Salivary IgA Antibodies to Antigens from Streptococcus Mutans in Human Dental Caries

  • S. J. Challacombe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


The tooth surface is exposed to secretory antibodies present in saliva, and to serum antibodies via crevicular fluid. Protection against caries in animals has been achieved by local immunization of rats (1,2) and by systemic immunization of sub-human primates (3–5). In germfree rats protection against caries has been achieved by the induction of salivary antibodies alone (6) whereas in rhesus monkeys protection seems to be associated with serum antibodies (4,5,7).


Antibody Titer Carious Lesion Teichoic Acid Caries Experience Parotid Saliva 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S. J. Challacombe
    • 1
  1. 1.Department of Oral Immunology and MicrobiologyGuy’s Hospital Medical and Dental SchoolsLondonEngland

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