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A New Model for Reducing Ethanol Toxicity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 126))

Abstract

As early as 1933, Widmark (Widmark, 1933) reported that when either glycine or alanine was co-administered with ethanol, lowered blood ethanol levels resulted as compared to those achieved when ethanol was administered. (The subjects used were dogs.) He concluded that a stable compound was formed between ethanol and the amino acids and that this accounted for decreased appearance of ethanol in the blood.

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References

  1. Coppen, A. et al. 1967. Tryptophan In the treatment of depression. Lancet. 2:1178.

    Article  CAS  PubMed  Google Scholar 

  2. Dorato, M.A. et al. 1977. Effect of Lysine on Acute Toxicity of Ethanol in Mice. J. Pharm. Sci. 66:35.

    Article  CAS  PubMed  Google Scholar 

  3. Dorato, M.A. and Ward. C.O. 1978. Unpublished data. Personal Communication.

    Google Scholar 

  4. Elbel, H. & Schleyer F., 1956. Blutalkohol. 2nd Ed. Georg Thieme, Stuttgart.

    Google Scholar 

  5. Forney, R.B. et al 1963. Toxicity and depressant action of ethanol and hexobarbltal after pre-treatment with asparaglne. Toxicol. Appl. Pharmacol. 5:790.

    Article  CAS  PubMed  Google Scholar 

  6. Jarowski, C. & Ward, C.O., 1971. Effect of Tryptophan on Toxicity and Depressant Effects of Barbiturates and Ethanol In Rats. Tox and Appl. Pharmacol. 18:603.

    Article  CAS  Google Scholar 

  7. Jarowski, C., 1964. U.S. Patent 3,080,234.

    Google Scholar 

  8. Kalant, H., 1970. Effects on Biological Membranes (in) The Biology of Alcoholism ed. by B. Klssln and H. Begleiter. Plenum, New York. p40ff.

    Google Scholar 

  9. Krebs, S. & Lynch, V.de P., 1978. A Potential New Model for the Study of the Effects of Alcohol on the Rat. Fed. Proc. 37(3):246.

    Google Scholar 

  10. Orten, J.M. & Sardesal, V.M. Protein, Nucleotide and Porphyrin Metabolism. (In) The Biology of Alcoholism, ed. by B. Kissin and H. Begleiter. Plenum, New York, p.229ff.

    Google Scholar 

  11. Smith, M.E. & Newman, H.W., 1959. Ethanol Metabolism In Fed and Fasting Animals. J. Biol. Chem. 234:1544.

    Google Scholar 

  12. Torre, G. et al. l978. Unpublished data. This Laboratory.

    Google Scholar 

  13. Ward, C.O. et al 1972. Effect of Lysine on Toxicity and Depressant Effects of Ethanol In Rats. Tox. and Appl. Pharmacol. 22:422.

    Article  CAS  Google Scholar 

  14. Widmark, E., 1933. Der EInfluss der Nahrungsbestandteile auf den Alkoholgehalt des Blutes, Biochem. Z. 267:135.

    CAS  Google Scholar 

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© 1980 Plenum Press, New York

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de Lynch, V.P., Krebs, S.J., Dorato, M.A. (1980). A New Model for Reducing Ethanol Toxicity. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_39

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  • DOI: https://doi.org/10.1007/978-1-4684-3632-7_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3634-1

  • Online ISBN: 978-1-4684-3632-7

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