Abstract
Previously it has been shown that chronic administration of p-chlorophenylalanine (p-CPA), slowed the development of tolerance to ethanol, pentobarbital and cross-tolerance development to ethanol in rats chronically treated with pentobarbital. These findings have been extended by the following observations:
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(1)
p-CPA slowed the development of tolerance to barbital as measured by motor impairment on the moving belt test, without altering the acute response.
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(2)
p-CPA also reduced the tolerance to barbital as measured by sleeping time, in animals chronically treated with pentobarbital.
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(3)
Administration of L-tryptophan increased the rate of tolerance development to ethanol as measured by motor impairment and hypothermia.
These results further confirm and extend the generality of our observations that 5-HT may be involved in the development of tolerance and cross-tolerance to sedatives.
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Khanna, J.M., Le, A.D., Kalant, H., LeBlanc, A.E. (1980). Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_17
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