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Acetaldehyde: A Positive Reinforcer Mediating Ethanol Consumption

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Biological Effects of Alcohol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 126))

Abstract

Increased interest has developed in recent years in the biochemical pharmacology of acetaldehyde, the oxidation product of ethanol, and in the role it may play in ethanol intoxication and the development of tolerance to and physical dependence on ethanol (Rahwan, 1974, 1975; Truitt and Walsh, 1971). However, little attention has been directed towards the possibility that acetaldehyde may play a role in the voluntary consumption of ethanol.

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References

  • Akabane, J. Aldehydes and related compounds. International Encyclopedia of Pharmacology and Therapeutics, 1970, 2 523–560.

    Article  Google Scholar 

  • Amir, S. Brain and liver aldehyde dehydrogenase: Relation to ethanol intake in the Wistar rat. Neuropharmacology, 1977, 16 781–784.

    Article  CAS  PubMed  Google Scholar 

  • Amir, S. Brain and liver aldehyde dehydrogenase activity and voluntary ethanol consumption by rats: Relations to strain, sex and age. Psychopharmacology, 1978a, 57, 97–102.

    Article  CAS  PubMed  Google Scholar 

  • Amir, S. Brain aldehyde dehydrogenase: Adaptive increase following prolonged ethanol administration. Neuropharmacology, 3.1978b, 17, 463–467.

    Article  CAS  PubMed  Google Scholar 

  • Amir, S. and Stern, M.H. Electrical stimulation and lesions of the medial forebrain bundle of the rat: Changes in voluntary ethanol consumption and brain aldehyde dehydrogenase activity. Psychopharmacology, 1978, 57, 167–174.

    Article  CAS  PubMed  Google Scholar 

  • Amit, Z. and Stern, M.H. A further investigation of alcohol preference in the laboratory rat induced by hypothalamic stimulation. Psychopharmacologia, 1971, 21, 317–327.

    Article  CAS  PubMed  Google Scholar 

  • Amit, Z. and Stern, M.H. Electrochemical interactions in the medial forebrain bundle and alcohol dependence in the laboratory rat. In O. Forsander and E.K. Eriksson (Eds.), Biological Aspects of Alcoholism. Finnish Foundation for Alcohol Studies, 1972, 225–231, Helsinki.

    Google Scholar 

  • Amit, Z. Brown, Z.W. Levitan, D.E. and Ogren, S.-O. Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition. Archives Internationales de Pharmacodynamie et de Therapie, 1977a, 230, 65–75.

    CAS  PubMed  Google Scholar 

  • Amit Z. Meade R.G., Levitan D.E. and Singer J. Effects of dorsal and ventral lateral hypothalamic lesions on voluntary alcohol consumption in rats. Journal of Studies on Alcohol, 1976b, 37 1188–1196.

    PubMed  Google Scholar 

  • Brown, Z.W., Amit, Z., Levitan, D.E., Ogren, S.-O., and Sutherland, E.A. Noradrenergic mediation of the positive reinforcing properties of ethanol: II. Extinction of ethanol-drinking behavior in laboratory rats by inhibition of dopamine-beta-hydroxylase. Implications for treatment procedures in human alcoholics. Archives Internationales de Pharmacodynamie et de Therapie, 1977, 230, 76–82.

    CAS  PubMed  Google Scholar 

  • Brown, Z.W., and Amit, Z. The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats. Neuroscience Letters, 1977, 5 333–336.

    Article  CAS  PubMed  Google Scholar 

  • Consbruch, U., and Derwart, A. Clinical experiences and biochemical aspects in the treatment of alcoholism with calcium carbomide. International Pharmacopsychiatry, 1968, 1,143–157

    Google Scholar 

  • Davis W.M., Smith S.G., and Werner T.E. Noradrenergic role in the self-administration of alcohol by rats. Paper presented at the Annual Meeting of the Society for Neurosciences, Anaheim, California, Nov. 6–10, 1977.

    Google Scholar 

  • Duritz, G., and Truitt, E.B., Jr. Importance of acetaldehyde in the action of ethanol on brain norepinephrine and 5-hydroxytryptamine. Biochemical Pharmacology, 1966, 15, 711–721.

    Article  CAS  PubMed  Google Scholar 

  • Eriksson, C.J.P. Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference. Biochemical Pharmacology, 1973, 22 2283–2292.

    Article  CAS  PubMed  Google Scholar 

  • Eriksson, C.J.P., and Sippel, H.W. The distribution and metabolism of acetaldehyde in rats during ethanol oxidation. I. The distribution of acetaldehyde in liver, brain, blood and breath. Biochemical Pharmacology, 1977, 26, 241–247.

    Article  CAS  PubMed  Google Scholar 

  • Garcia, J., and Koelling, R.A. Relation of cue to consequence in avoidance learning. Psychonomic Science, 1966, 4, 123–124.

    Google Scholar 

  • German, D.C., and Bowden, D.M. Catecholamine systems as the neural substrate for intracranial self-stimulation: A hypothesis. Brain Research, 1974, 73 381–419.

    Article  CAS  PubMed  Google Scholar 

  • Haid, J., and Jacobsen, E. A drug sensitizing the organism to ethyl alcohol. Lancet, 1948, 2, 1001.

    Google Scholar 

  • Hawkins, R.D., and Kalant, H. The metabolism of ethanol and its metabolic effects. Pharmacological Review, 1972, 24, 67–157.

    CAS  Google Scholar 

  • Kiessling, K.-H. The effect of acetaldehyde on rat brain mitochondria and its occurrence in brain after alcohol injection. Experimental Cell Research, 1962a, 26, 432–434.

    Article  CAS  PubMed  Google Scholar 

  • Kiessling, K.-H. The occurrence of acetaldehyde in various parts of the rat brain after alcohol injection and its effect on pyruvate oxidation. Experimental Cell Research, 1962b, 27 267–268.

    Article  Google Scholar 

  • Koivula, T., Koivusalo, M., and Lindros, K.O. Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference. Biochemical Pharmacology, 1975, 24 1807–1811.

    Article  CAS  PubMed  Google Scholar 

  • Lester, D., Nachman, M. and LeMagnen, J. Aversive conditioning by ethanol in the rat. Quarterly Journal for Studies on Alcohol, 1970, 31 578–586.

    CAS  Google Scholar 

  • Lindvall, O., and Bjorklund, A. The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid flourescence method. Acta Physiologica Scandinavica, Supplementum, 1974, 412, 1–48.

    CAS  Google Scholar 

  • Marselos, M., and Pietikainen, S. Voluntary consumption of ethanol in rats after induction of the soluble aldehyde dehydrogenase in the liver. In J.D. Sinclair and K. Kiianmaa, (Eds.), The Effects of Centrally Active Drugs on Voluntary Alcohol Consumption. The Finnish Foundation for Alcohol Studies, 24, Helsinki, 1975.

    Google Scholar 

  • Marselos, M., Eriksson, K., and Hanninen, O. Aldehyde dehydrogenase inducibility and ethanol preference in rats. Medical Biology, 1975, 53 224–230.

    CAS  PubMed  Google Scholar 

  • Myers, R.D. Alcohol consumption in rats: Effects of intracranial injections of ethanol. Science, 1963, 142, 240–241.

    Article  CAS  PubMed  Google Scholar 

  • Myers, R.D., and Melchior, C.L. Alcohol drinking: abnormal intake caused by tetrahydropopaveroline (THP) in brain. Science, 1977a, 196, 554–556

    Article  CAS  PubMed  Google Scholar 

  • Myers, R.D., and Melchior, C.L. Differential actions on voluntary alcohol intake of tetrahydroisoquinolines or a B-carb- oline infused chronically in the ventricle of the rat. Pharmacology Biochemistry and Behavior, 1977b, 7, 381–392.

    Article  CAS  Google Scholar 

  • Myers, R.D., and Veale, W.L. Alterations in volitional alcohol intake produced in rats by chronic intraventricular infusions of acetaldehyde, paraldehyde or methanol. Archives Internationales de Pharmacodynamie et de Therapie, 1969, 180, 100–113.

    CAS  PubMed  Google Scholar 

  • Myers, R.D., Veale, W.L., and Yaksh, T.L. Preference for ethanol in the Rhesus monkey following chronic infusion of ethanol into the cerebral ventricles. Physiology and Behavior, 1972, 142, 431–435.

    Article  Google Scholar 

  • Ortiz, A., Griffiths, P.J., and Littleton, J.M. A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence. Journal of Pharmacy and Pharmacology, 1974, 26, 249–260.

    Article  CAS  PubMed  Google Scholar 

  • Perman, E.S. The effect of acetaldehyde on the secretion of adrenaline and noradrenaline from the suprarenal gland of the cat. Acta Physiologica Scandinavica, 1958, 43, 71–76.

    Article  CAS  PubMed  Google Scholar 

  • Petterson, H., and Kiessling, K.H. Acetaldehyde occurrence in cerebrospinal fluid during ethanol oxidation in rats and its dependence on blood level and on dietary factors. Biochemical Pharmacology, 1977, 26, 237–240.

    Article  Google Scholar 

  • Rahwan, R.G. Speculations on the biochemical pharmacology of ethanol. Life Sciences, 1974, 15 617–633.

    Article  CAS  PubMed  Google Scholar 

  • Rahwan, R.G. Toxic effects of ethanol: Possible role of acetaldehyde, tetrahydroisoquinolines, and tetrahydro-B-carbolines. Toxicology and Applied Pharmacology, 1975, 34 3–27.

    Article  CAS  PubMed  Google Scholar 

  • Raskin, N.H., and Sokoloff, L. Brain alcohol dehydrogenase. Science, 1968, 162, 131–132.

    Article  CAS  PubMed  Google Scholar 

  • Raskin, N.H., and Sokoloff, L. Alcohol dehydrogenase activity in rat brain and liver. Journal of Neurochemistry, 1970, 17, 1677–1687.

    Article  CAS  PubMed  Google Scholar 

  • Ridge, J.W. The metabolism of acetaldehyde by the brain in vivo. Biochemical Journal, 1963, 88 95–100.

    CAS  PubMed  Google Scholar 

  • Schlesinger, K., Kakihana, R., and Bennett, E.L. Effects of tetra- ethylthiuromdisulfide (Antabuse) on the metabolism and consumption of ethanol in mice. Psychosomatic Medicine, 1966, 28 514–520.

    CAS  Google Scholar 

  • Sheppard, J.R., Albersheim, P., and McClearn, G.E. Enzyme activities and ethanol preference in mice. Biochemical Genetics, 1968, 2 205–212.

    Article  CAS  PubMed  Google Scholar 

  • Sheppard, J.R., Albersheim, P., and McClearn, G.E. Aldehyde dehydrogenase and ethanol preference in mice. Journal of Biological Chemistry, 1970, 245, 2876–2882.

    CAS  PubMed  Google Scholar 

  • Sippel, H.W. Non-enzymatic ethanol oxidation in biological extracts. Acta Chemica Scandinavica, 1973, 23 541–550.

    Article  Google Scholar 

  • Sippel, H.W. The acetaldehyde content in rat brain during ethanol metabolism. Journal of Neurochemistry, 1974, 23, 451–452.

    Article  CAS  PubMed  Google Scholar 

  • Tabakoff, B., Anderson, R., and Ritzmann, F. Brain acetaldehyde after ethanol administration. Biochemical Pharmacology, 1976, 25 1305–1309.

    Article  CAS  PubMed  Google Scholar 

  • Truitt, E.B. Jr. and Walsh, M.J. The role of acetaldehyde in the actions of ethanol. In B. Kissin and H. Begleiter (Eds.), The Biology of Alcoholism, (Vol. 1). New York; Plenum Press, 1971.

    Google Scholar 

  • Walsh, M.J. and Truitt, E.B. Jr. Release of 3H-norepinephrine in plasma and urine by acetaldehyde and ethanol in cats and rabbits. Federation Proceedings, 1968, 27 601.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Center For Research on Drug Dependence, Department of Psychology, Concordia University, 1455 de Maisonneuve Blvd. W., Montreal, Quebec, Canada

    Z. Amit, Z. W. Brown, G. E. Rockman, B. Smith & S. Amir

Authors
  1. Z. Amit
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  2. Z. W. Brown
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  3. G. E. Rockman
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  4. B. Smith
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  5. S. Amir
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Editor information

Editors and Affiliations

  1. Downstate Medical Center, Brooklyn, New York, USA

    Henri Begleiter

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© 1980 Plenum Press, New York

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Amit, Z., Brown, Z.W., Rockman, G.E., Smith, B., Amir, S. (1980). Acetaldehyde: A Positive Reinforcer Mediating Ethanol Consumption. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_30

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  • DOI: https://doi.org/10.1007/978-1-4684-3632-7_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3634-1

  • Online ISBN: 978-1-4684-3632-7

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