Abstract
An important question facing our society is the impact of numerous chemical insults on the health of man and his environment. Faced with a staggering array of chemicals and enormous testing costs, we can test only a few chemicals for possible carcinogenic effects. Recent results with the Salmonella/mammalian microsome mutagenesis assay developed by Ames (2), demonstrating a striking correlation between carcinogenicity and mutagenicity of many chemical compounds, offer the possibility that mutagenesis assay systems can provide a quick identification of potential carcinogens. Results from microbial assays can serve as a guideline for further mutagenesis testing as well as identify those compounds requiring more extensive analysis in mammalian systems.
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References
Agosin M, Perry AS: Microsomal mixed-function oxidases. In: The Physiology of Insecta, 2nd ed., Vol. V (Rockstein M, ed.). New York, Academic Press, 1974, pp 538–596
Ames BN, McCann J, Yamasaki E: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31:347–364, 1975
Auerbach C: The chemical production of mutations. Science 158:1141, 1967
Baars AJ, Zijlstra JA, Vogel E, Breimer DD: The occurrence of cytochrome P-350 and aryl hydrocarbon hydroxylase activity in Drosophila melanogaster microsomes, and the importance of this metabolizing capacity for the screening of carcinogenic and mutagenic properties of foreign compounds. Mutat Res 44:257–268, 1977
Casida JE: Insect microsomes and insecticide chemical oxidations. In: Microsomes and Drug Oxidations (Gillette JR, Conney AH, Cosmides GJ, Estabrook RW, Fouts JR, Mannering GJ, eds.). New York, Academic Press, 1969, pp 517–530
Epler JL, Larimer FW, Rao TK, Nix CЕ, Но Т: Energy-related pollutants in the environment: The use of short-term tests for mutagenicity in the isolation and identification of biohazards. Environ Health Per-spect, in press
Epler JL, Young JA, Hardigree AA, Rao TK, Guerin MR, Rubin IB, Ho C-h, Clark BR: Coupled analytical and biological analyses of test materials from the synthetic fuel technologies: Mutagenicity of crude oils from the Salmonella/microsomal activation systems. Mutat Res, in press
Lee WR: Chemical mutagenesis. In: The Genetics and Biology of Drosophila (Ashburner M, Novitski E, eds.). New York, Academic Press, Vol 1c, 1976, pp 1299–1341
Nix CE, Brewen B, Epler JL: Microsomal activation of selected polycyclic aromatic hydrocarbons and aromatic amines in Drosophila melanogaster. Mutat Res, in press
Vogel E, Leigh B: Concentration-effect studies with MMS, TEB, 2,4,6-TriCl-PDMT, and DEN on the induction of dominant and recessive lethals: Chromosome loss and translocation in Drosophila sperm. Mutat Res 39:383–396, 1975
Vogel E, Sobels FH: The function of Drosophila in genetic toxicology testing. In: Chemical Mutagens: Principles and Methods for Their Detection (Hollaender A, ed.). New York, Plenum Press, Vol 4, 1976, pp 93–142
Vogel E, Luers H: A comparison of adult feeding to injection in D. melanogaster. Drosophila Inform Serv 51: 113–114, 1974
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Nix, C.E., Brewen, B. (1978). The Role of Drosophila in Chemical Mutagenesis Testing. In: Waters, M.D., Nesnow, S., Huisingh, J.L., Sandhu, S.S., Claxton, L. (eds) Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures. Environmental Science Research, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3611-2_5
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DOI: https://doi.org/10.1007/978-1-4684-3611-2_5
Publisher Name: Springer, Boston, MA
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