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The Adenovirus-SV40 Hybrid Viruses

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Comprehensive Virology Volume 13: Structure and Assembly

Part of the book series: Comprehensive Virology ((CV))

Abstract

The adenovirus-simian virus 40 (Ad-SV40) hybrid viruses are stable viral recombinants which form in monkey kidney cells (MKC) coinfected with the simian papovavirus SV40 and a number of human adenovirus serotypes. The genomes of these viruses are composed mainly of Ad DNA (integrated with varying amounts of SV40 DNA) and are enclosed in capsids whose morphological and immunological properties are indistinguishable from those of the parent nonhybrid adenovirus. Studies of the Ad-SV40 hybrid viruses have made important contributions to a number of areas of molecular virology; previous reviews of these studies include those by Rapp (1973) and Lewis (1977).

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Authors and Affiliations

  1. Section on Infectious Disease Pediatric Oncology Branch National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Cephas T. Patch & Arthur S. Levine

  2. Laboratory of Viral Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Andrew M. Lewis Jr.

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  1. Cephas T. Patch
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  1. Department of Molecular Biology and Virus Laboratory, University of California, Berkeley, California, USA

    Heinz Fraenkel-Conrat

  2. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Robert R. Wagner

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Patch, C.T., Levine, A.S., Lewis, A.M. (1979). The Adenovirus-SV40 Hybrid Viruses. In: Fraenkel-Conrat, H., Wagner, R.R. (eds) Comprehensive Virology Volume 13: Structure and Assembly. Comprehensive Virology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3453-8_7

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