Functional Similarity and Diversity in Peritoneal Macrophage Populations Induced in Vivo by Various Stimuli

  • R. Goldman
  • Z. Bar-Shavit
  • A. Raz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Intraperitoneal injection of various foreign substances results in an augmentation of the size of the population of peritoneal macrophages. Various functional differences between stimulated populations and “normal” resident macrophage populations have been documented in recent years (2,4,8,11,13,16,20–22, 24,28,29). The terminology used by different workers in the field for description of the functional differences, i.e. stimulated, elicited, activated, is not consistent and depends to a large extent on the parameter chosen for comparison. We would, therefore, use the general term “stimulation” to describe populations induced by the various stimuli. Special emphasis has been given to differences in the phagocytic capacity of normal and thioglycollate (4) or endotoxin (22) stimulated mouse macrophages, since an alteration in complement receptor function upon stimulation was implicated. Another aspect that is currently intensively studied is that of macrophage-target cell interaction and the relevance of activated macrophages in combating neoplasia (2,11,13,21).


Methylene Blue Yeast Cell Macrophage Population Nucleotidase Activity Macrophage Stimulation 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • R. Goldman
    • 1
  • Z. Bar-Shavit
    • 1
  • A. Raz
    • 1
  1. 1.Department of Membrane ResearchThe Weizmann Institute of ScienceRehovotIsrael

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