuscon, Arizona.

    Google Scholar 

  • Willis, M.C., Fields, M.J., Wise, T.H., Dueben, B.D., and Bazer, F.W., 19796, Ln vitro metabolism of H3-progesterone to androgens and estrogens by pregnant sheep endometrium and conceptus membranes, Proc. Am. Soc. Anim. Sci.,p. 350, Tuscon, Arizona.

    Google Scholar 

  • Wilson, J.D., 1972, Recent studies on the mechanism of action of testosterone, N. Engl. J. Med. 287: 1284.

    Article  CAS  Google Scholar 

  • Wilson, L., Butcher, R.L., and Inskeep, E.K., 1972, Prostaglandin F2, in the uterus of ewes during early pregnancy, Prostaglandins 1: 479.

    CAS  Google Scholar 

  • Wiltbank, J.N., and Casida, L.E., 1956, Alteration of ovarian activity by hysterectomy, J. Anim. Sci. 15: 134.

    Google Scholar 

  • Wiltbank, J.N., Ingalls, J.E., and Rowden, W.W., 1961, Effects of various forms and levels of estrogen alone or in combinations with gonadotropins on the estrous cycle of beef heifers, J. Anim. Sci. 20: 341.

    CAS  Google Scholar 

  • Young Lai, E.V., 1971, Steroid content of the equine ovary during the reproductive cycle, J. Endocrinol. 50: 589.

    Article  Google Scholar 

  • Zavy, M.T., Bazer, F.W., and Sharp, D.C., 1978a, A nonsurgical technique for the collection of uterine fluid from the mare, J. Anim. Sci. 47: 672.

    CAS  Google Scholar 

  • Zavy, M.T., Bazer, F.W., Sharp, D.C., Frank, M., and Thatcher, W.W., 1978b, Uterine luminal prostaglandin F in cycling mares, Prostaglandins 16: 643.

    CAS  Google Scholar 

  • Zavy, M.T., Bazer, F.W., Sharp, D.C., and Wilcox, C.J., 1979a, Uterine luminal proteins in the cycling mare, Biol. Reprod. 20: 689.

    Article  CAS  Google Scholar 

  • Zavy, M.T., Bazer, F.W., Sharp, D.C., and Thatcher, W.W., 1979b, Endocrine aspects of the uterine environment in nonpregnant and pregnant gilts Proc. Am. Soc. Anim. Sci.pp. 351–352, Thscon, Arizona.

    Google Scholar 

  • Zavy, M.T., Mayer, R., Vernon, M.W., Bazer, R.W., and Sharp, D.C., 1979c, An investigation of the uterine luminal environment of nonpregnant and pregnant pony mares, J. Reprod. Fertil. Suppl. 27: 403.

    Google Scholar 

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Authors and Affiliations

  1. Department of Animal Science, University of Florida, Gainesville, Florida, 32611, USA

    Fuller W. Bazer & D. C. Sharp III

  2. Department of Dairy Science, University of Florida, Gainesville, Florida, 32611, USA

    W. W. Thatcher

  3. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, 32611, USA

    R. Michael Roberts

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  1. Fuller W. Bazer
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  2. D. C. Sharp III
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  3. W. W. Thatcher
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  4. R. Michael Roberts
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Editors and Affiliations

  1. The International Society for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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Bazer, F.W., Sharp, D.C., Thatcher, W.W., Roberts, R.M. (1981). Comparative Approach to Mechanisms in the Maintenance of Early Pregnancy. In: McKerns, K.W. (eds) Reproductive Processes and Contraception. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3824-6_27

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  • DOI: https://doi.org/10.1007/978-1-4684-3824-6_27

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