Abstract
Rabbit bronchus associated lymphoid tissue (BALT) (1) and Peyer’s patches (2,3) contain cells which recognize locally presented antigen, and which respond by cell division. These observations are consistent with an emerging concept that aggregated mucosal lymphoid structures “sense” lumenal antigen, and amplify the local immune response. However antigen-induced cell proliferation in vitro occurs under restricted conditions and the rate of DNA synthesis is less than that observed for circulating cells following systemic immunization (1,3). The reason(s) for this difference between mucosal and circulating lymphocytes is not clear, but the demonstration of a suppressor cell population within the mouse Peyer’s patch, suggests that cell-dependent regulation may limit the local inflammatory response to environmental antigen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Clancy, R. and Bienenstock, J., J. Immunol. 112: 1997, 1974.
Pierce, N. and Gowans, J., J. Exp. Med. 142: 1550, 1975.
Clancy, R., unpublished observations.
Clancy, R. and Pucci, A., Gut, in press, 1978.
Boyum, A., Scand. J. Clin. Lab. Invest. 21 Suppl. 97, 1968.
Dent, P., Natl. Cancer Inst. 46: 763, 1971.
Kaplan, M. and Clark, J., J. Immunol. Meth. 12: 285, 1976.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Clancy, R., Pucci, A. (1978). Human Mucosal Lymphocytes — Memory for ‘Recall’ Antigens and Non-Specific Suppression by T-Lymphocytes. In: McGhee, J.R., Mestecky, J., Babb, J.L. (eds) Secretory Immunity and Infection. Advances in Experimental Medicine and Biology, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3369-2_65
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3369-2_65
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3371-5
Online ISBN: 978-1-4684-3369-2
eBook Packages: Springer Book Archive