Abstract
Pathologists have been aware for decades that malignant tumors can become infiltrated with significant numbers of nonmalignant stromal and lymphoreticular host cells. For certain types of malignancies, e.g., breast carcinoma, it has been claimed that the prognosis may correlate with the extent of host cell infiltration (reviewed by Underwood, 1974, and Ioachim, 1976). However, it is obvious that the light microscope has certain serious limitations when it comes to screening neoplasms for host cells. It cannot, for example, discriminate between a T or a B lymphocyte, nor can it be used as a reliable tool, as Alexander has stressed (1975), to detect certain kinds of host cells, in particular, macrophages. This fact, combined with the increasing awareness of the existence of functional subclasses of lymphocytes and macrophages (e.g., helper, killer, and suppressor T-cell subclasses), has made quantitative and qualitative studies of host cell infiltration an important feature of current tumor biology research.
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References
Alexander, P., 1975, The role of macrophages in the host defense cancer, in: Host Defense against Cancer and its Potentiation ( D. Mizuno, ed.), pp. 113–123, University of Tokyo Press, Tokyo.
Baker, R. M., and Ling, V., 1978, Membrane mutants of mammalian cells in culture, Methods Membrane Biol. 9: 337–384.
Bayreuther, K., and Klein, E., 1958, Cytogenetic, serologic, and transplantation studies on a heterozygous tumor and its derived variant sublines, J. Natl. Cancer Inst. 21: 885–923.
Birbeck, M. S. C., and Carter, R. L., 1972, Observations on the ultrastructure of two hamster lymphomas with particular reference to infiltrating macrophases, Int. J. Cancer 9: 249–257.
Bjaring, B., and Klein, G., 1968, Antigenic characterization of heterozygous mouse lymphomas after immunoselection in vivo, J. Natl. Cancer Inst. 4: 1411–1429.
Davidson, W. F., and Parish, C. R., 1975, A procedure for removing red cells and dead cells from lymphoid cell suspensions, J. Immunol. Methods 7: 291–300.
Eccles, S., and Alexander, P., 1974, Macrophage content of tumors in relation to metastatic spread and host immune reaction, Nature (London) 250: 667–669.
Fidler, I. J., 1973, Selection of successive tumor lines for metastasis, Nature (London) 242: 148–149.
Fidler, I. J., and Kripkie, M., 1977, Metastasis results from pre-existing variant cells within a malignant tumor, Science 197: 898–895.
Gershon, R. K., Carter, R. L., and Lane, N. J., 1967, Studies on homotransplantable lymphomas in hamsters, Am. J. Pathol. 51: 1111–1113.
Graham, S. D., Mickey, D. P., and Paulson, D. F., 1978, Detection of metastatic tumors in nude mice, J. Natl. Cancer Inst. 60: 715–716.
Haskill, J. S., Yamamura, Y., and Radov, L., 1975, Host responses within solid tumors: Nonthymus-derived specific cytotoxic cells within a murine mammary adenocarcinoma, Int. J. Cancer 16: 798–809.
Husby, G., Hoagland, P. M., Strickland, R. C., and Williams, R. C., 1976, Tissue T and B cell infiltration of primary and metastatic cancer, J. Clin. Invest. 3: 465–475.
Ioachim, H. L., 1976, The stromal reaction of tumors: An expression of immune surveillance, J. Natl. Cancer Inst. 3: 465–475.
Kerbel, R. S., 1980, Immunologic studies of membrane mutants of a highly metastic murine tumor, Am. J. Pathol. 97: 609–622.
Kerbel, R. S., and Davies, A. J. S., 1974, The possible biological significance of Fc receptors in mammalian cells lymphocytes and tumor cells, Cell 3: 105–112.
Kerbel, R. S., and Pross, H. F., 1976, Fc receptor-bearing cells as a reliable marker for quantitation of host lymphoreticular infiltration of progressively growing solid tumors, Int. J. Cancer 18: 432–438.
Kerbel, R. S., Pross, H. F., and Elliott, E. V., 1975, Origin and partial characterization of Fc receptor-bearing cells found within experimental carcinomas and sarcomas, Int. J. Cancer 15: 918–932.
Kerbel, R. S., Pross, H. F., and Liebovitz, A., 1977, Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors, Int. J. Cancer 20: 673–679.
Kerbel, R. S., Twiddy, R. R., and Robertson, D. M., 1978, Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low-metastatic H-2 heterozygous tumor cell line into an H-2 incompatible parental strain, Int. J. Cancer 22: 583–594.
Kerbel, R. S., Florian, M., Man, M. S., Dennis, J., and McKenzie, I. F. C., 1980, On the carcinogenicity of tumor cell populations: Studies on the origin of a putative H-2 isoantigenic loss variant tumor, J. Natl. Cancer Inst. 64.
Klein, J., 1975, Biology of the Mouse Histocompatability-2 Complex, Springer-Verlag, New York.
Klein, G., Sjögren, H. O., Klein, E., and Hellström, K. E., 1960, Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host, Cancer Res. 20: 1561–1572.
Koller, P. C., 1972, The role of chromosomes in cancer biology, in: Recent Results in Cancer Research, pp. 89–96, Springer-Verlag, New York.
Mankovitz, R., Buchwald, M., and Baker, R. M., 1974, Isolation of ouabain-resistant human diploid fibroblasts, Cell 3: 221–226.
Mantovani, A., 1978, Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity, Int. J. Cancer 22: 741–746.
Mellgren, J., 1976, Quantitation of metastases in experimental animals, in: Fundamental Aspects of Metastasis ( L. Weiss, ed.), pp. 243–252, Elsevier-North Holland, New York.
Moore, K., and Moore, M., 1977, Intra-tumor host cells of transplanted rat neoplasms of different immunogenicity, Int. J. Cancer 19: 803–813.
Nagy, Z., Elliott, B. E., and Nabholz, M., 1976, Specific binding of K- and I- region products of the H-2 complex to activated thymus-derived (T) cells belonging to different Ly subclasses, J. Exp. Med. 144: 1545–1553.
Pasqualini, C. D., Saal, F., Braylan, R. C., and Rabasa, S. L., 1970, Induction of leukemia in BALB/c mice by allogeneic AKR leukemic cells, Int. J. Cancer 5: 338–345.
Pross, H. F., and Kerbel, R. S., 1976, An assessment of intratumor phagocytic and surface marker-bearing cells in a series of autochthonous and early passaged chemically induced murine sarcomas, J. Natl. Cancer Inst. 57: 1157–1167.
Rajan, R. V., and Flores, C., 1977, H-2 antigen variants in a cultured heterozygous mouse leukemia cell line. III. Effect of selection against a D-end gene, Immunogenetics 5: 585–596.
Sugarbaker, E. V., Thornthwaite, T., and Ketcham, A. S., 1977, Inhibitory effect of a primary tumor on metastasis, in: Cancer Invasion and Metastasis: Biologic Mechanisms and Therapy ( S. B. Day, W. P. L. Meyers, P. Stansly, S. Garattini, and M. G. Lewis, eds.), pp. 227–241, Raven Press, New York.
Tao, T. W., and Burger, M. M., 1977, Non-metastasizing variants selected from metastasizing melanoma cells, Nature (London) 270: 437–438.
Underwood, J. C. E., 1974, Lymphoreticular infiltration in human tumors: Prognostic and biological implications: A review, Br. J. Cancer 30: 353–547.
Wood, G. W., and Gillespie, G. Y., 1975, Studies on the role of macrophages in regulation of growth and metastasis of murine chemically induced fibrosarcomas, Int. J. Cancer 16: 1022–1029.
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Kerbel, R.S., Twiddy, R.R., Frost, P. (1980). Host Cell Analysis of a Rapidly Metastasizing Mouse Tumor and Derived Low-Metastatic Variant Lines. In: Witz, I.P., Hanna, M.G. (eds) In Situ Expression of Tumor Immunity. Contemporary Topics in Immunobiology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3677-8_11
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DOI: https://doi.org/10.1007/978-1-4684-3677-8_11
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