The Partial Isolation and Function of Salivary Factors Which Interact with the Complement System: a Possible Role in Mucosal Immunity
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Penetration of oral bacterial substances, coated with salivary constituents, into damaged mucosa and subsequent contact with serum complement components is an example of the potential for saliva-complement reactions. These interactions may affect not only the production of the potent complement-generated anaphylatoxins and chemotactic factors, C3a and C5a, but also other immunological responses which depend to varying extents on complement activation. These include stimulation of the differentiation of B lymphocytes to become antibody-producing plasma cells, B-cell-mediated cytotoxicity, and stimulation of macrophages and polymorphonuclear leukocytes to release lysosomal proteolytic enzymes. Stimulation of these cells is thought to occur as a result of the attachment of complement-coated antigens to specific C3b and C5b receptors on B lymphocytes, macrophages, and polymorphonuclear leukocytes. Furthermore, saliva-coated oral antigens may contact the functional complement components in the crevicular fluid (1) prior to tissue penetration.
KeywordsComplement Component Parotid Saliva Fresh Human Serum Salivary Substance Eluant Buffer
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