Quercetin, a Regulator of Polymorphonuclear Leukocyte (PMNL) Functions

  • C. Schneider
  • G. Berton
  • S. Spisani
  • S. Traniello
  • D. Romeo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


The binding of certain small peptides, proteins or amphipathic compounds to the surface of polymorphonuclear leukocytes (PMNL) may promote a specific activation of cell functions, such as motility, endocytosis, oxidative metabolism and secretion (9,10,12–18,20,23,25,26,31,33,35,37,39,41). The molecular mechanisms, by which this surface interaction is translated into “signals” stimulating various biochemical pathways in the PMNL, have been the subject of intense investigation for several years. The current theory is that the coordinated response of PMNL to environmental changes is triggered by a cascade of events, presumably with the utilization of some key steps for the stimulation of various cell activities. For example, an elevation of cytosol free calcium concentrations appears to be required for the enhancement of PMNL directional locomotion (38), oxidative metabolism (24,28,30) and extracellular secretion of granule enzymes (34,40).


Polymorphonuclear Leukocyte FEBS Letter Bactericidal Mechanism Leukocyte Function Cytosol Free Calcium Concentration 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • C. Schneider
    • 1
  • G. Berton
    • 2
  • S. Spisani
    • 3
  • S. Traniello
    • 3
  • D. Romeo
    • 1
  1. 1.Istituto di Chimica BiologicaUniversità di TriesteTriesteItaly
  2. 2.Istituto di Patologia GeneraleUniversità di TriesteTriesteItaly
  3. 3.Istituto di Chimica BiologicaUniversità di FerraraFerraraItaly

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