Abstract
Abnormalities of the cerebral circulation are frequently seen in patients with head injury, as well as in animals subjected to experimental brain injury (1). Despite considerable interest in the mechanisms underlying these abnormalities, no comprehensive hypothesis has been advanced to explain their pathogenesis. The practical value of a fuller understanding of the mechanisms responsible for abnormal circulatory function in brain injury is high because it may lead to more rational, therapeutic intervention.
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References
Langfitt TW, Weinstein JD, Kassell NF: Vascular factors in head injury. In, Caveness WF, Walker AE (eds): Head Injury, Philadelphia, J.B. Lippincott Co, 1966, pp 172–194.
Levasseur JE, Wei EP, Raper AJ, et al: Detailed description of a cranial window technique for acute and chronic experiments. Stroke 6: 308–317, 1975.
Lindgren S, Rinder L: Production and distribution of intracranial and intraspinal pressure changes at sudden extradural fluid volume input in rabbits. Acta Physiol y Scand 76: 340–351, 1969.
Sullivan HG, Martinez J, Becker DP, et al: Fluid-percussion model of mechanical brain injury in the cat. J Neurosurg 45: 520–534, 1976.
Dietrich WD, Wei EP, Povlishock JT: A method for the morphophysiological study of specific pial microvessel. Am J Physiol (In Press).
Navari RM, Wei EP, Kontos HA: Oxygen consumption of pialarteries. Am J Physiol 236: H151–H156, 1979.
Kontos HA, Wei EP, Navari RM, et al: Responses of cerebral arteries and arterioles to acute hypotension and hyper-tension. Am J Physiol 234: H371 - H383, 1978.
Povlishock JT, Kontos HA, Wei EP: Changes in the cerebral vasculature after hypertension and trauma: A combined scanning and transmission electron microscopic analysis. In, Eisenberg HM and Suddith RL (eds): The Cerebral Microvasculature: Investigation of the Blood-Brain Barrier, New York, Plenum Press, 1980, pp 57–65.
Bergstrom S, Carlson LA, Weeks JR: The prostaglandins: A family of biologically active lipids. Pharmacol Rev 20: 1–37, 1968.
Eagan RW, Paxton J, Kuehl FA Jr: Mechanism for irreversible self-deactivation of prostaglandin synthetase. J Biol Chem 251: 7329–7335, 1976.
Baehner RL, Nathan DG: Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med 278: 971–976, 1968.
Fridovich I: Superoxide dismutases. Ann Rev Biochem 44: 147–159, 1975.
Beauchamp C, Fridovich I: A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem 245: 4641–4646, 1970.
Neta P, Dorfman LM: Pulse radiolysis studies. XIII. Rate constants for the reaction of hydroxyl radicals with aromatic compounds in aqueous solutions. Adv Chem Ser 81: 222–230, 1968.
Fry DL: Acute vascular endothelial changes associated with increased blood velocity gradients. Circ Res 22: 165–197, 1968.
Fry DL: Certain histological and chemical responses of the vascular interface to acutely induced mechanical stress in the aorta of the dog. Circ Res 24: 93–108, 1969.
Fry DL: Certain chemorheologic considerations regarding the blood vascular interface with particular reference to coronary artery disease. Circulation 40 (Suppl 4): 38–59, 1969.
Rittenhouse-Siimnons S, Deykin D: The mobilization of arachidonic acid in platelets exposed to thrombin or ionophore A23187. J Clin Invest 60: 495–498, 1977.
Tappel AL: Lipid peroxidation damage to cell components. Fed Proc 32: 1859–1861, 1973.
Demopoulos HB, Flamm ES, Seligman ML: Membrane perturbations in central nervous system injury: Theoretical basis for free radical damage and a review of the experimental data. In, Popp AJ: Neural Trauma, New York, Raven Press, 1979, pp 63–78.
Fong KL, McCay PB, Poyer JL: Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme-activity. J Biol Chem 248: 7792–7797, 1973.
Smith WL, Wilkin GP: Immunochemistry of prostaglandin endoperoxide-forming cyclooxygenases: The detection of the cyclooxygenases in rat, rabbit, and guinea pig kidneys by immunofluorescence. Prostaglandins 13: 873–892, 1977.
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© 1980 Plenum Press, New York
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Kontos, H.A., Dietrich, W.D., Wei, E.P., Ellis, E.F., Povlishock, J.T. (1980). Abnormalities of the Cerebral Microcirculation after Traumatic Injury: The Relationship of Hypertension and Prostaglandins. In: Eisenberg, H.M., Suddith, R.L. (eds) The Cerebral Microvasculature. Advances in Experimental Medicine and Biology, vol 131. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3752-2_19
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DOI: https://doi.org/10.1007/978-1-4684-3752-2_19
Publisher Name: Springer, Boston, MA
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