Abstract
The immune response is a reaction to a foreign or nonself substance. Intricately involved in this highly specific and tightly regulated protective-reaction mechanism are the gene products of the major histocompatibility complex (MHC) (Klein, 1975; Snell et al., 1976; Paul and Benacerraf, 1977; Götze, 1977; Snell, 1978). This genetic system was referred to as the H-2 locus when it was initially recognized as a determinant of transplantation acceptance or rejection nearly 45 years ago by P.A. Gorer (1936). The serological and genetic features were gradually unraveled over the ensuing years. The complexity, both in terms of number of genes and in terms of polymorphism, led to the use of the term H-2 major histocompatibility complex to refer to this chromosomal region in the mouse. Similar MHC complexes have been found in other species (Götze, 1977).
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Nathenson, S.G., Ewenstein, B.M., Uehara, H., Martinko, J.M., Coligan, J.E., Kindt, T.J. (1981). Structure of H-2 Major Histocompatibility Complex Products. In: Reisfeld, R.A., Ferrone, S. (eds) Current Trends in Histocompatibility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3758-4_17
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DOI: https://doi.org/10.1007/978-1-4684-3758-4_17
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