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Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function

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Modulators, Mediators, and Specifiers in Brain Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 116))

Abstract

A large body of evidence has accumulated indicating that protein phosphorylation plays an important role in the regulation of metabolic processes in eukaryotic cells. Thus, glycogenolysis, glycogen synthesis and lipolysis are controlled, respectively, by the phosphorylation of glycogen phosphorylase-kinase, glycogen-synthetase and triglyceride-lipase (for review see RUBIN and ROSEN, 1975). Subsequent to these initial discoveries, it was found that the phosphorylation of proteins is involved in the regulation of a diversity of physiological and metabolic processes occuring in many different organs. In addition, it has been demonstrated that in each of these organs the process of protein phosphorylation is influenced by physiological affectors that regulate cellular functions in the respective target tissue (e.g. polypeptide hormones, steroid hormones, cyclic nucleotides, calcium ions, etc.). The integration of all these findings has led to the suggestion (GREENGARD, 197 8a) that the phosphorylation of proteins may be a final common pathway for a diversity of biological regulatory agents.

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Authors and Affiliations

  1. The Missouri Institute of Psychiatry, School of Medicine, University of Missouri-Columbia, St. Louis, Missouri, 63139, USA

    Yigal H. Ehrlich

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  1. Yigal H. Ehrlich
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Editors and Affiliations

  1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, Missouri, USA

    Yigal H. Ehrlich , Jan Volavka , Leonard G. Davis  & Eric G. Brunngraber , ,  & 

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Ehrlich, Y.H. (1979). Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function. In: Ehrlich, Y.H., Volavka, J., Davis, L.G., Brunngraber, E.G. (eds) Modulators, Mediators, and Specifiers in Brain Function. Advances in Experimental Medicine and Biology, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3503-0_5

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  • DOI: https://doi.org/10.1007/978-1-4684-3503-0_5

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