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Macrophages and Lymphocytes pp 157–166Cite as

Effect of Proteinases on EA (IgG)-Binding Receptors of Rat Macrophages

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 121B))

Abstract

Reports about the proteinase sensitivity of macrophage receptors for IgG (Fc-receptor) are equivocal. Sorkin (10) studying binding of cytophilic antibody to rabbit splenic macrophages found the binding diminished after treatment with proteolytic enzymes. Other authors, however, found an enhanced (1, 2) or unchanged (4, 7, 9) Fc-receptor activity after proteinase treatment of macrophages from various species. On mouse macrophages 2 different Fc-receptors for rabbit IgG were reported, 1 for aggregated IgG being trypsin resistant, another for monomeric mouse IgG2a being sensitive to digestion by trypsin (3, 11).

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Author information

Authors and Affiliations

  1. Institute of General and Experimental Pathology, University of Vienna, Vienna, Austria

    G. Boltz-Nitulescu & O. Förster

Authors
  1. G. Boltz-Nitulescu
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  2. O. Förster
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Editor information

Editors and Affiliations

  1. Medical College of Virginia, Richmond, Virginia, USA

    Mario R. Escobar

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1980 Plenum Press, New York

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Boltz-Nitulescu, G., Förster, O. (1980). Effect of Proteinases on EA (IgG)-Binding Receptors of Rat Macrophages. In: Escobar, M.R., Friedman, H. (eds) Macrophages and Lymphocytes. Advances in Experimental Medicine and Biology, vol 121B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3593-1_14

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  • DOI: https://doi.org/10.1007/978-1-4684-3593-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3595-5

  • Online ISBN: 978-1-4684-3593-1

  • eBook Packages: Springer Book Archive

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