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Neuroamine Condensations in Human Subjects

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Biological Effects of Alcohol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 126))

Abstract

Non-enzymatic reactions have held relatively little appeal for biomedical researchers who work with mammalian tissues and eucharyotic cells, and understandably so. When confronted with the splendid array and catalytic efficiencies of enzymes, it can be argued that “uncatalyzed” reactions should be rare in occurrence and probably minor in significance. Accumulated studies indicate however, that presumably non-enzymatic reactions — in particular, bimolecular condensations between amino compounds and aldehydes or α-keto acids — are not as uncommon as assumed. In part, this revelation is due to the new and highly sensitive chromatography methods which have developed recently (Collins, 1977). And other studies, neuropharmacological, enzymological, and behavioral in nature, demonstrate that certain condensation “products” are clearly not insignificant or innocuous agents.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Loyola University Stritch School of Medicine, Maywood, IL, 60153, USA

    Michael A. Collins

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  1. Michael A. Collins
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Editors and Affiliations

  1. Downstate Medical Center, Brooklyn, New York, USA

    Henri Begleiter

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© 1980 Plenum Press, New York

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Collins, M.A. (1980). Neuroamine Condensations in Human Subjects. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3632-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3634-1

  • Online ISBN: 978-1-4684-3632-7

  • eBook Packages: Springer Book Archive

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