Abstract
Multicellular organisms are equipped with an intricate system to recognize and neutralize foreign and potentially dangerous components such as parasites, microorganisms, and neoplastic cells. However, many neoplastic tissues are capable of proliferative growth eventually leading to the death of the host, despite potential host antitumor cellular and humoral immunity. Inefficient antitumor activity is probably due to a complex series of events and factors that may include malfunction or suppression of host cells involved in antitumor responses and/or modification of tumor cells, for example, nonexpression or modification of antigenic determinants, inhibition of potential antitumor responses by antigen, sera, and/or tumor cell membrane complexes, accessibility of the tumor to components of the immune system, and a rate of tumor growth that outstrips the responses generated against it. An understanding of the characteristics, functions, and interactions of humoral and cellular host components involved in such responses might enable manipulation to benefit the individual.
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Berke, G., Schick, B. (1980). Tumor Immunity in the Peritoneal Cavity. In: Witz, I.P., Hanna, M.G. (eds) In Situ Expression of Tumor Immunity. Contemporary Topics in Immunobiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3677-8_14
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