Skip to main content

The Enigma of Good Kidney-Graft Survival in the Face of Poor HLA Matches

HLA Matching for Kidney Transplantation Makes Sense

  • Chapter
Current Trends in Histocompatibility
  • 24 Accesses

Abstract

One of the few facts all those involved in kidney allografting agreed on almost from the beginning is that matching for the HLA system plays an overriding role when donor and recipient are siblings. It was one of the fundamental observations that identified the HLA system as the major histocompatibility complex (MHC).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albrechtsen, D., Solheim, B.G., and Thorsby, E., 1977, Antiserum inhibition of the mixed lymphocyte culture (MLC) interaction: Inhibitory effect of antibodies reactive with HLA-D associated determinants, Cell. Immunol. 25:258.

    Article  Google Scholar 

  • Albrechtsen, D., Flatmark, A., Jervell, J., Solheim, G., and Thorsby, E., 1978, HLA-DR antigen matching in cadaver renal transplantation, Lancet 1:825.

    Article  PubMed  CAS  Google Scholar 

  • Beizer, F.O., Perkins, H.A., Fortmann, J.L., Kountz, S.L., Salvaterro, O., Cochrum, K.C., and Payne, R., 1974, Is HL-A typing of clinical significance in cadaver renal transplantation?, Lancet 1:774.

    Google Scholar 

  • Bradley, B.A., and Festenstein, H., 1978, Cellular typing, Br. Med. Bull. 34:223.

    PubMed  CAS  Google Scholar 

  • Brynger, H., Frisk, B., Ahlmén, J., Blohmé, I., and Sandberg, L., 1977. Blood transfusion and primary graft survival in male recipients, Scand. J. Urol. Nephrol. Suppl. 42:76.

    PubMed  Google Scholar 

  • Claas, F.H.J., van Rood, J.J., Warren, R.P., Weiden, P.L., Su., P.J., and Storb, R., 1979, The detection of non-HLA antibodies and their possible role in bone marrow graft rejection, Transplant. Proc. 11:423.

    PubMed  CAS  Google Scholar 

  • Cochrum, K., Perkins, H.A., Payne, R.O., Kountz, S., and Beizer, F., 1973, The correlation of MLC with graft survival, Transplant. Proc. 5:391.

    PubMed  CAS  Google Scholar 

  • Dausset, J., Hors, J., Busson, M., Festenstein, H., Oliver, R.T.D., Paris, A.M.I., and Sachs, J.A., 1974, A joint analysis performed by France-Transplant and the London Transplant group, N. Engl. J. Med. 290:979.

    Article  PubMed  CAS  Google Scholar 

  • Diepenhorst, P., Sprokholt, R., and Prins, H.K., 1972, Removal of leukocytes from whole blood and erythrocyte suspensions by filtration through cotton-wool. I. Filtration technique, Vox Sang. 23:308.

    Article  PubMed  CAS  Google Scholar 

  • Festenstein, H., Sachs, J.A., and Paris, A.M.I., 1976, Influence of HLA matching and blood transfusion on outcome of 502 London Transplant group renal-graft recipients, Lancet 1:157.

    Article  PubMed  CAS  Google Scholar 

  • Fotino, M., and Allen, F.H., 1972, A shared HL-A haplotype seems to make a cadaver donor satisfactory for kidney transplantation, Vox Sang. 22:309.

    Article  PubMed  CAS  Google Scholar 

  • Goulmy, E., Bradley, B.A., Lansbergen, Q., and van Rood, J.J., 1978, The importance of H-Y incompatibility in human organ transplantation, Transplantation 25:315.

    Article  PubMed  CAS  Google Scholar 

  • Hamburger, J., Crosnier, J., Descamps, B., and Rowinska, D., 1971, The value of present methods used for the selection of organ donors, Transplant. Proc. 3:260.

    PubMed  CAS  Google Scholar 

  • Histocompatibility Testing 1977 (W.F. Bodmer et al., eds.), 1978, Munksgaard, Copenhagen.

    Google Scholar 

  • Hors, J., Busson, M., and Dausset, J., 1974, Rôle des incompatibilités HL-A et de la pre-immunisation en transplantation rénale, in: Proceedings of the 5th International Course on Transplantation, Lyon, 1973 (J.P. Revillard, ed.), pp. 19–30, Simep-Editions, Villeurbanne.

    Google Scholar 

  • Hurme, M., Hetherington, C.M., Chandler, P.R., and Simpson, E., 1978, Cytotoxic T-cell responses to H-Y: Mapping of the Ir genes, J. Exp. Med. 147:758.

    Article  PubMed  CAS  Google Scholar 

  • Iwaki, Y., Terasaki, P.I., Park, M.S., and Billing, R., 1978, Enhancement of human kidney allografts by cold B-lymphocyte cytotoxins, Lancet 1:1228.

    Article  PubMed  CAS  Google Scholar 

  • Jeannet, M., 1970, Histocompatibility testing using leukocyte typing and mixed lymphocyte culture in kidney transplants, Helv. Med. Acta 35:168.

    PubMed  CAS  Google Scholar 

  • Jonker, M., and van Rood, J.J., 1978, Can anti-HLA-A and-B antigens inhibit the MLC test?, Tissue Antigens 11:251.

    Article  PubMed  CAS  Google Scholar 

  • Martins-da-Silva, B., Vassalli, P., and Jeannet, M., 1978, Matching renal grafts, Lancet 1:1047 (letter to the editor).

    Google Scholar 

  • Moraes, J.R., and Stastny, P., 1977, A new antigen system expressed in human endothelial cells, J. Clin. Invest. 60:449.

    Article  PubMed  CAS  Google Scholar 

  • Morris, P.J., Bishop, M., Fellows, G., Ledingham, J.G., Ting, A., Oliver, D., Cullen, P., French, M., Smith, J.C., and Williams, K., 1978, Results from a new renal transplantation unit, Lancet 2:1353.

    Article  PubMed  CAS  Google Scholar 

  • Oliver, R.T.D., Sachs, J.A., Festenstein, H., Pegrum, G.D., and Moorhead, J.F., 1972, Influence of HL-A matching antigenic strength and immune responsiveness on the outcome of 349 cadaver renal grafts, Lancet 2:381.

    Google Scholar 

  • Opelz, G., and Terasaki, P.I., 1978, Improvement of kidney-graft survival with increased numbers of blood transfusions, N. Engl. J. Med. 299:799.

    Article  PubMed  CAS  Google Scholar 

  • Opelz, G., Sengar, D.P., Mickey, M.R., and Terasaki, P.I., 1973, Effect of blood transfusions on subsequent kidney transplants, Transplant. Proc. 5:253.

    PubMed  CAS  Google Scholar 

  • Oriol, R., Cartron, J., Yvart, J., Bedrossian, J., Duboust, A., Bariety, J., Gluckman, J.C., and Gagnadoux, M.F., 1978, The Lewis system: New histocompatibility antigens in renal transplantation, Lancet 1:574.

    Article  PubMed  CAS  Google Scholar 

  • Paul, L.C., van Es, L.A., van Leeuwen, A., van Rood, J.J., de Graeff, J., and Brutel de la Rivière, G., 1979, Antibodies directed against antigens on the endothelium of peritubular capillaries in patients rejecting renal allografts, Transplantation 27:175.

    Article  PubMed  CAS  Google Scholar 

  • Persijn, G.G., van Hooff, J.P., Kalff, M.W., Lansbergen, Q., and van Rood, J.J., 1977, Effect of blood transfusion and HLA matching on renal transplantation in the Netherlands, Transplant. Proc. 9:503.

    PubMed  CAS  Google Scholar 

  • Persijn, G.G., Gabb, B.W., van Leeuwen, A., Nagtegaal, A., Hoogeboom, J., and van Rood, J.J., 1978, Matching for HLA antigens of A, B and DR loci in renal transplantation by Eurotransplant, Lancet 1:1278.

    Article  PubMed  CAS  Google Scholar 

  • Persijn, G.G., Cohen, B., and van Rood, J.J., 1979, Eurotransplant: Improved graft survival through HLA-A,-B and-DR matching and prospective blood transfusion policy, Dialysis Transplant. 8:493.

    Google Scholar 

  • Shearer, G.M., 1974, Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes, Eur. J. Immunol. 4:527.

    Article  PubMed  CAS  Google Scholar 

  • Solheim, B., Flatmark, A., Jervell, J., and Arnesen, E., 1977, Influence of blood transfusions on kidney transplant and uremic patient survival, Scand. J. Urol. Nephrol. Suppl. 42:65.

    PubMed  Google Scholar 

  • Starzl, T.E., Marchioro, T.L., Hermann, G., Brittain, R.S., and Waddell, W.R., 1964, Renal homografts in patients with major donor-recipient blood group incompatibilities, Surgery 55:195.

    PubMed  CAS  Google Scholar 

  • Stenzel, K.H., Shitsell, J.C., Cheigh, J.S., Riggio, R.R., Stubenborg, W.T., Sullivan, J.F., Rubin, A.L., and Fotino, M., 1974, Effects of HL-A matching and immune responsiveness on cadaver kidney graft survival, Transplant. Proc. 6:89.

    PubMed  CAS  Google Scholar 

  • Stiller, C.R., Sinclair, N.R., Sheppard, R.R., Lockwood, B.L., Ulan, R.A., Sharpe, J.A., and Hayman, P., 1978, Beneficial effect of operation-day blood transfusions on human renal-allograft survival, Lancet 1:169.

    Article  PubMed  CAS  Google Scholar 

  • Storb, R., Prentice, R.L., and Thomas, E.D., 1977, Treatment of aplastic anemia by marrow transplantation from HLA identical siblings: Prognostic factors associated with graft-versus-host disease and survival, J. Clin. Invest. 59:625.

    Article  PubMed  CAS  Google Scholar 

  • Termijtelen, A., Bradley, B.A., and van Rood, J.J., 1977, The influence of HLA-A and-B associated gene products on typing for HLA-D by the HTC and PLT methods, Tissue Antigens 10:161.

    Google Scholar 

  • Thomas, J., Thomas, F., and Lee, H.M., 1977, Why do HLA-nonidentical renal allografts survive 10 years or more?, Transplant. Proc. 9:85.

    PubMed  CAS  Google Scholar 

  • Thompson, J.S., Jackson, D., Greazel, N.A., Parmely, M.J., and Severson, C.D., 1976, Antileukocyte antibody in postpartum and renal transplant subjects: A comparison of capillary agglutination and lymphocytotoxicity reactions, Transplantation 21:85.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, J.S., Corry, R.J., Lawton, R.L., Bonney, W.W., and Kaloyanides, G.J., 1977a, Effect of prospective HLA-haplotype matching on renal transplantation, Transplant. Proc. 9:205.

    PubMed  CAS  Google Scholar 

  • Thompson, J.S., Severson, C.D., Greazel, N.A., and Ferrone, S., 1977b, Detection of HLA (Ia) and non-HLA specificities by “B-cell” antisera, Transplant. Proc. 9:597.

    PubMed  CAS  Google Scholar 

  • Ting, A., and Morris, P.J., 1978, Matching for B-cell antigens of the HLA-DR series in cadaver renal transplantation, Lancet 1:575.

    Article  PubMed  CAS  Google Scholar 

  • Transplantation Proceedings, 1977, Vol. 9.

    Google Scholar 

  • Troup, G.M., Jameson, J., Thomsen, M., Svejgaard, A., and Walford, R.L., 1978, Studies of HLA alloantigens of the Navajo Indians of North America. I. Variance of association between HLA-DRw (WIA) and HLA-DW specificities, Tissue Antigens 12:44.

    PubMed  CAS  Google Scholar 

  • van Es, A.A., Marquet, R.L., van Rood, J.J., Kalff, M.W., and Balner, H., 1977, Blood transfusions induce prolonged kidney allograft survival in rhesus monkeys, Lancet 1:506.

    PubMed  Google Scholar 

  • van Hooff, J.P., Hendriks, G.F.J., Schippers, H.M.A., and van Rood, J.J., 1974, The influence of possible HL-A haploidentity on renal graft survival in Eurotransplant, Lancet 1:1130.

    Article  PubMed  Google Scholar 

  • van Hooff, J.P., Kalff, M.W., van Poelgeest, A.E., Persijn, G.G., and van Rood, J.J., 1976, Blood transfusions and kidney transplantation, Transplantation 22:306.

    Article  Google Scholar 

  • van Rood, J.J., 1967, A proposal for international cooperation in organ transplantation: Eurotransplant, in: Histocompatibility Testing 1967 (E.S. Curtoni, P.L. Mattiuz, and R.M. Tosi, eds.), pp. 451–458, Munksgaard, Copenhagen.

    Google Scholar 

  • van Rood, J.J., van Leeuwen, A., and Bruning, J.W., 1967, The relevance of leucocyte antigens for allogenic renal transplantation, J. Clin. Pathol. Suppl. 20:504.

    Google Scholar 

  • van Rood, J.J., van Leeuwen, A., Termijtelen, A., and Bradley, B.A., 1978, HLA-D rally won by serology, in: Histocompatibility Testing 1977 (W.F. Bodmer, J.R. Batchelor, J.G. Bodmer, H. Festenstein, and P.J. Morris, eds.), p. 403, Munksgaard, Copenhagen.

    Google Scholar 

  • van Rood, J.J., Persijn, G.G., van Leeuwen, A., Goulmy, E., and Gabb, B.W., 1979, A new strategy to improve kidney graft survival: The induction of CML non-responsiveness, Transplant. Proc. 11:736.

    PubMed  Google Scholar 

  • von Boehmer, H., Fathman, C.G., and Haas, W., 1977, H-2 gene complementation in cytotoxic T cell responses of female against male cells, Eur. J. Immunol. 7:443.

    Article  Google Scholar 

  • Wonigeit, K., and Pichlmayr, R., 1977, Specific defect in the capability to generate cytotoxic effector cells in vitro after organ transplantation in man, Dialysis Transplant. 6:58.

    Google Scholar 

  • Zinkernagel, R.M., and Doherty, P.C., 1974, Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system, Nature (London) 248:701.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer Science+Business Media New York

About this chapter

Cite this chapter

van Rood, J.J., Persijn, G.G., Goulmy, E., Bradley, B.A. (1981). The Enigma of Good Kidney-Graft Survival in the Face of Poor HLA Matches. In: Reisfeld, R.A., Ferrone, S. (eds) Current Trends in Histocompatibility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3761-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3761-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3763-8

  • Online ISBN: 978-1-4684-3761-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics