Abstract
In the 1960s, Ames and his coworkers (1–4), described an obstructive process in cerebral microvessels that followed periods of experimental stasis as short as 7 minutes. Called no-reflow, the phenomenon was of interest because it appeared within the time frame of the development of an irreversible ischemic brain injury. Subsequent study has led to the belief that the obstruction is caused mainly by sludging of erythrocytes and can be overcome by a blood pressure pulse of approximately 100 mmHg in the immediate postischemic period. Once flow is restarted, autoregulation, however, is lost so that the passive dependence of flow on pressure results in postischemic cerebral blood flows of more than twice preischemic levels when blood pressure is restored to the preischemic value (5).
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References
Ames A III, Wright RL, Kowada M, et al: Cerebral ischemia: II. The no-reflow phenomenon. Am J Pathol 52: 437–453, 1968.
Cantu RC, Ames A III: Experimental prevention of cerebral vascular obstruction produced by ischemia. J Neurosurg 30: 50–54, 1969.
Fischer EG: Impaired perfusion following cerebral vascular stasis. Arch Neurol 29: 361–366, 1973.
Kowada M, Ames A, Majno G, et al: Cerebral ischemia: I. An improved experimental method for study: Cardiovascular effects and demonstration of an early vascular lesion in the rabbit. J Neurosurg 28: 150–157, 1968.
Fischer EG, Ames A III, Lorenzo AV: Cerebral blood flow immediately following brief circulatory stasis. Stroke 10: 423–427, 1979.
Fischer EG, Ames A III: Studies on mechanisms of impairment of cerebral circulation following ischemia: Effect of hemodilution and perfusion pressure. Stroke 3: 538–542, 1972.
Harrison MJG, Sedal L, Arnold J, et al: No-reflow phenomenon in the cerebral circulation of the gerbil. J Neurol Neurosurg, Psychiat 38: 1190–1193, 1975.
Cuypers J, Matakas F: The effect of post-ischemic hyperemia on intracranial pressure and the no-reflow phenomenon. Acta Neuropath (Berl) 29: 73–84, 1974.
Ginsberg MO, Myers RE: The topography of impaired micro vascular perfusion in the primate brain following total circulatory arrest. Neurology 22: 998–1011, 1972.
Diethelon AG: Effect of ischemia upon renal microcirculation: Preliminary observations. Am Surg 35: 833–835, 1969.
Kovacs K, Carroll R, Tapp E: Temporary ischemia of the rat adrenal gland. J Path Bact 91: 235–240, 1966.
Krug A, deRochemont W, Karb B: Blood supply of the myocar dium after temporary coronary occlusion. Circ Res 19: 57–62, 1966.
Sheehan HC, Davis JC: Renal ischemia with failed reflow. J Pathol 78: 105, 1971.
Strock PE, Majno G: Microvascular changes in acutely ischemic rat muscle. Surg Gynecol Obstet 129:1213- 1224, 1969.
Willms-Kretschmer K, Majno G: Ischemia of the skin. Am J Pathol 54: 327–353, 1969.
Cantu RCc Ames A III, Dixon J, et al: Reversibility of experimental cerebrovascular obstruction induced by complete ischemia. J Neurosurg 31: 429–431, 1969.
Fischer EG, Ames A III, Hedley-Whyte ET, et al: Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the “no-reflow phenomenon”. Stroke 8: 36–39, 1977.
Merrill EW, Meiselman HJ, Gilliland ER, et al: Flow of human blood in glass and plastic fibers: A filmed study. In, Wolstenholme GEW and Knight J (eds): DIBA Foundation Symposium on Circulatory and Respiratory Mass Transport, London, J & A Churchill, 1969, pp 130–131.
Merrill EW: Rheology of blood. Physiol Rev 49: 863–888, 1969.
Chiang J, Kowada M, Ames A III, et al: Cerebral ischemia: III. Vascular changes. Am J Pathol 52: 455–476, 1968.
Nemoto EM, Snyder JV, Carroll RG, et al: Global ischemia in dogs: Cerebrovascular CO2 reactivity and autoregula- tion. Stroke 6: 425–431, 1975.
Takagi S, Cocito L, Hossman DH: Blood recirculation and pharmacological responsiveness of the cerebral vascu-lature following prolonged ischemia in cat brain. Stroke 8: 707–712, 1977.
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© 1980 Plenum Press, New York
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Fischer, E.G. (1980). Alterations in Cerebral Blood Flow Immediately after Brief Periods of Stasis. In: Eisenberg, H.M., Suddith, R.L. (eds) The Cerebral Microvasculature. Advances in Experimental Medicine and Biology, vol 131. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3752-2_21
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DOI: https://doi.org/10.1007/978-1-4684-3752-2_21
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