The Effect of Cyclosporin a on Dental Caries in Rats Monoassociated with Actinomyces Viscosus NY 1

  • B. Guggenheim
  • A. Hefti
  • J. J. Burckhardt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Numerous pathomechanisms have been proposed as relevant in periodontal disease (1). The T-cell triggered effector systems have been especially emphasized as the most important mediators of this particular chronic inflammation (2–4). It was therefore tempting to investigate whether T-cell suppression by a suitable antilymphocytic agent had a major influence on the establishment and progression of the disease.


Periodontal Disease Dental Caries Plaque Score Mouse Spleen Cell High Sucrose Diet 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Guggenheim
    • 1
  • A. Hefti
    • 1
  • J. J. Burckhardt
    • 1
  1. 1.Department of Oral Microbiology and General Immunology, Dental InstituteUniversity of ZurichZurichSwitzerland

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