Association of Some Metabolic Activities of Leukocytes with the Immune Response

  • R. R. Strauss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Phagocytosis is a physiological function of many different mammalian cell types. These phagocytic cells remove dead cells, tissue, and foreign substances from the body by engulfment and digestion of these materials. Some phagocytic cells, notably the neutrophils, monocytes and macrophages, also serve as primary factors in the host-defense mechanism by engulfing, killing and digesting pathogenic microorganisms. Macrophages have also been implicated in the killing of tumor cells and the humoral immune response. Stimulation of a number of biochemical and metabolic parameters has been associated with phagocytosis. These include increased glucose utilization, 114C-glucose oxidation, 614C-glucose oxidation, oxygen consumption, NADPH oxidase activity, peroxidase activity, superoxide anion production, H2O2 production and chemoluminescence. These biochemical and metabolic activities of phagocytes and their relationship to particle engulfment and intracellular microbicidal activity have been reviewed in detail by Karnovsky (11) and others (23). This report will be concerned with the association of some metabolic activities of mouse macrophages and the immune response. It seems as if some of the metabolic activities that have been related to phagocytosis and killing of microorganisms by macrophage and neutorphils may also be associated with cellular and humoral immunity.


Trypan Blue Spleen Cell NADPH Oxidase Activity Sheep Erythrocyte Spleen Weight 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • R. R. Strauss
    • 1
  1. 1.Northern DivisionAlbert Einstein Medical CenterPhiladelphiaUSA

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