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Ovarian Follicular and Corpus Luteum Function pp 27–44Cite as

LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian Follicles

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 112))

Abstract

The preovulatory surge of LH promotes stimulation, closely followed by desensitization of the ovarian follicular adenylyl cyclase (AC) system (1–6). Desensitization of the AC system in estrous rabbit follicles is characterized by an LH-specific, dose-dependent decline in LH-stimulated AC activity and results, by definition, in a retarded rate of cAMP synthesis (2). Although a coincident decline in LH- and FSH-stimulated AC activities occurs, there is no concurrent decline in prostaglandin (PG)E1- or NaF- stimulated AC activities (2). LH refractoriness is demonstrable within min following mating of the iv injection of an ovulatory dose of hCG and is complete prior to ovulation. The follicular AC system does not acquire LH responsiveness again until 48–72 h after the induction of ovulation, when the new CL has formed. Desensitization of the AC system, then, is clearly one of the earliest events prompted by the surge of LH in follicles. However, little is known concerning the mechanism underlying the desensitizing process.

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Author information

Authors and Affiliations

  1. Department of Beochemistry, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Mary Hunzicker-Dunn, Richard Jungmann & Dennis Derda

  2. Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77035, USA

    Lutz Birnbaumer

Authors
  1. Mary Hunzicker-Dunn
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  2. Richard Jungmann
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  3. Dennis Derda
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  4. Lutz Birnbaumer
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Cornelia P. Channing

  2. Department of Biochemistry, University of Miami School of Medicine, Miami, Florida, USA

    John M. Marsh

  3. Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA

    William A. Sadler

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© 1979 Plenum Press, New York

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Hunzicker-Dunn, M., Jungmann, R., Derda, D., Birnbaumer, L. (1979). LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian Follicles. In: Channing, C.P., Marsh, J.M., Sadler, W.A. (eds) Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3474-3_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3474-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3476-7

  • Online ISBN: 978-1-4684-3474-3

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