Glucan Induced Modification of Experimental Staphylococcus Aureus Infection in Normal, Leukemic and Immunosuppressed Mice

  • D. L. Williams
  • N. R. di Luzio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Previous studies in our laboratory have demonstrated that glucan, a βl→ polyglucose component of the cell wall of Saccharomyces cerevisiae, nonspecifically activates lymphoreticular tissue (2,7,25). The intravenous administration of glucan results in a hypertrophy of the major RE organs with an intense activation and proliferation of macrophages (30–32). Glucan administration has been demonstrated to promote tumor regression and enhance survival in rats with an allogeneic Shay chloroleukemia (8) as well as in four syngeneic murine tumor models (10). Preliminary clinical investigations have demonstrated that intralesional administration of glucan results in prompt tumor necrosis with a concomitant monocytic infiltrate (23,24). Furthermore, Israel and Edelstein (19) have also reported that intratumoral administration of glucan resulted in necrosis of the lesion with a concomitant resolution of a distant nodule. Topical application of glucan resulted in disappearance of ulcerated lesions (19,23).


Acute Pyelonephritis Saline Control Group Leukemic Mouse Aureus Infection Lymphocytic Leukemic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Adlam, C. E., Broughton, S. and Scott, M. T., Nature (London) New Biol., 235 (1972) 219.CrossRefGoogle Scholar
  2. 2.
    Ashworth, C. T., Di Luzio, N. R. and Riggi, S. J., Exp. Mol. Pathol., 1 (1963) 83.Google Scholar
  3. 3.
    Baughn, R. E. and Bonventre, P. F., Infect. Immunol., 12 (2) (1975) 346.Google Scholar
  4. 4.
    Biggar, W. D., Buran, S. and Holmes, B., Infec. Immunol., 14 (1) (1976) 6.Google Scholar
  5. 5.
    Browder, W., Jones, E., McNamee, R. and Di Luzio, N. R., Surgical Forum 27 (1976) 134.PubMedGoogle Scholar
  6. 6.
    Burgaleta, C. and Golde, D. W., Cancer Res., 37 (1977) 1734.Google Scholar
  7. 7.
    Di Luzio, N. R., Pharmacology of the reticuloendothelial system: Accent on glucan. In: The Reticuloendothelial System in Health and Disease (Functions and Characteristics), (Eds. S. M. Reichard, M. R. Escobar and H. Friedman ), Plenum Pub., N. Y., (1976) 412.Google Scholar
  8. 8.
    Di Luzio, N. R., Cook, J. A., Cohen, C., Rodrigue, J and Jones, E., The synergistic effect of cyclophosphamide and glucan on experimental acute myelogenous and lymphocytic leukemia. In: The Macrophage and Cancer., (Eds. K. James, B. McBride, A. Stuart ), Econoprint, Scotland, (1977a) 188.Google Scholar
  9. 9.
    Di Luzio, N. R., Hoffmann, E. O., Cook, J. A., Browder, W. and Mansell, P. W. A., Glucan-induced enhancement host resistance to experimental tumors. In: Control of Neoplasia by Modulation of the Immune System. (Ed. M. A. Chirigos ), Raven Press, N. Y., (1977b) 495.Google Scholar
  10. 10.
    Di Luzio, N. R., McNamee, R., Browder, W. and Williams, D. L., Cancer Tr Rep (1978) in press.Google Scholar
  11. 11.
    Gaya, H., Tattersall, M. H., Hutchinson, R. M. and Spiers, S. S., Eur. J. Cancer, 9 (1973) 401.PubMedCrossRefGoogle Scholar
  12. 12.
    Glovsky, M. M., Di Luzio, N. R., Alenty, A. and Ghekiere, L., J. Reticuloendothel. Soc, 20 (1976) 54a.Google Scholar
  13. 13.
    Golde, D. W. and Burgaleta, C., Glucan-activated macrophages: Functional properties and cytoxicity against syngeneic leukemic cells. In: Immune Modulation and Control and Neoplasia by Adjuvant Therapy, (Ed. M. Chirigos ), Raven Press, N. Y. (1978) 201.Google Scholar
  14. 14.
    Gorrill, R. H., Br. J. Exp. Pathol., 39 (2) (1958) 203.PubMedGoogle Scholar
  15. 15.
    Hassid, W. Z., Joslyn, M. A. and McCready, R. M., J. Am. Chem. Soc., 63 (1941) 295.CrossRefGoogle Scholar
  16. 16.
    Hoffmann, E. 0., Di Luzio, N. R., Cook, J. A., McNamee, R. B. and Armstrong, K., Lab. Invest., 36 (1977) 340.Google Scholar
  17. 17.
    Hughes, W. T., Am. J. Dis. Child, 122 (1971) 283.PubMedGoogle Scholar
  18. 18.
    Hughes, W. T., Adv. Intern Med., 22 (1977) 73.PubMedGoogle Scholar
  19. 19.
    Israel, L. and Edelstein, R., Treatment of cutaneous and subcutaneous metastatic tumors with intralesional glucan. In: Control of Neoplasia by Modulation of the Immune System, (Ed. M. A. Chirigos ), Raven Press, N. Y., (1978) 249.Google Scholar
  20. 20.
    Kokoshis, P. L., Williams, D. L., Cook, J. A. and Di Luzio, N. R., Science, 199 (1978) 1340.PubMedCrossRefGoogle Scholar
  21. 21.
    Ladisch, S. and Pizzo, P. A., Pediatrics, 61 (1978) 231.PubMedGoogle Scholar
  22. 22.
    Lejeune, F. J., Delville, J., Gillet, J., Song, M., Stadtsbaeder, S. and Jacques, P., Eur. J. Cancer (1978) in press.Google Scholar
  23. 23.
    Mansell, P. W. A., Ichinose, H., Reed, R. J., Krementz, E. T., McNamee, R. and Di Luzio, N. R., J. Natl. Cancer Inst., 54 (1975) 571.PubMedGoogle Scholar
  24. 24.
    Mansell, P. W. A., Di Luzio, N. R., McNamee, R., Rowden, G. and Proctor, J. W., Ann. N. Y. Acad. Sci, 277 (1976) 20.CrossRefGoogle Scholar
  25. 25.
    Riggi, S. J. and Di Luzio, N. R., Am. J. Physiol., 200 (1961) 297.PubMedGoogle Scholar
  26. 26.
    Sharbaugh, R. T. and Grogan, J. B., Infec. Immunol., 100 (1969) 117.Google Scholar
  27. 27.
    Sher, N. A., Chaparas, S. D., Greenburg, L. E. and Bernard, S., Infec. Immunol., 12 (1975) 1325.Google Scholar
  28. 28.
    Steven, M., Steven, P., Cook, J. A., Ichinose, H. and Di Luzio, N. T., J. Reticuloendothel. Soc., 20 (1976) 66a.Google Scholar
  29. 29.
    Williams, D. L., Cook, J. A., Hoffmann, E. 0. and Di Luzio, N. R., J. Reticuloendothel. Soc., (1978) in press.Google Scholar
  30. 30.
    Wooles, W. R. and Di Luzio, N. R., Am. J. Physiol., 203 (1962) 404.PubMedGoogle Scholar
  31. 31.
    Wooles, W. R. and Di Luzio, N. R., Science, 142 (1963) 1078.PubMedCrossRefGoogle Scholar
  32. 32.
    Wooles, W. R. and Di Luzio, N. R., J. Reticuloendothel. Soc., 1 (1964) 160.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • D. L. Williams
    • 1
  • N. R. di Luzio
    • 1
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA

Personalised recommendations