Environmental Chemical-Induced Modification of Cell-Mediated Immune Responses

  • J. B. Silkworth
  • L. D. Loose
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Technological advancement is accompanied by the development of many new chemical compounds followed by their dispersion, both intentional and accidental, throughout the biosphere. Although originally found in the environment at low, possibly harmless levels, many compounds are concentrated by biomagnification resulting in the exposure of mammals to potentially deleterious levels of the chemical compounds (26). In addition, certain mammalian tissues including primary lymphoid organs can concentrate dietary chemicals to levels well above those ingested (22), thereby resulting in exposure to concentrations above established maximal safety limits.


Spleen Cell Stimulation Index Dietary Exposure Incorporation Rate Mixed Lymphocyte Culture 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. B. Silkworth
    • 1
  • L. D. Loose
    • 1
  1. 1.Institute of Comparative and Human ToxicologyAlbany Medical CollegeAlbanyUSA

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