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Aging and Changes in Genetic Information

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Aging Phenomena

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 129))

Abstract

Although all placental mammals are characterized by similar morphological, physiological, and biochemical parameters, they differ from one another in maximum achievable life span by approximately fifty-fold (1,2). Even within closely associated families of recent evolutionary occurrence, such as the primates and Myomorph rodents, e.g., Mus musculus and Peromyscus leucopus, life spans vary by more than twenty fold (3) and three fold (4), respectively. Thus, it appears that whatever governs the life span of a species must be able to be modified rapidly. This imposes strong constraints on the possible genetic mechanisms for the evolution of longevity-assurance systems (4). Two ways by which rapid evolution of longevity could occur, and yet be consistent with basic molecular genetics, would be either via modification of already existing genetic information (species differences in longevity reflecting differences in the turning off of longevity-assurance systems during fetal development), or through slight but significant changes in a number of interlocking processes governing phenotypic expression. Either or both of these mechanisms might explain the rapid evolution of life span within species without necessitating the concurrent input of new genes.

This work was supported by National Cancer Institute Contract No. Nol-CB-84226.

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References

  1. A. Comfort, in:“Ageing, The Biology of Senescence,” Holt, Rinehart and Wilson, New York (1964).

    Google Scholar 

  2. W. Andrew, in:“The Fine Structure and Histochemical Changes in Ageing,” Academic Press, New York (1968).

    Google Scholar 

  3. R. G. Cutler, Exp. Gerontol. 10:37 (1975).

    Article  PubMed  CAS  Google Scholar 

  4. G. A. Sacher and R. W. Hart, in:“Genetic Effects of Aging,” D. Bergsma and D. Harrison, eds., Alan R. Liss, New York (1978).

    Google Scholar 

  5. P. Burch, in:“The Fine Structure and Histochemical Changes in Ageing,” Academic Press, New York (1968).

    Google Scholar 

  6. C. Finch, in:“Animal Models for Biomedical Research IV“, Nat. Acad. Sci. USA, Wash., D.C. (1971).

    Google Scholar 

  7. N. Shock, Ann. Rev. Physiol. 23:97 (1961).

    Article  CAS  Google Scholar 

  8. A. Engel and R. Larsson, in:“Cancer and Aging,” Norcliska Bakhandelns Forlag, Stockholm (1978).

    Google Scholar 

  9. T. Makinodan, E. Perkins, and M. Chen, Adv. Gerontol. Res. 3:171 (1971).

    PubMed  CAS  Google Scholar 

  10. A. G. Schwartz, Exp. Cell Res. 94:445 (1975).

    Article  PubMed  CAS  Google Scholar 

  11. A. G. Schwartz and C. J. Moore, Exp. Cell Res. 109:448 (1977).

    Article  PubMed  CAS  Google Scholar 

  12. E. Boyland, Biochem. Soc. Symp. 5:40 (1950).

    CAS  Google Scholar 

  13. P. Sims and P. L. Grover, Adv. Cancer Res. 20:165 (1975).

    Article  Google Scholar 

  14. M. E. Duncan and P. Brookes, Int. J. Cancer 4:813 (1970).

    Article  Google Scholar 

  15. E. Huberman, J. K. Selkirk, and C. Heidelberger, Cancer Res. 31:2161 (1971).

    PubMed  CAS  Google Scholar 

  16. M. E. Duncan and P. Brookes, Int. J. Cancer 9:349 (1972).

    Article  PubMed  CAS  Google Scholar 

  17. A. H. Conney, Science 178:576 (1972).

    Article  PubMed  CAS  Google Scholar 

  18. H. V. Gelboin, F. J. Weibel, and H. Kinoshita, in:“Chemical Carcinogenesis,” P. O. P. T’so and J. A. DiPaolo, eds., Marcel Dekker, New York (1974).

    Google Scholar 

  19. D. W. Nebert and H. V. Gelboin, Arch. Biochem. Biophys. 134:76 (1969).

    Article  PubMed  CAS  Google Scholar 

  20. G. Kellerman, E. Cantrell, C. R. Shaw, Cancer Res. 33:1654 (1973).

    Google Scholar 

  21. J. P. Whitlock and H. V. Gelboin, J. Radiol. Chem. 249: 2616 (1974).

    CAS  Google Scholar 

  22. J. P. Whitlock, and H. V. Gelboin, J. Biol. Chem. 248:6114 (1973).

    PubMed  Google Scholar 

  23. D. W. Nebert, W. F. Benedict, J. E. Gielen, F. Oesch, and J. W. Daly, Mol. Pharmacol. 8:374 (1972).

    PubMed  CAS  Google Scholar 

  24. R. E. Kouri, H. Ratrie, and C. E. Whitmore, J. Natl, Cancer Inst. 51:197 (1973).

    CAS  Google Scholar 

  25. F. J. Weibel, J. C. Leutz, and H. V. Belboin, Arch. Biochem. Biophys. 154:292 (1973).

    Article  Google Scholar 

  26. K. Burki, A. G. Liebelt, and E. Bresnick, J. Natl. Cancer Inst. 50:369 (1973).

    PubMed  CAS  Google Scholar 

  27. G. Kellerman, C. R. Shaw, M. Lugten-Kellerman, N. Engl. J. Med. 289:934 (1973).

    Article  Google Scholar 

  28. A. Comfort, in:“Ageing, the Biology of Senescence,” Holt, Rinehart and Wilson, New York (1964).

    Google Scholar 

  29. R. W. Hart, and R. B. Setlow, Proc. Natl. Acad. Sci. USA 71:2169 (1974).

    Article  PubMed  CAS  Google Scholar 

  30. D. E. Brash and R. W. Hart, J. Environ. Pathol. Toxicol. 2:79 (1978).

    PubMed  CAS  Google Scholar 

  31. H. F. Stich and R. H. C. San, Proc. Soc. Exp. Biol. Med. 142:155 (1973).

    PubMed  CAS  Google Scholar 

  32. J. E. Cleaver, in:“Methods in Cancer Research,” vol. 9, H. Busch, ed., Academic Press, New York (1975).

    Google Scholar 

  33. R. W. Hart and J. E. Trosko, Interdisc. Top. Gerontol. 9:134 (1976).

    CAS  Google Scholar 

  34. J. E. Cleaver and J. E. Trosko, Photochem. Photobiol. 11:547 (1970).

    Article  PubMed  CAS  Google Scholar 

  35. J. E. Cleaver, Nature 270:451 (1977).

    Article  PubMed  CAS  Google Scholar 

  36. R. B. Setlow, J. D. Regan, and W. L. Carrier, Biophys. Soc. Abstr. 12:19a (1972).

    Google Scholar 

  37. K. Hall, C. Albrightson, and R. W. Hart, XIth Internat. Cong. Gerontol., Tokyo, Japan (1978).

    Google Scholar 

  38. V. Paffenholz, Mech. Ageing Dev. 7:131 (1978).

    Article  PubMed  CAS  Google Scholar 

  39. P. Cerutti, K. Shinohara, and J. Remsen, J. Toxicol. Environ. Health 2:1375 (1977).

    Article  PubMed  CAS  Google Scholar 

  40. J. Smith-Sonneborn, personal communications (1978).

    Google Scholar 

  41. A. Dipple and J. J. Roberts, Biochemistry 16:1499 (1977).

    Article  PubMed  CAS  Google Scholar 

  42. M. Ikenaga, Y. Ishii, M. Toda, T. Kakunaga, H. Takebe, and S. Kondo, in:“Molecular Mechanisms for Repair of DNA,” P. C. Hanawalt and R. B. Setlow, eds., Plenum Press, New York (1975).

    Google Scholar 

  43. R. Ben-Ishai, and I. Peleg, in: “Molecular Mechanisms for Repair of DNA, P. C. Hanwalt and R. B. Setlow, Plenum Press, New York (1975).

    Google Scholar 

  44. R. W. Hart, S. D’Ambrosio, K. J. Ng, and S. P. Modak, Mech. Ageing Dev. 9:203 (1978).

    Article  Google Scholar 

  45. R. W. Hart, K. Y. Hall, and F. B. Daniel, Photochem. Photobiol. 28:131 (1978).

    Article  PubMed  CAS  Google Scholar 

  46. S. P. Modak and F. J. Bollum, Exp. Cell Res. 62:421 (1970).

    Article  PubMed  CAS  Google Scholar 

  47. S. P. Modak and F. J. Bollum, Exp. Cell Res. 75:307 (1972).

    Article  PubMed  CAS  Google Scholar 

  48. S. P. Modak and G. B. Price, Exp. Cell Res. 65:289 (1971).

    Article  PubMed  CAS  Google Scholar 

  49. G. B. Price, S. P. Modak, and T. Makinodan, Science 190:917 (1971).

    Article  Google Scholar 

  50. H. R. Massie, M. B. Baird, and R. J. Nicolosi, Arch. Biochem. Biophys. 153:736 (1972).

    Article  PubMed  CAS  Google Scholar 

  51. S. P. Modak, in:“Cell Differentiation,” R. Harris, P. Allen, and D. Viza, eds., Munksgaard Publications, Copenhagen (1972).

    Google Scholar 

  52. S. P. Modak and H. Traurig, Cell Differentiation 1:351 (1972).

    Article  PubMed  CAS  Google Scholar 

  53. J. Piatigorsky, S. S. Rothschild, and L. M. Milstone, Dev. Biol. 34:334 (1973).

    Article  PubMed  CAS  Google Scholar 

  54. P. Karran and M. G. Ormerod, Biochim. Biophys. Acta 299:54 (1973).

    PubMed  CAS  Google Scholar 

  55. K. J. Wheeler and J. T. Lett, Proc. Natl. Acad. Sci. USA 71:1962 (1974).

    Article  Google Scholar 

  56. M. F. Counis, E. Chaudun, and Y. Courtois, Dev. Biol. 57:47 (1977).

    Article  PubMed  CAS  Google Scholar 

  57. D. W. Appleby and S. P. Modak, Proc. Natl. Acad. Sci. USA 74:5579 (1977).

    Article  PubMed  CAS  Google Scholar 

  58. S. Goldstein, N. Engl. J. Med. 285:1120 (1971).

    Article  PubMed  CAS  Google Scholar 

  59. G. M. Hahn, D. King, and S. J. Yang, Nature 230:242 (1971).

    Article  CAS  Google Scholar 

  60. F. E. Stockdale, Science 171:1145 (1971).

    Article  PubMed  CAS  Google Scholar 

  61. F. E. Stockdale and M. C. O’Neil, J. Cell Biol. 52:589 (1972).

    Article  PubMed  CAS  Google Scholar 

  62. R. W. Hart and R. B. Setlow, Mech. Ageing Dev. 5:67 (1976).

    Article  PubMed  CAS  Google Scholar 

  63. M. R. Mattern and P. Cerutti, Biochim. Biophys. Acta 395:48 (1975).

    PubMed  CAS  Google Scholar 

  64. G. E. Milo and R. W. Hart, Arch. Biochem. Biophys. 176:324 (1976).

    Article  PubMed  CAS  Google Scholar 

  65. A. C. Chen, S. K. C. Ng, and I. G. Walker, J. Cell Biol. 70:685 (1976).

    Article  Google Scholar 

  66. J. Treton, S. P. Modak, and Y. Courtois, manuscript in preparation (1978).

    Google Scholar 

  67. A. Ruiz-Carilio, L. J. Wangh, and V. G. Allfrey, Science 190:117 (1975).

    Article  Google Scholar 

  68. A. Olins and D. E. Olins, Science 183:330 (1974).

    Article  PubMed  CAS  Google Scholar 

  69. P. Oudet, M. Gross-Bellard, and P. Chambon, Cell 4:281 (1975).

    Article  PubMed  CAS  Google Scholar 

  70. D. R. Hewish and L. A. Burgoyne, Biochem. Biophys. Res. Comm. 52:504 (1973).

    Article  PubMed  CAS  Google Scholar 

  71. M. Noll, Nature 251:249 (1974).

    Article  PubMed  CAS  Google Scholar 

  72. E. M. Bradbury, in:“The Organization of Expression of Ekaryotic Genome,” E. M. Bradbury and K. Javaherian, eds., Academic Press, New York (1977).

    Google Scholar 

  73. R. D. Kornberg, Science 184:868 (1974).

    Article  PubMed  CAS  Google Scholar 

  74. R. D. Kornberg and J. O. Thomas, Science 184:865 (1974).

    Article  PubMed  CAS  Google Scholar 

  75. B. Sollner-Webb and G. Felsenfeld, Biochemistry 14:2915 (1975).

    Article  PubMed  CAS  Google Scholar 

  76. R. Axel, H. Cedar, and G. Felsenfeld, Proc. Natl. Acad. Sci. USA 70:2921 (1975).

    Google Scholar 

  77. J. O. Thomas, in:“The Organization and Expression of Eukaryotic Genome,” E. M. Bradbury and K. Javaherian, eds. Academic Press, New York (1977).

    Google Scholar 

  78. N. R. Morris, Cell 9:627 (1976).

    Article  PubMed  CAS  Google Scholar 

  79. B. R. Shaw, T. M. Herman, R. T. Kovacic, G. S. Beaudreau, and K. E. van Holde, Proc. Natl. Acad. Sci. USA 73:505 (1976).

    Article  PubMed  CAS  Google Scholar 

  80. A. J. Varshavsky, V. V. Bakayev, and G. P. Georgiev, Nucleic Acids Res. 3:477 (1976).

    PubMed  CAS  Google Scholar 

  81. J. P. Whitlock and R. T. Simpson, Biochemistry 15:3307 (1976).

    Article  PubMed  CAS  Google Scholar 

  82. R. J. Wilkins and R. W. Hart, Nature 247:35 (1976).

    Article  Google Scholar 

  83. W. J. Bodell, Nucleic Acids Res. 4:2619 (1977).

    Article  PubMed  CAS  Google Scholar 

  84. W. Andrew, in:“The Fine Structure and Histochemical Changes in Ageing,” Academic Press, New York (1968).

    Google Scholar 

  85. H. Weintraub, A. Worcel, and B. Alberts, Cell 9:409 (1978).

    Article  Google Scholar 

  86. A. Garel and R. Axel, Proc. Natl. Acad. Sci. USA 73:3966 (1976).

    Article  PubMed  CAS  Google Scholar 

  87. H. Weintraub and M. Groudine, Science 193:848 (1976).

    Article  PubMed  CAS  Google Scholar 

  88. M. J. Pythilla and F. G. Sherman, Biochem. Biophys. Res. Comm. 31:340 (1968).

    Article  Google Scholar 

  89. D. I. Kurtz and F. M. Sinex, Biochim. Biophys. Acta 145:840 (1967).

    PubMed  CAS  Google Scholar 

  90. H. P. von Hahn, Gerontologia 16:116 (1970).

    Article  Google Scholar 

  91. S. M. Zhelabovskaya and G. D. Berdyshev, Exp. Gerontol. 7:313 (1972).

    Article  PubMed  CAS  Google Scholar 

  92. D. I. Kurtz, A. P. Russel, and F. M. Sinex, Mech. Ageing Dev. 3:37 (1974).

    Article  PubMed  CAS  Google Scholar 

  93. H. Y. Samis and V. J. Wulff, Exp. Gerontol. 4:111 (1969).

    Article  PubMed  CAS  Google Scholar 

  94. B. T. Hill, Gerontologia 22:111 (1976).

    Article  CAS  Google Scholar 

  95. R. G. Cutler, Proc. Natl. Acad. Sci. USA 72:4664 (1975).

    Article  PubMed  CAS  Google Scholar 

  96. Zh. A. Medvedev, M. N. Medvedeva, and L. I. Huschtscha Gerontology 23:334 (1977).

    Article  PubMed  CAS  Google Scholar 

  97. Zh. A. Medvedev, M. N. Medvedeva, and L. Robson, Gerontology 24:286 (1978).

    Article  PubMed  CAS  Google Scholar 

  98. T. Lindahl and S. Ljungquist, in:“Molecular Mechanisms for Repair of DNA,” P. C. Hanawalt and R. B. Setlow, eds., Plenum Press, New York (1975).

    Google Scholar 

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Authors and Affiliations

  1. Pharmacology and Preventive Medicine, The Ohio State University College of Medicine, 410 W. 10th Ave., Columbus, Ohio, 43210, USA

    R. W. Hart (Professor of Radiology)

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  1. R. W. Hart
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  2. S. P. Modak
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Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    Kunio Oota  & Masami Iriki  & 

  2. Veterans Administration, Wadsworth Medical Center, Los Angeles, California, USA

    Takashi Makinodan  & Lynn S. Baker  & 

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© 1980 Plenum Press, New York

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Hart, R.W., Modak, S.P. (1980). Aging and Changes in Genetic Information. In: Oota, K., Iriki, M., Makinodan, T., Baker, L.S. (eds) Aging Phenomena. Advances in Experimental Medicine and Biology, vol 129. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3734-8_12

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  • DOI: https://doi.org/10.1007/978-1-4684-3734-8_12

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