Abstract
In a symposium devoted to the discussion of modula tors, mediators and specifiers in brain, it seems propitious first to address the issue of what these agents are and what criteria may be developed to define them. This task seems particularly timely now because of the burgeoning number of substances found in brain which seem not to strictly fit our preconceived notions of a neurotransmitter. Therefore, after developing criteria for neurotransmitters, mediators and modulators, I will provide examples of substances that could satisfy the criteria for these classifications, with special emphasis on norepinephrine (NE), cyclic AMP and the opioid peptides.
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Siggins, G.R. (1979). Neurotransmitters and Neuromodulators and their Mediation by Cyclic Nucleotides. In: Ehrlich, Y.H., Volavka, J., Davis, L.G., Brunngraber, E.G. (eds) Modulators, Mediators, and Specifiers in Brain Function. Advances in Experimental Medicine and Biology, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3503-0_3
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