Secretory Immunity and Immunodeficiency

  • Roland R. Arnold
  • Shirley J. Prince
  • Jiri Mestecky
  • Denis Lynch
  • Monica Lynch
  • Jerry R. McGhee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Naturally induced antibodies to the indigenous oral flora have been demonstrated in normal human secretions and are almost exclusively of the s-IgA class (1,2). It has been suggested that such antibodies may play an important role in the defense of the tooth surface against attack by cariogenic microorganisms, such as Streptococcus mutans (2,3). However, attempts to correlate IgA levels with caries incidence have met with contradictory results (3–8).


Dental Caries Lysozyme Activity Caries Experience High Caries Parotid Saliva 
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  1. 1.
    Bratthall, D. and Gibbons, R. J., Infect. Immun. 11: 603, 1975.PubMedGoogle Scholar
  2. 2.
    Arnold, R. R., Mestecky, J. and McGhee, J. R., Infect. Immun. 14: 355, 1976.PubMedGoogle Scholar
  3. 3.
    Lehner, T., Cardwell, J. E. and Clarry, E. D., Lancet 1: 1294, 1967.PubMedCrossRefGoogle Scholar
  4. 4.
    Robertson, P. B. and Cooper, M. D., in The Immunoglobulin A System (Edited by Mestecky, J. and Lawton, A. R.), p. 497, Plenum Press, New York, 1974.CrossRefGoogle Scholar
  5. 5.
    Zengo, A. N., Mandel, I. D., Goldman, R. and Khurana, H. S., Arch. Oral Biol. 16: 557, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Shklair, I. L., Rovelstad, G. H. and Lamberts, B. L., J. Dent. Res. 48: 842, 1969.PubMedCrossRefGoogle Scholar
  7. 7.
    Cole, M. F., Arnold, R. R., Rhodes, M. J. and McGhee, J. R., J. Dent. Res. 56: 198, 1977.PubMedCrossRefGoogle Scholar
  8. 8.
    Stuchell, R. N. and Mandel, I. D., in The Secretory Immune System and Caries Immunity (Edited by McGhee, J. R., Mestecky, J. and Bobb, J.), Plenum Publishing Corp., New York, 1978Google Scholar
  9. 9.
    Crabbé, P. A. and Heremans, J. R., Gut 7: 119, 1966.PubMedCrossRefGoogle Scholar
  10. 10.
    Ogra, P. L., Cappola, P. R., MacGillivary, M. G. and Dzierba, J. L., Proc. Soc. Exp. Biol. Med. 145: 811, 1974.PubMedGoogle Scholar
  11. 11.
    Haneberg, B. and Aarskog, D., Clin. Exp. Immunol. 22: 210, 1975.PubMedGoogle Scholar
  12. 12.
    Arnold, R. R., Cole, M. F., Prince, S. and McGhee, J. R., Clin. Immunol. Immunopathol. 8: 475, 1977.PubMedCrossRefGoogle Scholar
  13. 13.
    Schaefer, M. E., Rhodes, M., Prince, S., Michalek, S. M. and McGhee, J. R., J. Dent. Res. 56: 728, 1977.CrossRefGoogle Scholar
  14. 14.
    Mancini, G., Carbornara, A. O. and Heremans, J. F., Immunochemistry 2: 235, 1965.PubMedCrossRefGoogle Scholar
  15. 15.
    Mestecky, J., Kulhavy, R. and Kraus, F. H., J. Immunol. 108: 738, 1972.PubMedGoogle Scholar
  16. 16.
    Osserman, E. F. and Lawlor, D. P., J. Exp. Med. 124: 921, 1966.PubMedCrossRefGoogle Scholar
  17. 17.
    Laurell, C. B., Anal. Biochem. 15: 45, 1966.PubMedCrossRefGoogle Scholar
  18. 18.
    Cole, M. F., Arnold, R. R., Mestecky, J., Prince, S., Kulhavy, R. and McGhee, J. R., in Microbial Aspects of Dental Caries (Edited by Stiles, H. M., Loesche, W. J. and O’Brien, T. C), p. 359, Information Retrieval, Washington, D. C., 1976.Google Scholar
  19. 19.
    Thompson, R. A., Nature 226: 946, 1970.PubMedCrossRefGoogle Scholar
  20. 20.
    Eidelman, S. and Davis, S. D., Lancet 1: 884, 1968.PubMedCrossRefGoogle Scholar
  21. 21.
    Brandtzaeg, P., Clin. Exp. Immunol. 8: 69, 1971.PubMedGoogle Scholar
  22. 22.
    Brandtzaeg, P., Fjellanger, I. and Gjeruldsen, S. T., Science 160: 789, 1968.PubMedCrossRefGoogle Scholar
  23. 23.
    Coelho, I. M., Pereira, M. T., Virella, G. and Thompson, R. A., Clin. Exp. Immunol. 18: 685, 1974.Google Scholar
  24. 24.
    Brandtzaeg, P., Immunology 29: 559, 1975.PubMedGoogle Scholar
  25. 25.
    Hanson, L. A., in Birth Defects, Immunologic Deficiency Diseases in Man (Edited by Bergsma, D.) Vol. IV, No. 1, p. 292, National March of Dimes Foundation, 1968.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Roland R. Arnold
    • 1
    • 2
  • Shirley J. Prince
    • 1
    • 2
  • Jiri Mestecky
    • 1
    • 2
  • Denis Lynch
    • 1
    • 2
  • Monica Lynch
    • 1
    • 2
  • Jerry R. McGhee
    • 1
    • 2
  1. 1.Department of Microbiology and Institute of Dental ResearchUniversity of Alabama in BirminghamBirminghamUSA
  2. 2.Laboratory of Microbiology and Immunology, National Institute of Dental ResearchNational Institutes of HealthBethesdaUSA

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