Suppression of Immunological Responsiveness in Aged Mice and Its Relationship with Coenzyme Q Deficiency

  • E. G. Bliznakov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


In 1957, Crane and his group (13) extracted from beef heart mitochondria, a new compound-coenzyme Q- “capable of undergoing reversible oxidation and reduction.” Today, coenzyme Q (Fig. 1) is accepted as a substance universally present in bacteria, plants and animals and as an essential constituent of the electron transport processes of respiration and coupled oxidative phosphorylation in mitochondria. The site of action of coenzyme Q is between NADH and succinate dehydrogenase and the cytochrome complex (reviewed in (17). Thus, coenzyme Q is indispensable for the intracellular energy metabolism and its deficiency is linked to the development of many pathological processes in cardiac, gingival and distrophic tissues of humans and animals. The existing literature was reviewed recently, and the creation of a new nosologic group of diseases was proposed--diseases of bioenergetics (19).


Aged Mouse Immunological Responsiveness Host Defense System Thymus Weight Thymus Function 
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  1. 1.
    B and T Cells in Immune Recognition (Eds. F. Loor and G. E. Roelants) John Wiley & Sons Ltd., London (1977).Google Scholar
  2. 2.
    Bach, M. A. and Beaurain, G., Ann. Immunol., 127c (1976) 967.Google Scholar
  3. 3.
    Bliznakov, E. G., Proc. Nat. Acad. Sci. (USA) 70 (1973) 390.CrossRefGoogle Scholar
  4. 4.
    Bliznakov, E. G., The Reticuloendothelial System in Health and Disease: Functions and Characteristics (Eds. Sh. M. Reichard, M. R. Escobar and H. Friedman) Plenum Publishing Corp., New York (1976) 441.Google Scholar
  5. 5.
    Bliznakov, E. G., Biomedical and Clinical Aspects of Coenzyme Q (Eds. K. Folkers and Y. Yamamura) Elsevier/North-Holland Biomedical Press, Amsterdam (1977) 73.Google Scholar
  6. 6.
    Bliznakov, E. G., Mech. Age. Dev., 7 (1978) 189.CrossRefGoogle Scholar
  7. 7.
    Bliznakov, E. G., Casey, A., Kishi, T., Kishi, H. and Folkers, K., J. Vit. Nutr. Res. 45 (1975) 388.Google Scholar
  8. 8.
    Bliznakov, E. G., Watanabe, T., Saji, S. and Folkers, K., (1978) submitted for publication.Google Scholar
  9. 9.
    Burnet, F. M., Lancet, II (1970) 358.Google Scholar
  10. 10.
    Burnet, F. M., Immunology, Aging, and Cancer: W. H. Freeman and Co., San Francisco, California (1976).Google Scholar
  11. 11.
    Cancer Incidence in Five Continents (Eds. R. Doll, C. Muir and J. Waterhouse ), UICC (1970).Google Scholar
  12. 12.
    Claman, H. N., Ann. N. Y. Acad. Sci., 249 (1975) 27.CrossRefGoogle Scholar
  13. 13.
    Crane, F. L., Hatefi, Y., Lester, R. L. and Widmer, C., Biochem. Biophys. Acta, 25 (1957) 220.CrossRefGoogle Scholar
  14. 14.
    Denckla, W. D., Fed. Proc. 37 (1978) 1263.Google Scholar
  15. 15.
    Deschaux, P. and Fontanges, R., Ann. Endocrinol., 39 (1978) 23.Google Scholar
  16. 16.
    Du, J. T., Beyer, T. A. and Lang, C. A., Exp. Gerontol., 12 (1977) 181.PubMedCrossRefGoogle Scholar
  17. 17.
    Ernster, L., Biomedical and Clinical Aspects of Coenzyme Q (Eds. K. Folkers and Y. Yamamura) Elsevier/North-Holland Biomedical Press, Amsterdam (1977) 15.Google Scholar
  18. 18.
    Fabris, N., Pierpaoli, W. and Sorkin, E., Nature, 240 (1972) 557.PubMedCrossRefGoogle Scholar
  19. 19.
    Folkers, K., Watanabe, T., Pinphanickhakarn, V., Wan, Y., Porter, Th. Azuma, Biomedical and Clinical Aspects of Coenzyme Q (Eds. K. Folkers and Y. Yamamura) Elsevier/North-Holland Biomedical Press, Amsterdam (1977) 299.Google Scholar
  20. 20.
    Gerbase-T)eLima, M., Wilkinson, J., Smith, G. S. and Walford, R. L., J. Gerontol., 29 (1974) 261.Google Scholar
  21. 21.
    Heidrick, M. L. and Makinodan, T., Gerontologia, 18 (1972) 305.PubMedCrossRefGoogle Scholar
  22. 22.
    Hirokawa, K. and Makinodan, T., J. Immunol., 114 (1975) 1659.Google Scholar
  23. 23.
    Kay, M. M. B., Aging and the Decline of Immune Responsiveness in Basic and Clinical Immunology (Eds. H. H. Fudenberg et al.) Lange Medical Publications, Los Altos, California (1976) 267.Google Scholar
  24. 24.
    MacKinney, A. A., Jr., J. Gerontol., 33 (1978) 213.PubMedGoogle Scholar
  25. 25.
    Makinodan, T. and Peterson, W. J., J. Immunol., 93 (1964) 886PubMedGoogle Scholar
  26. 26.
    Makinodan, T., Wigzell, H. and Wagner, H. N., Aging and the Immune Function, MSS Information Corp., New York, New York (1974).Google Scholar
  27. 27.
    Miller, J. F. A. P., Int. Arch. Allergy Appl. Immunol., 49 (1975) 230.PubMedCrossRefGoogle Scholar
  28. 28.
    Pachciarz, J. A. and Teague, P. 0., J. Immunol., 116 (1976) 982.Google Scholar
  29. 29.
    Patel, M. S., J. Gerontol., 32 (1977) 643.PubMedGoogle Scholar
  30. 30.
    Segre, D. and Segre, M., Mech. Age. Dev., 6 (1977) 115.CrossRefGoogle Scholar
  31. 31.
    Siliprandi, D., Siliprandi, N., Scutari, G. and Zoccarato, F., Biochem. Biophys. Res. Commun., 55 (1973) 563.CrossRefGoogle Scholar
  32. Teasdale, C., Thatcher, J., Whitehead, R. H. and Hughes, L. E., Lancet, I (1976) 1410.Google Scholar
  33. 33.
    Walford, R. L., The Immunologic Theory of Aging, Munksgaard, Copenhagen (1969).Google Scholar
  34. 34.
    Walford, R. L., J. Immunol., 117 (1976) 352.PubMedGoogle Scholar
  35. 35.
    Wilson, P. D., Gerontologia, 19 (1973) 79.PubMedCrossRefGoogle Scholar
  36. 36.
    Wilson, P. D. and Franks, L. M., Gerontologia, 21 (1975) 81.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • E. G. Bliznakov
    • 1
  1. 1.New England InstituteRidgefieldUSA

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