Evidence that Phagocytosing Chicken Polymorphonuclear Leukocytes Generate Hydrogen Peroxide and Superoxide Anion

  • P. Dri
  • P. Bellavite
  • R. Cramer
  • B. Bisiacchi
  • F. Cian
  • P. Patriarca
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Polymorphonuclear leukocytes (PMN) are known to produce hydrogen peroxide during the respiratory stimulation associated with the ingestion of particles (9,10,19,24). The oxygen taken up by the cell is univalently reduced to superoxide anion (O2 ) which, in turn, dismutates with formation of hydrogen peroxide. The fate of hydrogen peroxide in these cells is dual, a) it may be destroyed within the cell by enzymes such as myeloperoxidase, catalase or glutathione peroxidase, and/or b) it may leak out of the cell, the amount of peroxide released depending at least on the rate of formation and the efficiency of the intracellular H2O2 destroying systems.


Oxygen Uptake H202 Production Vanillic Acid NADPH Oxidase Activity Homovanillic Acid 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • P. Dri
    • 1
  • P. Bellavite
    • 1
  • R. Cramer
    • 1
  • B. Bisiacchi
    • 1
  • F. Cian
    • 1
  • P. Patriarca
    • 1
  1. 1.Instituto di Patologia GeneraleTriesteItaly

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