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Serological Testing of the HLA Antigens

Problems and Approaches to Standardization

  • Chapter
Current Trends in Histocompatibility

Abstract

In recent years, the demand for HLA testing has increased greatly, to the extent that it has outpaced the capacity of HLA-typing laboratories to adequately fulfill this need. This is due, in part, to an increasing application of HLA typing not only to organ and tissue transplantation, but also to granulocyte and platelet transfusion (Mittal et al., 1976). To provide optimally HLA-matched platelets to various thrombocytopenic patients, it is necessary that large numbers of potential donors be HLA-phenotyped prospectively.

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References

  • Ahrons, S., and Glavind-Kristensen, 1971, Cytotoxic HLA antibodies: Immunoglobulin Classification, Tissue Antigens 1:129.

    Article  PubMed  CAS  Google Scholar 

  • Arnos, B., and Yunis, E., 1968, Human leukocyte antigenic specificity HL-A3: Frequency of occurrence, Science 165:300.

    Google Scholar 

  • Bach, J.F., 1975, The Mode of Action of Immunosuppressive Agents (A. Neuberger and E.L. Tatum, eds.), pp. 1–374, North-Holland, Amsterdam.

    Google Scholar 

  • Bernoco, D., Bernoco, M., Ceppellini, R., Poulik, M.D., van Leeuwen, A., and van Rood, J.J., 1976, B cell antigens of the HLA system: A simple serotyping technique based on non-cytotoxic anti-β 2-microglobulin reagents, Tissue Antigens 8:253.

    PubMed  CAS  Google Scholar 

  • Ceppellini, R., Curtoni, E.S., Mattiuz, P.L., Miggiano, V., Scudeller, G., and Serra, A., 1967, Genetics of leukocyte antigens: A family study of segregation and linkage, in: Histocompatibility Testing 1967 (E.S. Curtoni, P.L. Mattiuz, and R.M. Tosi, eds.), pp. 149–187, Munksgaard, Copenhagen.

    Google Scholar 

  • Dausset, J., Legrand, L., Lepage, V., Contu, L., Marcelli-Barge, A., Wildloecher, I., Benajam, A., Meo, T., and Degos, L., 1978, A haplotype study of HLA complex with special reference to the HLA-DR series and to Bf, C2 and Glyoxalase I polymorphisms, Tissue Antigens 12:297.

    Article  PubMed  CAS  Google Scholar 

  • Einstein, A.B., Mann, D.L., Gordon, H.G., Trapani, R., and Fahey, J.L., 1971, Heterologous antisera against specific HLA antigens, Transplantation 12:299.

    Article  PubMed  Google Scholar 

  • Ferrara, G.B., Tosi, R., Longo, A., Castellani, A., Viviani, C., and Carmainati, G., 1978, A safe blood transfusion procedure for immunization against major histocompatibility complex determinants in man, Transplantation 26:150.

    Article  PubMed  CAS  Google Scholar 

  • Ferrone, S., 1977, Rabbit complement in the lymphocytotoxicity test, Tissue Antigens 9:223.

    Article  PubMed  CAS  Google Scholar 

  • Ferrone, S., Tosi, R.M., and Centis, D., 1967, Anticomplementary factors affecting thelymphocytotoxicity test, in: Histocompatibility Testing 1967 (E.S. Curtoni, P.L. Mattiuz, and R.M. Tosi, eds.),pp. 357–364, Munksgaard, Copenhagen.

    Google Scholar 

  • Ferrone, S., Mittal, K.K., Pellegrino, M.A., Allison, J.P., and Reisfeld, R.A., 1977, Immunogenicity of HLA antigens purified from serum, Transplantation 23:7.

    Article  PubMed  CAS  Google Scholar 

  • Galfre, G., Howe, S.C., Milstein, C., Butcher, G.W., and Howard, J.C., 1977, Antibodies to major histocompatibility antigens produced by hybrid cell lines, Nature (London) 266:550.

    Article  CAS  Google Scholar 

  • Jerne, N.K., 1971, The somatic generation of immune recognition, Eur. J. Immunol. 1:1.

    Article  PubMed  CAS  Google Scholar 

  • Legrand, L., and Dausset, J., 1972, Serological evidence of the existence of several antigenic determinants (or factors) on the HLA gene products, in: Histocompatibility Testing 1972 (J. Dausset and J. Colombani, eds.), pp. 441–453, Munksgaard, Copenhagen.

    Google Scholar 

  • Legrand, L., and Dausset, J., 1974, The complexity of the HLA gene product, Tissue Antigens 4:329.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., 1975, Cross-reactivity of monospecific anti-HL-A antisera, Vox Sang. 29:418.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., 1976, The HLA polymorphism and susceptibility to disease, Vox Sang. 31:161.

    Article  PubMed  Google Scholar 

  • Mittal, K.K., 1977, Possible mechanisms for association of HLA antigens and disease, in: HLA and Malignancy, (G.P. Murphy, E. Cohen, J.E. Fitzpatrick, and D. Pressman, eds.), pp. 39–51, Alan R. Liss, New York.

    Google Scholar 

  • Mittal, K.K., 1978, Standardization of the HLA typing method and reagents, Transplantation 25:275.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., and Terasaki, P.I., 1974, Serological cross-reactivity in the HLA system, Tissue Antigens 4:146.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., Mickey, M.R., Singal, D.P., and Terasaki, P.L, 1968, Serotyping for homo-transplantation. XVIII. Refinement of microdroplet lymphocyte cytotoxicity test, Transplantation 6:913.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., Rossen, R.D., and Butler, W.T., 1970, Evaluation of HLA serum specificity and lymphocyte reactivity, in: Histocompatibility Testing 1970 (P.I. Terasaki, ed.), pp. 343–349, Munksgaard, Copenhagen.

    Google Scholar 

  • Mittal, K.K., Mickey, M.R., and Terasaki, P.I., 1971, Heterogeneity of HL-A specificities shown by platelet complement fixation, Tissue Antigens 1:279.

    Article  PubMed  CAS  Google Scholar 

  • Mittal, K.K., Ruder, A., and Green, D., 1976, Matching of histocompatibility (HL-A) antigens for platelet transfusion, Blood 47:31.

    PubMed  CAS  Google Scholar 

  • Mittal, K.K., Fraize, L.E., and Kaur, D., 1977, Strength and specificity in the workshop HLA antisera, Tissue Antigens 10:186.

    Google Scholar 

  • Mittal, K.K., Fraize, L.E., and Kaur, D., 1978, Specificity and potency in the workshop HLA antisera, in: Histocompatibility Testing 1977 (W.F. Bodmer, J.R. Batchelor, J.G. Bodmer, H. Festenstein, and P.J. Morris, eds.), pp. 578–580, Munksgaard, Copenhagen.

    Google Scholar 

  • Parham, P., and Bodmer, W.F., 1978, Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2, Nature (London) 276:397.

    Article  CAS  Google Scholar 

  • Payne, R., Amos, B., Kostyu, D., Engelfriet, C.P., van den Berg-Loonen, P.M., Curtoni, E.S., and Richiardi, P., 1978, Subdivisions of the HLA-B5 and Bw35 complex, Tissue Antigens 11:302.

    Article  PubMed  CAS  Google Scholar 

  • Poulik, M.D., Ferrone, S., Pellegrino, M.A., Sevier, D.E., Oh, S.K., and Reisfeld, R.A., 1974, Association of HLA antigens and β 2-microglobulin: Concepts and questions, Transplant. Rev. 21:106.

    PubMed  CAS  Google Scholar 

  • Reisner, E.G., Legrand, L., and Dausset, J., 1976, Specificities shared between HLA-A3 and HLA-A11 detected by Fab’2 blocking, Immunogenetics 3:233.

    Article  Google Scholar 

  • Rice, C.E., 1948, Inhibitory effects of certain avian and mammalian antisera in specific complement fixation systems, J. Immunol. 59:365.

    PubMed  CAS  Google Scholar 

  • Selwood, N.H., 1972, Definition of specificity and the analysis of HL-A reagents by a computerised numerical method, Tissue Antigens 2:147.

    Article  PubMed  CAS  Google Scholar 

  • Snell, G.D., 1978, T cells, T cell recognition structures, and major histocompatibility complex, Immunol. Rev. 38:3.

    Article  PubMed  CAS  Google Scholar 

  • Snell, G.D., Dausset, J., and Nathenson, S., 1976, The HLA complex: Serology and genetics, in: Histocompatibility, pp. 181–247, Academic Press, New York.

    Google Scholar 

  • Svejgaard, A., and Kissmeyer-Nielsen, F., 1968, Cross-reactive human HLA iso-anti-bodies, Nature (London) 219:868.

    Article  CAS  Google Scholar 

  • Terasaki, P.I., 1978, Resolution by HLA testing of 1,000 paternity cases not excluded by ABO testing, J. Family Law 16:543.

    Google Scholar 

  • Thompson, J.S., Severson, C.D., Mickey, M.R., Braun, W.E., and Gatti, R.A., 1978, HLA-A, B, and D associations with B-cell antigen DRw7, Tissue Antigens 12:350.

    Article  PubMed  CAS  Google Scholar 

  • van Rood, J.J., and Eernisse, J.G., 1968, The detection of transplantation antigens in leukocytes, Semin. Hematol. 5:187.

    PubMed  Google Scholar 

  • Zinkernagel, R.M., and Doherty, P.C., 1975, H-2 compatibility requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus, J. Exp. Med. 141:1427.

    Article  PubMed  CAS  Google Scholar 

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Mittal, K.K., Kaur, D. (1981). Serological Testing of the HLA Antigens. In: Reisfeld, R.A., Ferrone, S. (eds) Current Trends in Histocompatibility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3758-4_10

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  • DOI: https://doi.org/10.1007/978-1-4684-3758-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3760-7

  • Online ISBN: 978-1-4684-3758-4

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