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Adaptive Alterations in Receptor Mediated Processes and their Implications for Some Mental Disorders

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Modulators, Mediators, and Specifiers in Brain Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 116))

Abstract

The locus and mechanisms of long-lasting adaptation in neural systems have been the subject of intensive re search efforts for many years. Prominent among early efforts was the demonstration of an increased sensitivity to acetylcholine in denervated skeletal muscle (CANNON and ROSENBLUTH, 1949). More recently, the technology for the direct study of high affinity receptor binding specific to individual neurotransmitters has evolved and with it has grown our knowledge of the complexity of receptor-ligand interactions and subsequent coupling to effector sites in the target cell. It has become clear that cell surface receptors for neurotransmitters can undergo long-lasting changes in sensitivity to ligand that are reciprocal to the frequency of ligand encounter (FRIEDHOFF, 1977). It is further apparent that in some instances the elements coupling cell surface receptors to an effector complex within the cell are capable of independent adaptation. Finally, it is evident that the purposeful manipulation of these receptor systems, by pharmacological strategies, may provide novel means by which to produce long-lasting remediation of some clinical disorders possibly resulting from receptor dysfunction.

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References

  • ALPERT, M., FRIEDHOFF, A., MARCOS, L., & DIAMOND, F. (1978) Amer. J. Psychiat., 135, 1329–1332.

    PubMed  CAS  Google Scholar 

  • AXELROD, J. & ZATZ, M. (1977) In: Biochemical Actions of Hormones. Vol. 4, pp. 249–268. Acad. Press, N.Y.

    Google Scholar 

  • BAR, R. S., HARRISON, L., MUGGEO, M., GORDEN, P., KAHN, C. R. & ROTH, J. (1979) In: Advances in Internal Medicine (in-press).

    Google Scholar 

  • BONNET, K. A., HILLER, J. M. & SIMON, E. J. (1976) In: Opiates and Endogenous Opioid Peptides. (Kosterlits , H. W., ed) pp. 335–344, North Holland Publishing, Amsterdam.

    Google Scholar 

  • BONNET, K. A., BRANCHEY, L., FRIEDHOFF, A. J. & EHRLICH, Y. H. (1977) Committee on Problems of Drug Dependence, Cambridge, Mass., July.

    Google Scholar 

  • BONNET, K. A., BRANCHEY, L., FRIEDHOFF, A. J. & EHRLICH, Y. H. (1978) Life Sciences, 22, 2003–2008.

    Article  PubMed  CAS  Google Scholar 

  • BONNET, K. A., GUSIK, S., & SUNSHINE, A. G. (1978) In: Characteristics and Functions of the Opioids. (Van Ree, J. & Terenius, L., eds.). pp. 453–464.

    Google Scholar 

  • BLUME, A. J. (1978) Proc. Nat. Acad. Sci. USA, 75, 1713–1717.

    Article  PubMed  CAS  Google Scholar 

  • BROSTROM, C. O. & WOLFF, D. J. (1976) Arch. Bioch. Biophys. 172, 301–311.

    Article  CAS  Google Scholar 

  • CANNON, W. B. & ROSENBLUTH, A. (1949) The Supersensitivity of Denervated Structures: A Law of Denervation. MacMillan, New York.

    Google Scholar 

  • CARLSSON, A. (1970) In: L-DOPA and Parkinsonism (Barbeau, A. and McDowell, F.. pp. 2O5ff. F.A. Davis Co., Philadelphia.

    Google Scholar 

  • CARLSSON, A. & LINDQUIST, M. (19 63) Acta Pharmacol. Toxicol. 20, 140–143.

    Article  CAS  Google Scholar 

  • CHEUNG, W. Y., LYNCH, T., & TALLANT, E. (1976) Bioch. Biophys. Res. Commun., 68, 616–621.

    Article  Google Scholar 

  • CHIU, T. & ROSENBERG, H. P. (1978) Life Sci., 23, 1153– 1158.

    Article  PubMed  CAS  Google Scholar 

  • CLARK, A. G., JOVIC, R., ORNELLAS, M. R. & WELLER, M. (1972) Bioch. Pharmacol., 21, 1989–1999.

    Article  CAS  Google Scholar 

  • CLOUET, D. H., & IWATSUBO, M. (1975) In: The Opiate Narcotics (Goldstein, A., ed.) pp. 189–194. Pergammon Press, New York.

    Google Scholar 

  • COLLIER, H. O. J. (1966) In: Advances in Drug Research. 3, 171–188.

    Google Scholar 

  • COLLIER, H. O. J. & FRANCIS, D. L. (1975) Nature , 255, 159–161.

    Article  PubMed  CAS  Google Scholar 

  • CREESE, I., BURT, D. & SNYDER, S. H. (197 7) Science , 197, 596–598.

    Article  PubMed  CAS  Google Scholar 

  • DEGUCHI, T. & AXELROD, J. (1973) Proc. Nat. Acad. Sci. USA., 70, 2411–2414.

    Article  PubMed  CAS  Google Scholar 

  • EHRLICH, Y. H., DAVIS, L. G., GILFOIL, T. & BRUNNGRABER, E. G. (1977) Neurochem. Res., 3, 533–548.

    Article  Google Scholar 

  • EHRLICH, Y. H., BONNET, K. A., DAVIS, L. G. & BRUNNGRABER, E. G. (1978) Life Sciences, 23, 137–146.

    Article  PubMed  CAS  Google Scholar 

  • EZIN-WATERS, C. & SEEMAN, P. (1977) Life Sci., 22, 1027– 1032.

    Google Scholar 

  • FREDHOLM, B. B. (1977) Medical Biology, 55, 61–65.

    PubMed  CAS  Google Scholar 

  • FRIEDHOFF, A. J. (1977) In: Psychopathology and Brain Dysfunction (Shagass, C., Gershon, s. and Friedhoff, A. J., eds.). pp. 139–148. Raven Press, New York.

    Google Scholar 

  • FRIEDHOFF, A. J., BONNET, K. A. & ROSENGARTEN, H. (1977) Res. Commun. Chem. Pathol. Pharmacol., 16 , 411–423.

    PubMed  CAS  Google Scholar 

  • FRIEDHOFF, A. J., and ALPERT, M. (19 79) Proceedings of Fourth Annual Catecholamine Symposium, Pacific Grove, Calif. (in-press).

    Google Scholar 

  • GAVIN, J. R., ROTH, J. & NEVILLE, D. M. (1974) Proc. Nat. Acad. Sci. USA., 71, 84.

    Google Scholar 

  • GNEGY, M., UZUNOV, P., & COSTA, E. (1976) Proc. Nat. Acad. Sci. USA., 73, 3887–3890.

    Article  PubMed  CAS  Google Scholar 

  • GNEGY, M., UZUNOV, P., & COSTA, E. (1977) J. Pharm. Exp. Ther., 202, 558–564.

    CAS  Google Scholar 

  • GOLD, M. S., REDMOND, D. E. & KLEBER, H. D. (1978) Lancet September 16. 599–601.

    Article  Google Scholar 

  • GOLDSTEIN, S., BLECHER, B., BINDER, R., PERINNO, P. V. & RACANT, L. (1975) Endocrinol. Res. Commun. 2, 367-376. GROSZ, H. J. (1973) Lancet, 2, 612.

    Article  Google Scholar 

  • HINKLE, P. M. & TASHJIAN, H.,JR. (1975) Biochemistry, 14, 3845–3851.

    Article  PubMed  CAS  Google Scholar 

  • IWATSUBO, K. & CLOUET, D. H. (1975) Bioch. Pharmacol., 24, 1499–1503.

    Article  CAS  Google Scholar 

  • KATZ, B. & THESLEFF, S. (1957) J. Physiol., 138, 63–80.

    PubMed  CAS  Google Scholar 

  • KEBABIAN, J. W., ZATZ, M., ROMERO, J. A. & AXELROD, J. (1975) Proc. Nat. Acad. Sci. USA, 72, 3735–3739.

    Article  PubMed  CAS  Google Scholar 

  • KEBABIAN, J. W (1978) Life Sciences, 23, 479–484.

    Article  PubMed  CAS  Google Scholar 

  • KEBABIAN, J. W. & CALNE, D. B. (1979) Nature, 277, 93–96.

    Article  PubMed  CAS  Google Scholar 

  • KLAWANS, H. L., SLAKI, M. M. & SHENKER, D. (1970) Acta. Neurol. Schand., 46, 409–411.

    Article  Google Scholar 

  • LEFKOWITZ, R. J. & MUKHERJEE, C. (1976) Proc. Nat. Acad. Sci. USA., 73, 1494–1498.

    Article  PubMed  Google Scholar 

  • LEFKOWITZ, R. J., MULLIKIN, D., WOOD, C, GORE, T. & MUKHERJEE, C. (1977) J. Biol. Chem., 252, 5295–5303.

    PubMed  CAS  Google Scholar 

  • LEFKOWITZ, R. J., MULLIKIN, D., & WILLIAMS, L. T. (1978) Molec. Pharmacol., 14, 376–380.

    CAS  Google Scholar 

  • LEFKOWITZ, R. J. (1978) In:Neuronal Information Transfer(Karlin, A., Tennyson, V. M. & Vogel, H. J., eds.) pp. 59–7 2. Academic Press, New York.

    Google Scholar 

  • LLORENS, C., WATERS, M., BAUDRY, M., & SCHWARTZ, J. (1978) Nature, 274, 603–605. MERALI, Z. & SINGHAL, R. (1975) Life Sci., 16, 1889-1894.

    Article  PubMed  CAS  Google Scholar 

  • MISHRA, R. K., WONG, Y.-W., VARMUZE, S. L. & TUFF, L. (1978) Life Sciences, 23, 443–446.

    Article  PubMed  CAS  Google Scholar 

  • MOTOMATSU, T., LIS, M., SEIDAH, N. & CHRETIEN, M. (1977) Bioch. Biophys. Res. Commun., 77, 442–447.

    Article  CAS  Google Scholar 

  • MULLER, P. & SEEMAN, P. (1978) Psychopharmacol. 60, 1–11.

    Article  CAS  Google Scholar 

  • PECKER, F. & HANOUNE, J. (1977) FEBS Lett., 83, 93–98.

    Article  PubMed  CAS  Google Scholar 

  • PURI , S. K., COCHIN, J. & VOLICER, L. (1975) Life Sci., 16, 759–768.

    Article  PubMed  CAS  Google Scholar 

  • RODBELL, M., KRANS, HM. J., PHOL, J. & BIRNBAUMER, L. (1971) J. Biol. Chem., 246, 1872–1876.

    PubMed  CAS  Google Scholar 

  • ROMERO, J. A., & AXELROD, J. (1975) Proc. Nat. Acad. Sci. USA. 72, 1661–1665.

    Article  PubMed  CAS  Google Scholar 

  • ROSENGARTEN, H. & FRIEDHOFF, A. J. (1979) Science, (in-press).

    Google Scholar 

  • SCHWARZ, R., FUXE, K., AGNATI, L. & GUSTAFSSON, J.-A. (1978) Life Sci., 23, 465–470.

    Article  Google Scholar 

  • SHARMA, S. K., KLEE, W. A. & NIRENBERG, M. (1977) Proc. Nat. Acad. Sci. USA. 74, 3365–3369.

    Article  PubMed  CAS  Google Scholar 

  • SOLL, A. H., KAHN, C. R. & NEVILLE, D. M. (1975) J. Biol. Chem. 250, 4702–4707.

    PubMed  CAS  Google Scholar 

  • SOLL, A. H., GOLDFINE, I. D. & ROTH, J. (1974) J. Biol. Chem. 249, 4127–4131.

    PubMed  CAS  Google Scholar 

  • STRIMWATTER, W. J., DAVIS, J. N. & LEFKOWITZ, R. J. (1977) J. Biol. Chem., 252, 5472–5477.

    Google Scholar 

  • VETULANI, J., STAWARZ, R., SULSER, F. (1976) J. Neurochem. 27, 661–666.

    Article  PubMed  CAS  Google Scholar 

  • WILLIAMS, L. T. & LEFKOWITZ, R. J. (1977) J. Biol. Chem. 252, 7202–7213.

    Google Scholar 

  • YAMAMOTO, H., HARRIS, R., LOH, H. H. & WAY, E. L. (1978) J. Pharm. Exp. Ther., 205, 255–264.

    CAS  Google Scholar 

  • ZAHNISER, N. R. & MOLINOFF, P. B. (197 8) Nature, 275, 453–455.

    Article  PubMed  CAS  Google Scholar 

  • ZATZ, M. (1977) Life Sciences, 21, 1267–1276.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Millhauser Laboratories Department of Psychiatry, New York University School of Medicine, New York, New York, 10016, USA

    Kenneth A. Bonnet

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  1. Kenneth A. Bonnet
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Editors and Affiliations

  1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, Missouri, USA

    Yigal H. Ehrlich , Jan Volavka , Leonard G. Davis  & Eric G. Brunngraber , ,  & 

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© 1979 Plenum Press, New York

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Bonnet, K.A. (1979). Adaptive Alterations in Receptor Mediated Processes and their Implications for Some Mental Disorders. In: Ehrlich, Y.H., Volavka, J., Davis, L.G., Brunngraber, E.G. (eds) Modulators, Mediators, and Specifiers in Brain Function. Advances in Experimental Medicine and Biology, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3503-0_14

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  • DOI: https://doi.org/10.1007/978-1-4684-3503-0_14

  • Publisher Name: Springer, Boston, MA

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