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Regulation of LH-RH Secretion by Gonadal Steroids and Catecholamines

  • Chapter
Reproductive Processes and Contraception

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

The presence of a hypothalamic factor that stimulates the release of pituitary luteinizing hormone (LH) was demonstrated two decades ago (McCann et al., 1960). A great deal of effort was directed toward the purification and chemical identification of the hypothalamic LH-releasing hormone (LH-RH). Matsuo et al. (1971) characterized the chemical structure of the naturally occurring LH-RH and showed it to be biologically and chemically identical with the synthetic decapeptide. Antibodies against the synthetic decapeptide were produced for the radioimmunoassay of LH-RH in tissue and body fluids (Nett et al.,1973). Recently, the distribution of the LH-RH neuronal network in the brain has been investigated by a variety of techniques including bioassay and radioimmunoassay and by immunocytochemical means (Naik, 1975; Elde and Hökfelt, 1978; Hoffman et al., 1978; Sétáló et al., 1978).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida, 32610, USA

    Satya P. Kalra, Pushpa S. Kalra & J. W. Simpkins

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  1. Satya P. Kalra
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  2. Pushpa S. Kalra
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  3. J. W. Simpkins
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Editors and Affiliations

  1. The International Society for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1981 Plenum Press, New York

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Kalra, S.P., Kalra, P.S., Simpkins, J.W. (1981). Regulation of LH-RH Secretion by Gonadal Steroids and Catecholamines. In: McKerns, K.W. (eds) Reproductive Processes and Contraception. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3824-6_2

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  • DOI: https://doi.org/10.1007/978-1-4684-3824-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3826-0

  • Online ISBN: 978-1-4684-3824-6

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