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The Behaviorally Active Neuropeptide ACTH as Neurohormone and Neuromodulator: The Role of Cyclic Nucleotides and Membrane Phosphoproteins

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Modulators, Mediators, and Specifiers in Brain Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 116))

Abstract

Investigations on the role of the pituitary-adrenal system in the adaptation of the organism to environmental stimuli, led de Wied to postulate that the pituitary would manufacture peptides which modulate behavior by a direct action on the brain (neuropeptides; DE WIED, 1969). Indeed, fragments of hormones of both the posterior pituitary (vasopressin, oxytocin) and the anterior pituitary (ACTH, MSH, ß-LPH) were found to possess strong behavioral activity which was clearly dissociated from effects on the endocrinon. Much effort was given to characterize the effects of the peptides on animal behavior and the significance of the research on behaviorally active peptides became eminent when independent reports in the literature pointed to a physiological role of known and hitherto unknown peptides in normal and abnormal human behavior (DE WIED and GISPEN, 1977; DE WIED, 1978). To date research on neuropeptides is a multidisciplinary struggle to unravel their location in the brain and their mechanism of action in terms of electrophysiological and neurochemical events and to assess their usefulness in the treatment of brain and behavioral diseases.

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Authors and Affiliations

  1. Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, Laboratory of Physiological Chemistry, Medical Faculty, Institute of Molecular Biology, University of Utrecht, Padualaan 8, Utrecht, The Netherlands

    W. H. Gispen, H. Zwiers, V. M. Wiegant, P. Schotman & J. E. Wilson

  2. Department of Biochemistry and Nutrition, Medical School, UNC, Chapel Hill, N.C., USA

    J. E. Wilson

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  1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, Missouri, USA

    Yigal H. Ehrlich , Jan Volavka , Leonard G. Davis  & Eric G. Brunngraber , ,  & 

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Gispen, W.H., Zwiers, H., Wiegant, V.M., Schotman, P., Wilson, J.E. (1979). The Behaviorally Active Neuropeptide ACTH as Neurohormone and Neuromodulator: The Role of Cyclic Nucleotides and Membrane Phosphoproteins. In: Ehrlich, Y.H., Volavka, J., Davis, L.G., Brunngraber, E.G. (eds) Modulators, Mediators, and Specifiers in Brain Function. Advances in Experimental Medicine and Biology, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3503-0_11

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