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The Mononuclear Phagocyte System and Hemopoiesis

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Book cover Macrophages and Lymphocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 121B))

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Abstract

The in vitro’bone marrow culture technique developed in recent years and employed in extensive studies has demonstrated that mononuclear phagocytes originate in the bone marrow. The colony forming cells are the committed precursors common to the granulocytic and monocytic lines. The proliferation of the colony forming cells requires a substance or substances which possess colony stimulating activity (CSA). The principal cell in the peripheral blood responsible for the elaboration of colony stimulating activity is the monocyte (7). The close ancestral relationship between granulocytes and monocytes may explain the proliferation of both cell populations in the neoplastic process of myelomonocytic leukemia. The normal function of the monocyte is retained in cells of monocytic and myelomonocytic leukemia (9). The serum colony stimulating activity was found to correlate with the level of circulating monocytes (18). Monocyte-derived macrophages and tissue macrophages are also active producers of CSA (8). Since tissue macrophages retain their function during severe bone marrow failure, these cells may serve as a reservoir of production of CSA for restoration of granulopoiesis.

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Authors and Affiliations

  1. Department of Experimental Medicine and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

    M. Rachmilewitz, B. Rachmilewitz, M. Chaouat, H. Zlotnik & M. Schlesinger

Authors
  1. M. Rachmilewitz
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  2. B. Rachmilewitz
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  3. M. Chaouat
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  4. H. Zlotnik
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  5. M. Schlesinger
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Editor information

Editors and Affiliations

  1. Medical College of Virginia, Richmond, Virginia, USA

    Mario R. Escobar

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1980 Plenum Press, New York

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Rachmilewitz, M., Rachmilewitz, B., Chaouat, M., Zlotnik, H., Schlesinger, M. (1980). The Mononuclear Phagocyte System and Hemopoiesis. In: Escobar, M.R., Friedman, H. (eds) Macrophages and Lymphocytes. Advances in Experimental Medicine and Biology, vol 121B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3593-1_38

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  • DOI: https://doi.org/10.1007/978-1-4684-3593-1_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3595-5

  • Online ISBN: 978-1-4684-3593-1

  • eBook Packages: Springer Book Archive

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