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Ovarian Follicular and Corpus Luteum Function pp 361–373Cite as

Inhibition of in Vivo and in Vitro FSH Secretion by Steroid-Free Hamster Ovarian Extracts

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 112))

Abstract

We designed experiments to determine if a nonsteroidal substance capable of inhibiting the secretion of follicle-stimulating hormone (FSH) exists in the hamster ovary. Proestrous hamster ovaries were homogenized, centrifuged, and treated with dextrancoated charcoal for removal of steroids. Charcoal-treated ovarian extract (CTOE) was injected intraperitoneally at hourly intervals into phenobarbital-treated (phen-treated) proestrous hamsters immediately after ovariectomy at 1300. The CTOE inhibited the selective rise in serum FSH that occurred in phen-treated, ovariectomized (ovx) controls.

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Author information

Authors and Affiliations

  1. Oregon Regional Primate Research Center, Reproductive Physiology, 505 N.W. 185th Avenue, Beaverton, Oregon, 97005, USA

    S. C. Chappel, T. Acott & H. G. Spies

Authors
  1. S. C. Chappel
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  2. T. Acott
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  3. H. G. Spies
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Cornelia P. Channing

  2. Department of Biochemistry, University of Miami School of Medicine, Miami, Florida, USA

    John M. Marsh

  3. Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA

    William A. Sadler

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© 1979 Plenum Press, New York

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Chappel, S.C., Acott, T., Spies, H.G. (1979). Inhibition of in Vivo and in Vitro FSH Secretion by Steroid-Free Hamster Ovarian Extracts. In: Channing, C.P., Marsh, J.M., Sadler, W.A. (eds) Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3474-3_41

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  • DOI: https://doi.org/10.1007/978-1-4684-3474-3_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3476-7

  • Online ISBN: 978-1-4684-3474-3

  • eBook Packages: Springer Book Archive

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